Patents by Inventor Xiaowen GUO
Xiaowen GUO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240107975Abstract: An animal litter, process for preparing the animal litter, and a method for removal of animal waste using the animal litter are provided. The animal litter generally includes at least one sorbent and a sulfate such as sodium bisulfate. The animal litter is in the form of discrete plural particles which tend to agglomerate when wetted.Type: ApplicationFiled: August 30, 2023Publication date: April 4, 2024Inventors: Somayajulu Venkata Satya Gandikota, Rod Hohenadel, Xiaowen Guo
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Publication number: 20230363417Abstract: Disclosed are animal feeding products and methods contemplated to be useful to increase nitric oxide production and mange oxidative stress in an animal. The animal feeding products generally comprise arginine, choline, an ascorbyl compound, and zinc. Also contemplated is a method of feeding an animal comprising administering doses of arginine, choline, an ascorbyl compound, and zinc to a target animal over a period of time. The dose of arginine may range from about 0.2-10% total weight of feed/head/day. The dose of choline may range from about 0.1-10% total weight of feed/head/day. The dose of the ascorbyl compound may range from about 0.015-10% total weight of feed/head/day. The dose of zinc may range from about 0.01-10% total weight of feed/head/day.Type: ApplicationFiled: August 20, 2021Publication date: November 16, 2023Inventors: Xiaowen Guo, Douglas A. Stetzer
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Publication number: 20230174478Abstract: Disclosed is a method for preparing a brivaracetam intermediate shown in formula B-R, comprising: reacting a compound shown in formula B-P and a resolving agent to prepare a compound shown in formula B-Q; and converting the compound shown in formula B-Q into the brivaracetam intermediate shown in formula B-R, wherein the resolving agent is a (1S,2S)-(+)-1,2-diaminocyclohexane compound. Also provided is a method for preparing brivaracetam. According to the method, a mixture of two diastereoisomers of (S)-2-3-propylpyrrolidine-1-yl butyric acid can be conveniently and effectively resolved, and the use of a chiral HPLC column is avoided, thereby greatly shortening the process time, simplifying the operation, reducing the process cost, and facilitating industrial production and enviormental protection.Type: ApplicationFiled: April 30, 2020Publication date: June 8, 2023Inventors: Yipeng ZHAN, Haisheng FAN, Kai YIN, Xiang JI, Boyang LIU, Xiaowen GUO, Luning HUANG, Anping TAO, Jianguo AN, Hong GU
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Publication number: 20230037151Abstract: A method for preparing lurasidone hydrochloride by reacting lurasidone free alkali reacts with hydrochloric acid in a mixed solvent of an alcoholic solvent and an alkyl halide solvent.Type: ApplicationFiled: December 7, 2020Publication date: February 2, 2023Inventors: Yikai ZHANG, Junzheng HUANG, Hao LU, Xiaowen GUO, Yafei JIANG, Yuanhai GAO, Luning HUANG, Anping TAO, Jianguo AN, Hong GU
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Patent number: 11385121Abstract: Provided is a method to acquire the unbalance of a rotor and a balancing machine, in which, the method to acquire the unbalance of a rotor includes the following procedures: install angle sensor at first position on balancing machine, measure the unbalance of rotor, first unbalance in measuring plane 1 and first unbalance in measuring plane 2 can be measured. Move angle sensor on balancing machine from first position to second position, measure the unbalance of the rotor again, second unbalance in measuring plane 1 and second unbalance in measuring plane 2 can be measured. In the above mentioned two measurements, the unbalance amount of rotor has no change, but the unbalance angle relative to angle reference point on rotor is changed by an angle which equals the angle of the sensor being moved.Type: GrantFiled: September 7, 2021Date of Patent: July 12, 2022Inventors: Weijian Guo, Xiaowen Guo
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Patent number: 11365178Abstract: The present invention relates to a method for preparing an intermediate (Formula IV) of sodium elagolix. The intermediate is prepared by the following route. The method has advantages of simple and safe operation, high yield, less environmental pollution, good economic effect and suitability for industrial production, wherein R represents C1-C4 substituted or unsubstituted benzyl or allyl.Type: GrantFiled: December 25, 2018Date of Patent: June 21, 2022Assignees: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD., SHANGHAI SYNCORES TECHNOLOGIES, INCInventors: Hu Su, Xiaowen Guo, Yukun Liang, Kaiqiang Shi, Jintao Yang, Kang He, Anping Tao, Luning Huang, Jianguo An, Xi Chen, Hong Gu
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Publication number: 20220048856Abstract: The present application relates to a method (I) for preparing a brivaracetam intermediate, comprising the steps of dissolving the compound represented by B-P and 1S,2S-diphenylethylenediamine in a solvent for resolution, crystallizing, filtering, and recrystallizing to obtain the compound represented by B-Q, which is then converted to the brivaracetam intermediate represented by B-R. This method can effectively resolve the compound represented by B-P. The present application also provides a method for preparing brivaracetam using the compound represented by B-R. The method can separate the effective components only through simple steps such as extraction, washing, drying, and concentration without requiring use of chiral chromatography column to separate isomers in the preparation process, and thus the separation process is simple, greatly reducing the production cost of brivaracetam.Type: ApplicationFiled: December 12, 2019Publication date: February 17, 2022Inventors: Haisheng FAN, Yipeng ZHAN, Kai YIN, Xiang JI, Fenghao LIU, Kaiqiang SHI, Xiaowen GUO, Luning HUANG, Anping TAO, Jianguo AN, Hong GU
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Publication number: 20210396621Abstract: Provided is a method to acquire the unbalance of a rotor and a balancing machine, in which, the method to acquire the unbalance of a rotor includes the following procedures: install angle sensor at first position on balancing machine, measure the unbalance of rotor, first unbalance in measuring plane 1 and first unbalance in measuring plane 2 can be measured. Move angle sensor on balancing machine from first position to second position, measure the unbalance of the rotor again, second unbalance in measuring plane 1 and second unbalance in measuring plane 2 can be measured. In the above mentioned two measurements, the unbalance amount of rotor has no change, but the unbalance angle relative to angle reference point on rotor is changed by an angle which equals the angle of the sensor being moved.Type: ApplicationFiled: September 7, 2021Publication date: December 23, 2021Inventors: Weijian GUO, Xiaowen GUO
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Publication number: 20200369625Abstract: The present invention relates to a method for preparing an intermediate (Formula IV) of sodium elagolix. The intermediate is prepared by the following route. The method has advantages of simple and safe operation, high yield, less environmental pollution, good economic effect and suitability for industrial production, wherein R represents C1-C4 substituted or unsubstituted benzyl or allyl.Type: ApplicationFiled: December 25, 2018Publication date: November 26, 2020Inventors: Hu Su, Xiaowen Guo, Yukun Liang, Kaiqiang Shi, Jintao Yang, Kang He, Anping Tao, Luning Huang, Jianguo An, Xi Chen, Hong Gu
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Patent number: 10766895Abstract: Disclosed is a preparation method for a Palbociclib free base crystal form A as shown in Formula I, comprising the following steps: treating a Palbociclib free base and/or a Palbociclib salt compound by using an inorganic base in a water solvent at the temperature of 35 to 100?C. to obtain a Palbociclib free base crystal form A, the water solvent being water or mixed solvent obtained by water and an organic solvent capable of being mixed and disclosed in the water. Also disclosed is a preparation method for a Palbociclib free base crystal form B, comprising the following steps: treating a Palbociclib salt compound by using an inorganic base in a water solvent at the temperature of 0 to 20° C. to obtain a Palbociclib free crystal form B, the water solvent being water or a mixed solvent obtained by water and an organic solvent capable of being mixed and dissolved in the water. The method is safe and convenient in operation and low in pollution, and facilitates industrial production.Type: GrantFiled: May 7, 2019Date of Patent: September 8, 2020Assignees: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD., SHANGHAI SYNCORES TECHNOLOGIES INC. LTD.Inventors: Haisheng Fan, Xiaowen Guo, Luning Huang, Hong Gu
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Patent number: 10618891Abstract: The present invention relates to a synthesis process of suvorexant, novel compounds represented by formulas II, III, IV or V, or salts thereof for preparing suvorexant, and a method for preparing the intermediates. The preparation method uses a chiral starting material to synthesize chiral compounds represented by formulas II, III, IV or V, the compounds obtained being used for synthesizing the suvorexant. The preparation method has the advantages of simple operation, low cost, mild reaction conditions, simple post-treatment, easy to purify, high yield, high ee value for the product, and easy to industrialize. In the reaction route shown, R represents benzyl, allyl or 1-phenethyl, or optionally substituted benzyl at the 2 position to 6 position, such as 4-methoxybenzyl, 4-nitrobenzyl, 2-methylbenzyl, 4-chlorobenzyl or 3-fluorobenzyl.Type: GrantFiled: January 25, 2017Date of Patent: April 14, 2020Assignees: Zhejiang Huahai Pharmaceutical Co., Ltd., Shanghai Aobo Pharmtech, Inc., Ltd.Inventors: Jianping Lin, Xiaowen Guo, Xiaofei Gao, Chao Huang, Yuanbing Guo, Anping Tao, Luning Huang, Hong Gu
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Publication number: 20200062720Abstract: A novel preparation method for the anti-gout drug Lesinurad, and a key intermediate thereof. The method comprises the following reaction steps: 1) the compound of formula II undergoing a substitution reaction with R3—SH in the presence of a first solvent and a first alkali to generate a mixture containing the compound of formula III and the compound of formula IV; 2) adding a second alkali and R3X to the resulting mixture for a reaction to obtain the compound of formula III, wherein: R represents a cyclopropane group, a halogen, a triflate group, a mesylate group or a tosylate group, preferably a cyclopropane group; R3 represents —COCH3, a benzyl group or —CH2R4, wherein R4 represents a methyl acetate group, an ethyl acetate group, —C(O)OC2H5, —C(O)OCH3, —CN, —CH2OH or a phenyl group substituted with one or more of a C1-C6 alkyl group and a halogen; X represents a halogen.Type: ApplicationFiled: July 11, 2018Publication date: February 27, 2020Inventors: Qing LI, Fengmin XIA, Chao HUANG, Xiaowen GUO, Anping TAO, Luning HUANG, Hong GU
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Publication number: 20190263809Abstract: Disclosed is a preparation method for a Palbociclib free base crystal form A as shown in Formula I, comprising the following steps: treating a Palbociclib free base and/or a Palbociclib salt compound by using an inorganic base in a water solvent at the temperature of 35 to 100?C. to obtain a Palbociclib free base crystal form A, the water solvent being water or mixed solvent obtained by water and an organic solvent capable of being mixed and disclosed in the water. Also disclosed is a preparation method for a Palbociclib free base crystal form B, comprising the following steps: treating a Palbociclib salt compound by using an inorganic base in a water solvent at the temperature of 0 to 20° C. to obtain a Palbociclib free crystal form B, the water solvent being water or a mixed solvent obtained by water and an organic solvent capable of being mixed and dissolved in the water. The method is safe and convenient in operation and low in pollution, and facilitates industrial production.Type: ApplicationFiled: May 7, 2019Publication date: August 29, 2019Inventors: Haisheng Fan, Xiaowen Guo, Luning Huang, Hong Gu
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Patent number: 10329290Abstract: Disclosed is a preparation method for a Palbociclib free base crystal form A as shown in Formula I, comprising the following steps: treating a Palbociclib free base and/or a Palbociclib salt compound by using an inorganic base in a water solvent at the temperature of 35 to 100° C. to obtain a Palbociclib free base crystal form A, the water solvent being water or mixed solvent obtained by water and an organic solvent capable of being mixed and disclosed in the water. Also disclosed is a preparation method for a Palbociclib free base crystal form B, comprising the following steps: treating a Palbociclib salt compound by using an inorganic base in a water solvent at the temperature of 0 to 20° C. to obtain a Palbociclib free crystal form B, the water solvent being water or a mixed solvent obtained by water and an organic solvent capable of being mixed and dissolved in the water. The method is safe and convenient in operation and low in pollution, and facilitates industrial production.Type: GrantFiled: November 2, 2016Date of Patent: June 25, 2019Assignees: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD, SHANGHAI SYNCORES TECHNOLOGIES INC. LTD.Inventors: Haisheng Fan, Xiaowen Guo, Luning Huang, Hong Gu
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Publication number: 20190040052Abstract: The present invention relates to a synthesis process of suvorexant, novel compounds represented by formulas II, III, IV or V, or salts thereof for preparing suvorexant, and a method for preparing the intermediates. The preparation method uses a chiral starting material to synthesize chiral compounds represented by formulas II, III, IV or V, the compounds obtained being used for synthesizing the suvorexant. The preparation method has the advantages of simple operation, low cost, mild reaction conditions, simple post-treatment, easy to purify, high yield, high ee value for the product, and easy to industrialize. In the reaction route shown, R represents benzyl, allyl or 1-phenethyl, or optionally substituted benzyl at the 2 position to 6 position, such as 4-methoxybenzyl, 4-nitrobenzyl, 2-methylbenzyl, 4-chlorobenzyl or 3-fluorobenzyl.Type: ApplicationFiled: January 25, 2017Publication date: February 7, 2019Inventors: Jianping Lin, Xiaowen Guo, Xiaofei Gao, Chao Huang, Yuanbing Guo, Anping Tao, Luning Huang, Hong Gu
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Publication number: 20180319790Abstract: Disclosed is a preparation method for a Palbociclib free base crystal form A as shown in Formula I, comprising the following steps: treating a Palbociclib free base and/or a Palbociclib salt compound by using an inorganic base in a water solvent at the temperature of 35 to 100° C. to obtain a Palbociclib free base crystal form A, the water solvent being water or mixed solvent obtained by water and an organic solvent capable of being mixed and disclosed in the water. Also disclosed is a preparation method for a Palbociclib free base crystal form B, comprising the following steps: treating a Palbociclib salt compound by using an inorganic base in a water solvent at the temperature of 0 to 20° C. to obtain a Palbociclib free crystal form B, the water solvent being water or a mixed solvent obtained by water and an organic solvent capable of being mixed and dissolved in the water. The method is safe and convenient in operation and low in pollution, and facilitates industrial production.Type: ApplicationFiled: November 2, 2016Publication date: November 8, 2018Inventors: Haisheng Fan, Xiaowen Guo, Luning Huang, Hong Gu
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Patent number: 9951036Abstract: Provide in the present invention is a method for preparing canagliflozin intermediate 2-(2-methyl-5-bromobenzyl)-5-(4-fluorophenyl)thiophene. The method comprises a compound, shown as formula (II), of (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]ketone being reduced under the action of a directly used borane solution or borane locally produced by reacting alkali metal borohydride with a Lewis acid in a suitable solvent and at a suitable temperature, so as to obtain the compound of formula (I) of 2-(2-methyl-5-bromobenzyl)-5-(4-fluorophenyl)thiophene. The preparation method avoids the use of expensive reductive agents and guarantees the complete conversion of raw materials, wherein the post-treatment is simple, the purity of product obtained is high, the reaction yield is high, in the preparation method is simple and convenient, and can easily be used in industry.Type: GrantFiled: June 19, 2015Date of Patent: April 24, 2018Assignees: SHANGHAI SYNCORES TECHNOLOGIES INC. LTD., ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTDInventors: Wenjing Liao, Xiaowen Guo, Luning Huang, Eric Gu
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Publication number: 20170044129Abstract: Provide in the present invention is a method for preparing canagliflozin intermediate 2-(2-methyl-5-bromobenzyl)-5-(4-fluorobenzene)thiophene. The method comprises a compound, shown as formula (II), of (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]ketone being reduced under the action of a directly used borane solution or borane locally produced by reacting alkali metal borohydride with a Lewis acid in a suitable solvent and at a suitable temperature, so as to obtain the compound of formula (I) of 2-(2-methyl-5-bromobenzyl)-5-(4-fluorobenzene)thiophene. The preparation method avoids the use of expensive reductive agents and guarantees the complete conversion of raw materials, wherein the post-treatment is simple, the purity of product obtained is high, the reaction yield is high, in the preparation method is simple and convenient, and can easily be used in industry.Type: ApplicationFiled: June 19, 2015Publication date: February 16, 2017Applicants: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD., SHANGHAI SYNCORES TECHNOLOGIES INC. LTD., SHANGHAI SYNCORES TECHNOLOGIES INC. LTD.Inventors: Wenjing Liao, Xiaowen Guo, Luning Huang, Eric Gu
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Publication number: 20150299153Abstract: The disclosure claims a continuous processing method of 2-Methyltetrahydrofuran (2-MeTHF), including the steps as follows: introducing gasification furfural and hydrogen into a first reaction zone and processing a first catalytic hydrogenation reaction; introducing the gas which is output from the first reaction zone to a second reaction zone to implement a secondary catalytic hydrogenation reaction; and condensing the gas output from the second reaction zone to obtain the 2-MeTHF; wherein, the first reaction zone is filled with a catalyst which is used for aldehyde group reduction, and the second reaction zone is filled with the catalyst for aromatic saturation hydrogenation. By adopting the low-toxicity catalyst which is cheap and easy to get, the high-purity 2-MeTHF can be produced by implementing the gas-phase continuous reaction by the furfural under low pressure or ambient pressure, the traditional process which has high pressure, high investment and high risk can be changed.Type: ApplicationFiled: October 25, 2012Publication date: October 22, 2015Inventors: Hao HONG, Pingzhong HUANG, Jiangping LU, Xin ZHANG, Xiaowen GUO, Xingfang SUN, Jian TAO