Patents by Inventor Xiaoshan Zhu
Xiaoshan Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10994031Abstract: Disclosed herein are embodiments of composites and compositions that can be used for therapeutic applications in vivo and/or in vitro. The disclosed composites can comprise cores having magnetic nanoparticles, quantum dots, or combinations thereof and zwitterionic polymeric coatings that facilitate solubility and bioconjugation. The compositions disclosed herein can comprise the composites and one or more biomolecules, drugs, or combinations thereof. Also disclosed herein are methods of making the composites, composite components, and methods of making quantum dots for use in the composites.Type: GrantFiled: January 16, 2018Date of Patent: May 4, 2021Assignee: Board of Regents of the Nevada System of Higher Education, on behalf of the University of Nevada, RenoInventors: Xiaoshan Zhu, Violeta Demillo
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Publication number: 20180154024Abstract: Disclosed herein are embodiments of composites and compositions that can be used for therapeutic applications in vivo and/or in vitro. The disclosed composites can comprise cores having magnetic nanoparticles, quantum dots, or combinations thereof and zwitterionic polymeric coatings that facilitate solubility and bioconjugation. The compositions disclosed herein can comprise the composites and one or more biomolecules, drugs, or combinations thereof. Also disclosed herein are methods of making the composites, composite components, and methods of making quantum dots for use in the composites.Type: ApplicationFiled: January 16, 2018Publication date: June 7, 2018Applicant: Board of Regents of the Nevada System of Higher Education, on behalf of the University of Nevada,Inventors: Xiaoshan Zhu, Violeta Demillo
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Patent number: 9482616Abstract: Disclosed herein are methods, kits and systems for signal amplification that can be used for many analytes. For example, a method of detecting an analyte in a sample includes contacting the sample containing the analyte with a detecting agent, wherein the detecting agent contains a specific binding agent that binds the analyte and zinc nanoparticles wherein the zinc nanoparticles and specific binding agent are coupled together; exposing the analyte bound to the specific binding agent which is coupled to the zinc nanoparticles to an acidic condition to release zinc ions from the zinc nanoparticles; contacting the released zinc ions with an indicator to generate a signal; and detecting the signal. The disclosed bioassay can be used in clinical and non-clinical settings. For example, the method can be used for clinical diagnosis, prognosis, and/or treatment-effectiveness or for testing for the presence of a substance like biological or chemical agents.Type: GrantFiled: June 6, 2013Date of Patent: November 1, 2016Assignee: Board of Regents of the Nevada System of Higher Education, on behalf the University of Nevada, RenoInventor: Xiaoshan Zhu
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Publication number: 20130330743Abstract: Disclosed herein are methods, kits and systems for signal amplification that can be used for many analytes. For example, a method of detecting an analyte in a sample includes contacting the sample containing the analyte with a detecting agent, wherein the detecting agent contains a specific binding agent that binds the analyte and zinc nanoparticles wherein the zinc nanoparticles and specific binding agent are coupled together; exposing the analyte bound to the specific binding agent which is coupled to the zinc nanoparticles to an acidic condition to release zinc ions from the zinc nanoparticles; contacting the released zinc ions with an indicator to generate a signal; and detecting the signal. The disclosed bioassay can be used in clinical and non-clinical settings. For example, the method can be used for clinical diagnosis, prognosis, and/or treatment-effectiveness or for testing for the presence of a substance like biological or chemical agents.Type: ApplicationFiled: June 6, 2013Publication date: December 12, 2013Applicant: Board of Regents of the Nevada System of Higher Education, on behalf of the University of NevadaInventor: Xiaoshan Zhu
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Patent number: 6806050Abstract: This invention provides electromagnetic chips and electromagnetic biochips having arrays of individually addressable micro-electromagnetic units, as well as methods of utilizing these chips for directed manipulation of micro-particles and micro-structures such as biomolecules and chemical reagents. An electromagnetic biochip comprises an individually addressable micro-electromagnetic unit chip with ligand molecules immobilized on its surface. By controlling the electromagnetic field at each unit of the array and combining this control with magnetic modification of biomolecules, these chips can be used for directed manipulation, synthesis and release of biomolecules in order to increase sensitivity of biochemical or chemical analysis and reduce assay time. Other advantages with these chips include minimized damages to biological molecules and increased reproducibility of assay results.Type: GrantFiled: September 18, 2001Date of Patent: October 19, 2004Assignee: AVIVA BiosciencesInventors: Yuxiang Zhou, Litian Liu, Ken Chen, Depu Chen, Jia Wang, Zewen Liu, Zhimin Tan, Junquan Xu, Xiaoshan Zhu, Xuezhong He, Wenzhang Xie, Zhiming Li, Xiumel Liu
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Patent number: 6630835Abstract: The present invention concerns a high throughput electrorotation chip having an array of electrorotation units and methods of use thereof. To make the high throughput electrorotation chip, a plurality of electrorotation units (EU) are fabricated on a substrate or support and each EU is capable of producing a rotating electric field upon the application of an appropriate electrical signal. Exemplary embodiments include a row-column configuration of EUs having four electrode elements realized through two conductive-layers. The electrode elements may be linear, concave, or convex. Thin plates having one or multiple holes are bound to high-throughput electrorotation chips to form assay chambers having one or multiple wells. Particles can be introduced to the wells and electrorotation measurements can be performed on the particles.Type: GrantFiled: August 7, 2002Date of Patent: October 7, 2003Assignee: Aviva Biosciences CorporationInventors: Jing Cheng, Junquan Xu, Xiaoshan Zhu, Litian Liu, Xiao-Bo Wang, Lei Wu
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Publication number: 20020190732Abstract: The present invention concerns a high throughput electrorotation chip having an array of electrorotation units and methods of use thereof. To make the high throughput electrorotation chip, a plurality of electrorotation units (EU) are fabricated on a substrate or support and each EU is capable of producing a rotating electric field upon the application of an appropriate electrical signal. Exemplary embodiments include a row-column configuration of EUs having four electrode elements realized through two conductive-layers. The electrode elements may be linear, concave, or convex. Thin plates having one or multiple holes are bound to high-throughput electrorotation chips to form assay chambers having one or multiple wells. Particles can be introduced to the wells and electrorotation measurements can be performed on the particles.Type: ApplicationFiled: August 7, 2002Publication date: December 19, 2002Inventors: Jing Cheng, Junquan Xu, Xiaoshan Zhu, Litian Liu, Xiao-Bo Wang, Lei Wu
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Patent number: 6448794Abstract: The present invention concerns a high throughput electrorotation chip having an array of electrorotation units and methods of use thereof. To make the high throughput electrorotation chip, a plurality of electrorotation units (EU) are fabricated on a substrate or support and each EU is capable of producing a rotating electric field upon the application of an appropriate electrical signal. Exemplary embodiments include a row-column configuration of EUs having four electrode elements realized through two conductive-layers. The electrode elements may be linear, concave, or convex. Thin plates having one or multiple holes are bound to high-throughput electrorotation chips to form assay chambers having one or multiple wells. Particles can be introduced to the wells and electrorotation measurements can be performed on the particles.Type: GrantFiled: August 22, 2000Date of Patent: September 10, 2002Assignee: Aviva Biosciences CorporationInventors: Jing Cheng, Junquan Xu, Xiaoshan Zhu, Litian Liu, Xiao-Bo Wang, Lei Wu
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Patent number: 6355491Abstract: This invention provides electromagnetic chips and electromagnetic biochips having arrays of individually addressable micro-electromagnetic units, as well as methods of utilizing these chips for directed manipulation of micro-particles and micro-structures such as biomolecules and chemical reagents. An electromagnetic biochip comprises an individually addressable micro-electromagnetic unit chip with ligand molecules immobilized on its surface. By controlling the electromagnetic field at each unit of the array and combining this control with magnetic modification of biomolecules, these chips can be used for directed manipulation, synthesis and release of biomolecules in order to increase sensitivity of biochemical or chemical analysis and reduce assay time. Other advantages with these chips include minimized damages to biological molecules and increased reproducibility of assay results.Type: GrantFiled: September 17, 1999Date of Patent: March 12, 2002Assignee: Aviva BiosciencesInventors: Yuxiang Zhou, Litian Liu, Ken Chen, Depu Chen, Jia Wang, Zewen Liu, Zhimin Tan, Junquan Xu, Xiaoshan Zhu, Xuezhong He, Wenzhang Xie, Zhiming Li, Xiumei Liu
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Publication number: 20020022276Abstract: This invention provides electromagnetic chips and electromagnetic biochips having arrays of individually addressable micro-electromagnetic units, as well as methods of utilizing these chips for directed manipulation of micro-particles and micro-structures such as biomolecules and chemical reagents. An electromagnetic biochip comprises an individually addressable micro-electromagnetic unit chip with ligand molecules immobilized on its surface. By controlling the electromagnetic field at each unit of the array and combining this control with magnetic modification of biomolecules, these chips can be used for directed manipulation, synthesis and release of biomolecules in order to increase sensitivity of biochemical or chemical analysis and reduce assay time. Other advantages with these chips include minimized damages to biological molecules and increased reproducibility of assay results.Type: ApplicationFiled: September 18, 2001Publication date: February 21, 2002Inventors: Yuxiang Zhou, Litian Liu, Ken Chen, Depu Chen, Jia Wang, Zewen Liu, Zhimin Tan, Junquan Xu, Xiaoshan Zhu, Xuezhong He, Wenzhang Xie, Zhiming Li, Xiumei Liu