Patents by Inventor Xiaoling Ding

Xiaoling Ding has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240115713
    Abstract: Disclosed are a polyethylene glycol conjugate drug, and a preparation method therefor and the use thereof. Specifically, the present invention relates to a polyethylene glycol conjugate drug represented by formula A or a pharmaceutically acceptable salt thereof, a method for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, an intermediate for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, and the use of the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof in the preparation of a drug.
    Type: Application
    Filed: July 21, 2021
    Publication date: April 11, 2024
    Inventors: Gaoquan LI, Nian LIU, Yongchen PENG, Xiafan ZENG, Gang MEI, Sheng GUAN, Yang GAO, Shuai YANG, Yifeng YIN, Jie LOU, Huiyu CHEN, Kun QIAN, Yusong WEI, Qian ZHANG, Dajun LI, Xiaoling DING, Xiangwei YANG, Liqun HUANG, Xi LIU, Liwei LIU, Zhenwei LI, Kaixiong HU, Hua LIU, Tao TU
  • Patent number: 11813334
    Abstract: The present invention relates to the technical field of medicines, and relates to a polyethylene glycol conjugated drug, a preparation method therefor and the use thereof. In particular, the present invention relates to a polyethylene glycol conjugated drug as shown in formula I or a pharmaceutically acceptable salt thereof. The present invention also relates to a method for preparing the polyethylene glycol conjugated drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugated drug or the pharmaceutically acceptable salt thereof, and the use thereof in the preparation of a drug.
    Type: Grant
    Filed: March 11, 2020
    Date of Patent: November 14, 2023
    Assignee: CHONGQING UPGRA BIOTECHNOLOGY CO., LTD.
    Inventors: Gaoquan Li, Dajun Li, Qian Zhang, Diedie Li, Chengzhi Gao, Yue Liu, Xiaoling Ding, Yusong Wei, Xiangwei Yang, Yongchen Peng, Jia Gao, Qiang Luo, Yanxia Heng, Mei Liu, Yuyang Yi, Xiafan Zeng, Tao Tu, Xiao Tang, Xi Liu, Jianhuan Li, Zhaojie Wang, Bin Wang, Jinping Wan, Mingyang Hou, Jiao Liu, Huiyu Chen, Jie Lou, Yue Yang, Yuanqiang Wang
  • Publication number: 20230348671
    Abstract: A polyethylene glycol conjugate drug synergist, a preparation method therefor, and use thereof, specifically relating to a polyethylene glycol conjugate drug synergist as shown in formula I or a pharmaceutically acceptable salt thereof, a preparation method for the polyethylene glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof, an intermediate for preparing the polyethylent glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof, a composition containing the polyethylene glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof, and use of the polyethylene glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof in preparation of a drug.
    Type: Application
    Filed: July 21, 2021
    Publication date: November 2, 2023
    Inventors: Gaoquan LI, Nian LIU, Xiafan ZENG, Yongchen PENG, Gang MEI, Shuai YANG, Yang GAO, Sheng GUAN, Yifeng YIN, Huiyu CHEN, Jie LOU, Kun QIAN, Xiangwei YANG, Liwei LIU, Zhenwei LI, Kaixiong HU, Hua LIU, Qian ZHANG, Dajun LI, Yusong WEI, Xiaoling DING, Xi LIU, Liqun HUANG, Tao TU
  • Patent number: 11793881
    Abstract: The present invention relates to a polyethylene glycol conjugate medicament, a preparation method therefor and use thereof, and in particular relates to a polyethylene glycol conjugate medicament represented by formula (I) or a pharmaceutically acceptable salt thereof. The present invention also relates to a method for preparing the polyethylene glycol conjugate medicament or a pharmaceutically acceptable salt thereof, and an intermediate of the same, a pharmaceutical composition comprising the polyethylene glycol conjugate medicament or a pharmaceutically acceptable salt thereof, and use thereof in preparing a medicament.
    Type: Grant
    Filed: November 18, 2020
    Date of Patent: October 24, 2023
    Assignee: CHONGQING UPGRA BIOTECHNOLOGY CO., LTD.
    Inventors: Gaoquan Li, Dajun Li, Qian Zhang, Yusong Wei, Yongchen Peng, Xiangwei Yang, Xiafan Zeng, Gang Mei, Diedie Li, Chengzhi Gao, Xiaoling Ding, Yue Liu, Jia Gao, Yuyang Yi, Yanxia Heng, Xi Liu, Tao Tu, Kai Wang, Liwei Liu, Mei Liu, Qiang Luo, Xiao Tang, Jie Lou, Huiyu Chen, Yue Yang, Yuanqiang Wang
  • Publication number: 20230101564
    Abstract: The present invention relates to the technical field of medicines, and relates to a polyethylene glycol conjugated drug, a preparation method therefor and the use thereof. In particular, the present invention relates to a polyethylene glycol conjugated drug as shown in formula I or a pharmaceutically acceptable salt thereof. The present invention also relates to a method for preparing the polyethylene glycol conjugated drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugated drug or the pharmaceutically acceptable salt thereof, and the use thereof in the preparation of a drug.
    Type: Application
    Filed: March 11, 2020
    Publication date: March 30, 2023
    Inventors: Gaoquan LI, Dajun LI, Qian ZHANG, Diedie LI, Chengzhi GAO, Yue LIU, Xiaoling DING, Yusong WEI, Xiangwei YANG, Yongchen PENG, Jia GAO, Qiang LUO, Yanxia HENG, Mei LIU, Yuyang YI, Xiafan ZENG, Tao TU, Xiao TANG, Xi LIU, Jianhuan LI, Zhaojie WANG, Bin WANG, Jinping WAN, Mingyang HOU, Jiao LIU, Huiyu CHEN, Jie LOU, Yue YANG, Yuanqiang WANG
  • Publication number: 20230088403
    Abstract: The present invention relates to a polyethylene glycol conjugate medicament, a preparation method therefor and use thereof, and in particular relates to a polyethylene glycol conjugate medicament represented by formula (I) or a pharmaceutically acceptable salt thereof. The present invention also relates to a method for preparing the polyethylene glycol conjugate medicament or a pharmaceutically acceptable salt thereof, and an intermediate of the same, a pharmaceutical composition comprising the polyethylene glycol conjugate medicament or a pharmaceutically acceptable salt thereof, and use thereof in preparing a medicament.
    Type: Application
    Filed: November 18, 2020
    Publication date: March 23, 2023
    Inventors: Gaoquan LI, Dajun LI, Qian ZHANG, Yusong WEI, Yongchen PENG, Xiangwei YANG, Xiafan ZENG, Gang MEI, Diedie LI, Chengzhi GAO, Xiaoling DING, Yue LIU, Jia GAO, Yuyang Yi, Yanxia HENG, Xi LIU, Tao TU, Kai WANG, Liwei LIU, Mei LIU, Qiang LUO, Xiao TANG, Jie LOU, Huiyu CHEN, Yue YANG, Yuanqiang WANG
  • Publication number: 20230073036
    Abstract: The disclosure relates to the technical field of medicine, specifically to a polyethylene glycol conjugated drug, a preparation method therefor and use thereof, and relates in particular to a polyethylene glycol conjugated drug represented by formula (I) or a pharmaceutically acceptable salt thereof. The disclosure further relates to a method for preparation of the polyethylene glycol conjugated drug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugated drug or a pharmaceutically acceptable salt thereof, and use of the polyethylene glycol conjugated drug or a pharmaceutically acceptable salt thereof in preparation of a medicament.
    Type: Application
    Filed: March 11, 2020
    Publication date: March 9, 2023
    Inventors: Gaoquan LI, Qian ZHANG, Dajun LI, Diedie LI, Chengzhi GAO, Xiaoling DING, Yue LIU, Yusong WEI, Xiangwei YANG, Yongchen PENG, Jia GAO, Qiang LUO, Yanxia HENG, Mei LIU, Yuyang YI, Xiafan ZENG, Tao TU, Xiao TANG, Xi LIU, Jianhuan LI, Zhaojie WANG, Jinping WAN, Mingyang HOU, Jie LOU, Huiyu CHEN, Yue YANG, Yuanqiang WANG
  • Publication number: 20230042006
    Abstract: The present disclosure belongs to the field of livestock molecular biotechnology, and provides kits and methods for pedigree division and paternity testing of domestic pigs. The kits and methods specifically select 14 SSR loci of domestic pigs, especially Anqing six-end-white pigs, and synthesize primers for corresponding loci. Through capillary electrophoresis detection of the ear tissue DNA of 98 Anqing six-end-white pigs, the count of effective alleles, heterozygosity, polymorphism information content, and genetic distance, and exclusion probability at each locus are calculated, the pedigree division of domestic pigs, especially Anqing six-end-white pigs, and paternity testing are conducted. The cumulative exclusion probability of 14 microsatellite loci is 99%.
    Type: Application
    Filed: July 11, 2022
    Publication date: February 9, 2023
    Applicant: ANHUI AGRICULTURAL UNIVERSITY
    Inventors: Yueyun DING, Xiaoling DING, Zongjun YIN, Xudong WU, Xiaodong ZHANG, Xianrui ZHENG, Zijing LING, Qiong CHEN, Yinhui HOU, Chengcheng KONG
  • Publication number: 20220105189
    Abstract: The disclosure relates to the technical field of medicine and in particular to a polyethylene glycol conjugated drug of formula I or a pharmaceutically acceptable salt thereof. The disclosure further relates to a method for preparation and an intermediate of the polyethylene glycol conjugated drug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugated drug or a pharmaceutically acceptable salt thereof, and use of the polyethylene glycol conjugated drug or a pharmaceutically acceptable salt thereof in preparation of a medicament.
    Type: Application
    Filed: June 3, 2019
    Publication date: April 7, 2022
    Inventors: Gaoquan LI, Dajun LI, Qian ZHANG, Xiaoling DING, Diedie LI, Lei HUANG, Jinping WAN, Yue LIU, Yusong WEI, Xiangwei YANG, Yongchen PENG, Jiao LIU, Jianhuan LI, Qiang LUO, Xi LIU, Bin WANG, Hui GONG, Yu CHEN, Yunjie JIANG, Zhongquan LIU, Kun XU, Jie LOU, Huiyu CHEN, Yue YANG, Yuanqiang WANG
  • Publication number: 20180270430
    Abstract: A pixel circuit, a semiconductor camera detection circuit and a display device. The pixel circuit includes: a photodiode, a driving circuit, an initialization circuit, a transmission circuit, a voltage write-in circuit (2 and a compensation circuit. One end of the photodiode is electrically connected to a grounding end, and another end is electrically connected to the transmission circuit; the initialization circuit is configured to pull a voltage of a first node to an initialization voltage under control of the initialization signal end; the transmission circuit is configured to pull down the voltage of the first node from the initialization voltage to a data voltage under control of the first scanning signal end; the voltage write-in circuit is configured to write the data voltage into the driving circuit and output a grounding voltage to the compensation circuit; the compensation circuit is configured to perform threshold voltage compensation on the driving circuit.
    Type: Application
    Filed: April 28, 2017
    Publication date: September 20, 2018
    Inventors: Shengji Yang, Xue Dong, Hailin XUE, Xiaochuan Chen, Haisheng WANG, Lei WANG, Yingming LIU, Xiaoling DING, Ming YANG
  • Patent number: 8501338
    Abstract: A system and method for improving electrochemical power sources through the dispensing encapsulation and dispersion into galvanic chambers of an electrochemical cell. Features of the method include the optimization of the concentration levels of chemicals involved in desired energy producing reactions.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: August 6, 2013
    Assignee: University of South Florida
    Inventors: Andres M. Cardenas-Valencia, Norma A. Alcantar, Xiaoling Ding, Ryan G. Toomey, Lawrence C. Langebrake
  • Patent number: 8163418
    Abstract: A system and method for improving electrochemical power sources through the dispensing, encapsulation and dispersion into galvanic chambers of an electrochemical cell. Features of the method include the optimization of the concentration levels of chemicals involved in desired energy producing reactions.
    Type: Grant
    Filed: November 11, 2008
    Date of Patent: April 24, 2012
    Assignee: University of South Florida
    Inventors: Andres M. Cardenas-Valencia, Norma A. Alcantar, Xiaoling Ding, Ryan G. Toomey, Lawrence C. Langebrake
  • Patent number: 7943259
    Abstract: A system and method for improving electrochemical power sources through the dispensing encapsulation and dispersion into galvanic chambers of an electrochemical cell. Features of the method include the optimization of the concentration levels of chemicals involved in desired energy producing reactions.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: May 17, 2011
    Assignee: University of South Florida
    Inventors: Andres M. Cardenas-Valencia, Norma Alcantar, Xiaoling Ding, Ryan G. Toomey, Larry Langebrake
  • Patent number: 7923072
    Abstract: A method for the formation of regular-shaped silver crystals through a wet chemical reaction (Tollen's reaction) is presented. The growth of the Ag crystals (size, morphology and aggregation) can be controlled via adjusting reaction conditions such as temperature and reducing agent concentrations before and during the reactions. The smaller Ag crystals (50-200 nm) were generated under the condition of limited reductive reagent (glucose), and the larger sliver crystals (˜5 ?m) were the aggregated silver nano-particles (100-200 nm) produced at higher reducing agent concentrations. Most of the larger crystals were in the shape of cube or rectangular cube, and rarely, they were in clusters. The smaller crystals (aggregation of Ag atoms) were shaped in cube or/and cone, and both single crystals and clusters were formed. The presence of impurity (TiO2 nano-particles, 25-50 nm) as crystal seeds enables the 3-D growth of large, irregular-shaped Ag clusters (˜5 ?m).
    Type: Grant
    Filed: January 14, 2005
    Date of Patent: April 12, 2011
    Assignee: University of South Florida
    Inventors: Xiaoling Ding, David Fries
  • Patent number: 7829034
    Abstract: The instant invention provides for a gas purification system in which a reaction chamber combines with catalysts and heating to oxidize and reduce the compounds contained in a gas stream to oxygen and other non-deleterious components. By use of this system closed loop air systems can be effectively supplied with oxygen by chemically converting the volatile organic components to desired gasses and thereby remove unwanted contaminants.
    Type: Grant
    Filed: July 7, 2005
    Date of Patent: November 9, 2010
    Assignee: University of South Florida
    Inventor: Xiaoling Ding
  • Patent number: 7622239
    Abstract: A method for making a patterned SiO2 films over TiO2 (Si02/Ti02) under ambient atmospheric conditions, including room temperature, through photo and chemical reactions. The method is simple, convenient and can be performed in a short period of time, typically less than two hours. The patterned TiO2 film is fabricated through photo-irradiation of a photosensitive organic-titanium film using a mask. Silica particles are generated from silicate solution by adjusting pH values to 10 to 8 with hydrochloric acid. The pre-deposited TiO2 film has a strong attraction for the SiO2 particles, leading to the instant formation of SiO2 film over the TiO2 film. The silica films are also amino-silylated with 3-aminopropyltriethoxysilane toward applications such as patternable, location-specific silica-based separation and purification.
    Type: Grant
    Filed: October 10, 2006
    Date of Patent: November 24, 2009
    Assignee: University of South Florida
    Inventors: Xiaoling Ding, David P. Fries
  • Publication number: 20070184358
    Abstract: A method for making a patterned SiO2 films over TiO2 (SiO2/TiO2) under ambient atmospheric conditions, including room temperature, through photo and chemical reactions. The method is simple, convenient and can be performed in a short period of time, typically less than two hours. The patterned TiO2 film is fabricated through photo-irradiation of a photosensitive organic-titanium film using a mask. Silica particles are generated from silicate solution by adjusting pH values to 10 to 8 with hydrochloric acid. The pre-deposited TiO2 film has a strong attraction for the SiO2 particles, leading to the instant formation of SiO2 film over the TiO2 film. The silica films are also amino-silylated with 3-aminopropyltriethoxysilane toward applications such as patternable, location-specific silica-based separation and purification.
    Type: Application
    Filed: October 10, 2006
    Publication date: August 9, 2007
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Xiaoling Ding, David Fries
  • Publication number: 20070009414
    Abstract: The instant invention provides for a gas purification system in which a reaction chamber combines with catalysts and heating to oxidize and reduce the compounds contained in a gas stream to oxygen and other non-deleterious components. By use of this system closed loop air systems can be effectively supplied with oxygen by chemically converting the volatile organic components to desired gasses and thereby remove unwanted contaminants.
    Type: Application
    Filed: July 7, 2005
    Publication date: January 11, 2007
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventor: Xiaoling Ding
  • Publication number: 20050229747
    Abstract: A method for the formation of regular-shaped silver crystals through a wet chemical reaction (Tollen's reaction) is presented. The growth of the Ag crystals (size, morphology and aggregation) can be controlled via adjusting reaction conditions such as temperature and reducing agent concentrations before and during the reactions. The smaller Ag crystals (50-200 nm) were generated under the condition of limited reductive reagent (glucose), and the larger sliver crystals (˜5 ?m) were the aggregated silver nano-particles (100-200 nm) produced at higher reducing agent concentrations. Most of the larger crystals were in the shape of cube or rectangular cube, and rarely, they were in clusters. The smaller crystals (aggregation of Ag atoms) were shaped in cube or/and cone, and both single crystals and clusters were formed. The presence of impurity (TiO2 nano-particles, 25-50 nm) as crystal seeds enables the 3-D growth of large, irregular-shaped Ag clusters (˜5 ?m).
    Type: Application
    Filed: January 14, 2005
    Publication date: October 20, 2005
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Xiaoling Ding, David Fries