Abstract: siRNA molecules targeting AGT mRNA that reduce or inhibit AGT production are provided. Pharmaceutical compositions containing such siRNA molecules also are provided, together with methods of their use for treating hypertension. Pharmaceutical compositions containing at least one oligonucleotide covalently linked to, and delivered to a target cell by, a peptide docking vehicle (PDoV) are capable of reducing or inhibiting the production of AGT and treating hypertension. The PDoV may contain a targeting ligand such as a GalNAc moiety conjugated to the PDoV which targets the complex to hepatocytes.

Abstract: Pharmaceutical constructs containing a Peptide Docking Vehicle (PDoV) covalently linked to: (a) a targeting moiety; and (b) a first therapeutic nucleic acid, are provided, where the therapeutic nucleic acid inhibits replication of Hepatitis B virus (HBV). Methods of using the constructs for treating HBV in subjects also are provided.

Abstract: Disclosed herein are acyclic sulfated cucurbit[n]uril containing sulfate substituent(s), compositions containing the same, and method of preparation thereof. These compounds are useful, for example, as sequestering agents for drugs of abuse.

Abstract: siRNA compositions are provided that contain gemcitabine (GEM) in place of cytosine moieties within the siRNA sequence. Pharmaceuticals compositions containing these siRNA molecules, and methods of using the compositions for treating diseases such as cancer are provided.

Abstract: A local management-based Power Over Ethernet (PoE) switch and a management system. The PoE switch includes a casing, a Liquid Crystal Display (LCD) screen, a monitoring Micro Control Unit (MCU) module, a power system module, a display module, a PoE system module, a switch system module, a key group arranged on the casing, and a key module. The key module transmits information to the MCU module through the display module, and the MCU module connected with the display module, the PoE system module, the switch system module and the key module respectively through a bus performs corresponding operation according to the information. By adoption of the technical solution, working states of the PoE and switch system modules are visually displayed on the screen, and then are correspondingly processed according to the information and displayed on the screen.

Abstract: A novel nucleic acid delivery system is provided containing a linear histidine-lysine rich cysteine-containing peptide bearing a targeting function, and a four branched histidine-lysine rich polypeptide. The delivery system includes a nucleic acid, such as an siRNA. The components form a nanoparticle complex through multiple non-covalent interactions between the phosphates of siRNA and histidine/lysine of the polypeptide, with reduced toxicity. The stable complex selectively delivers the genetic material to cells. The targeting function enhances the efficiency of the nucleic acid delivery and transfection. Carrier molecules also are provided that have the ability to deliver a therapeutic molecule to a specific cell within a tissue in the body. The carrier molecule is modified with a targeting ligand capable of binding to specific receptors present or upregulated on the cell to be targeted. The therapeutic molecule is an siRNA, miRNA, or other oligonucleotide.

Abstract: A POE switch includes a switch module, a POE power supply module and a standard selection module. The microcontroller is communicatively connected with the POE power supply module, the selection unit is connected with the microcontroller and configured to receive an external operation and output an operation signal to the microcontroller, and the microcontroller is configured to control the POE power supply module to supply power to the PD with a corresponding power supply standard according to the operation signal. By operating the selection unit, the microcontroller can control the POE power supply module to supply power to the PD with a corresponding power supply standard. One PSE can supply power to all types of PDs, therefore the compatibility of the POE switch is improved, and the flexibility of building a POE system is improved accordingly.

Abstract: The invention relates to the targeted delivery of therapeutic molecules to organs, tissues, and cells of humans and other mammals. The invention is directed to a chemical construct for delivering such therapeutic molecules and to methods of making and using the constructs.

Abstract: Methods and system are provided for locking a half shaft to a wheel hub to engage four wheel drive are disclosed. In one example, a wheel hub is locked to a half shaft via a radially expanding engagement mechanism. The radially expanding engagement mechanism is without grease and without springs.

Abstract: Peptide docking vehicle compositions containing a therapeutic compound, such as an siRNA molecule, and a targeting ligand are provided, together with methods for their preparation and use. The compositions and methods allow targeted cell/tissue delivery of the therapeutic compound to a subject by linking a targeting ligand to the compound to provide enhanced therapeutic benefit. The subject may be an animal or a human.

Abstract: The present invention provides certain peptides and polypeptides useful in the preparation of nanoparticles for delivering nucleic acids and pharmaceutical drugs to mammalian cells and to humans and other mammals. It further provides methods for making the peptides, polypeptides, and nanoparticles and methods for using the nanoparticles.

Abstract: Methods and system are provided for locking a half shaft to a wheel hub to engage four wheel drive are disclosed. In one example, a wheel hub is locked to a half shaft via a radially expanding engagement mechanism. The radially expanding engagement mechanism is without grease and without springs.

Abstract: A local management-based Power Over Ethernet (PoE) switch and a management system. The PoE switch includes a casing, a Liquid Crystal Display (LCD) screen, a monitoring Micro Control Unit (MCU) module, a power system module, a display module, a PoE system module, a switch system module, a key group arranged on the casing, and a key module. The key module transmits information to the MCU module through the display module, and the MCU module connected with the display module, the PoE system module, the switch system module and the key module respectively through a bus performs corresponding operation according to the information. By adoption of the technical solution, working states of the PoE and switch system modules are visually displayed on the screen, and then are correspondingly processed according to the information and displayed on the screen.

Abstract: Methods and systems are provided for starting a vehicle engine. In one example, an engine starter system for starting the vehicle engine may comprise a ring gear coupled to an engine crankshaft, and a pinion gear coupled to a starter motor, the pinion gear having rotatable rocker elements for engaging the ring gear. In this way, the pinion gear may be engaged with the ring gear to transmit torque from the starter motor to the engine crankshaft to quickly start the engine.

Abstract: Embodiments of the present invention provide a method of processing a surface of a polysilicon and a method of processing a surface of a substrate assembly. The method of processing a surface of a polysilicon includes forming a material film on the surface of the polysilicon; and processing, by using a chemico-mechanical polishing technology, the surface of the polysilicon on which the material film is formed. The material film is selected such that the polysilicon is preferentially removed in a polishing process.

Abstract: A manufacturing method for a polysilicon thin film is provided. The manufacturing method for a polysilicon thin film includes forming a polysilicon layer, treating a surface of the polysilicon layer so that the surface of the polysilicon layer is electronegative, and supplying polar gas into a process chamber so that polar molecules of the polar gas are adsorbed on the surface of the polysilicon layer which is electronegative so as to form the polysilicon thin film, a surface of which has a hole density higher than an electron density.

Abstract: The embodiments of the present disclosure provide a polysilicon thin film transistor and manufacturing method thereof, an array substrate, and a display panel. The method for manufacturing a polysilicon thin film transistor comprises: forming, on a substrate, a gate, a source and a drain, and an active layer. Forming the active layer comprises: forming a polysilicon layer on the substrate, which comprises a channel region and extension regions; performing ion injection process in the extension regions to form lightly-doped regions close to the channel region and a source region and a drain region; prior to or following the formation of the lightly-doped regions, employing halo ion injection process to form halo regions at the positions of the channel region which are close to the lightly-doped regions.

Abstract: The embodiments of the present invention disclose a low temperature poly-silicon (LTPS) transistor array substrate and a method of fabricating the same, and a display device. The LTPS transistor array substrate comprises a substrate; a poly-silicon semiconductor active region provided on the substrate; a gate insulated from the poly-silicon semiconductor active region; and a dielectric spacer region provided on a side wall of the gate, wherein a portion of the poly-silicon semiconductor active region corresponding to the dielectric spacer region comprises a buffer region, and the dielectric spacer region surrounds the side wall of the gate and covers the buffer region.

Abstract: A decoder resource allocating method includes: recording a total resource occupied percentage of each decoder occupied by video which are playing; acquiring a decoder selecting method, a decoding type, and a required decoder resource of a current path video; and looking up a decoder performance parameter table according to the total resource occupied percentage of each decoder, the decoder selecting method, the decoding type, and the required decoder resource to select a suitable decoder resource. A corresponding decoder resource allocating apparatus is also provided. The present invention can flexibly select a decoder according to the play requirement and the available resource of the decoders to secure the success rate of playing and implement multi-path play for signal decoder to elevate the resource utilizing rate of the decoder and lower the manufacturing cost.

Abstract: A manufacturing method for a polysilicon thin film is provided. The manufacturing method for a polysilicon thin film includes forming a polysilicon layer, treating a surface of the polysilicon layer so that the surface of the polysilicon layer is electronegative, and supplying polar gas into a process chamber so that polar molecules of the polar gas are adsorbed on the surface of the polysilicon layer which is electronegative so as to form the polysilicon thin film, a surface of which has a hole density higher than an electron density.