Abstract: The present disclosure relates to the fields of nuclear medicine and molecular imaging, and specifically relates to a dual-targeting compound and a preparation method and application thereof. The dual-targeting compound has the following structure shown in Formula (I). The present disclosure also provides a dual-targeting compound capable of being labeled with a radionuclide, and the compound has the following structure shown in Formula (I-1) or Formula (1-2). The dual-targeting compound of the present disclosure has high affinity for an FAP target and an integrin ?v?3 target, can realize synergistic targeting of the FAP target and the integrin ?v?3 target in tumors, and has high uptake in tumors and long retention time in tumors.

Abstract: The present disclosure provides a truncated Evans Blue modified fibroblast activation protein inhibitor compound. The compound is formed by connecting truncated Evans Blue, a fibroblast activation protein inhibitor and a nuclide chelating group by means of connecting groups L1, L2, L3, L4 and X. The compound has the following structure shown in Formula (I), where R1 is a fibroblast activation protein inhibitor; L1 is lysine, glutamic acid, or a derivative structure thereof; L2 is —(CH2)n—, n is an integer from 0 to 30, and each —CH2— may be individually substituted or unsubstituted with —O—, —NH—, —(CO)—, —NH(CO)—, or —(CO)—NH—; L3 is —(CH2)m—, m is an integer from 0 to 30, and each —CH2— may be individually substituted or unsubstituted with —O— or —(CO)—; L4 is —(CH2)p—, p is an integer from 0 to 30, and each —CH2— may be individually substituted or unsubstituted with —O—, —NH—, —(CO)—, —NH(CO)—, or —(CO)—NH—; X is selected from N, C, O, S, or and R2 is a nuclide chelating group.

Abstract: The present disclosure relates to the fields of nuclear medicine and molecular imaging, and specifically relates to a dual-targeting compound and a preparation method and application thereof. The dual-targeting compound has the following structure shown in Formula (I). The present disclosure also provides a dual-targeting compound capable of being labeled with a radionuclide, and the compound has the following structure shown in Formula (I-1) or Formula (I-2). The dual-targeting compound of the present disclosure has high affinity for an FAP target and an integrin ?v?3 target, can realize synergistic targeting of the FAP target and the integrin ?v?3 target in tumors, and has high uptake in tumors and long retention time in tumors.

Abstract: The present disclosure provides a compound targeting prostate specific membrane antigen (PSMA), wherein the compound has the following structure shown in Formula (I); R1 is a compound structure targeting prostate specific membrane antigen; L1 is -(X)n-(CH2)m-(Y)q-, X and Y are independently selected from lysine, glutamic acid or a derivative structure containing lysine and glutamic acid, n is an integer from 0 to 12, m is an integer from 0 to 60, q is an integer from 0 to 12, and each CH2 may be individually substituted with —O—, —NH(CO)—, or —(CO)—NH—; L2 is -(CH2)p-, p is an integer from 0 to 30, and each CH2 may be individually substituted with —O—, —NH(CO)—, or —(CO)—NH—; and R2 is a nuclide chelating group. The present disclosure also provides a radiolabeled complex based on the structure of the compound.

Abstract: The disclosed computer-implemented method may include dynamically selecting transportation options to present to a transportation requestor device based on current transportation network conditions and transportation requestor device history. In some embodiments, transportation network may have many different ways of arranging a transportation requestor's trip, such as private rides, shared rides, immediate rides, and delayed rides. In some examples, the requestor's choice of transportation option may have an impact on the transportation network. In anticipation of or in response to a transportation request, the method may determine which transportation options will better benefit the transportation network and determine which transportation options to display to the requestor and/or the prominence with which the transportation products are displayed. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The present disclosure provides a compound targeting prostate specific membrane antigen (PSMA), wherein the compound has the following structure shown in Formula (I); R1 is a compound structure targeting prostate specific membrane antigen; L1 is —(X)n—(CH2)m—(Y)q—, X and Y are independently selected from lysine, glutamic acid or a derivative structure containing lysine and glutamic acid, n is an integer from 0 to 12, m is an integer from 0 to 60, q is an integer from 0 to 12, and each CH2 may be individually substituted with —O—, —NH(CO)—, or —(CO)—NH—; L2 is —(CH2)p—, p is an integer from 0 to 30, and each CH2 may be individually substituted with —O—, —NH(CO)—, or —(CO)—NH—; and R2 is a nuclide chelating group. The present disclosure also provides a radiolabeled complex based on the structure of the compound.

Abstract: The disclosed computer-implemented method may include dynamically selecting transportation options to present to a transportation requestor device based on current transportation network conditions and transportation requestor device history. In some embodiments, transportation network may have many different ways of arranging a transportation requestor's trip, such as private rides, shared rides, immediate rides, and delayed rides. In some examples, the requestor's choice of transportation option may have an impact on the transportation network. In anticipation of or in response to a transportation request, the method may determine which transportation options will better benefit the transportation network and determine which transportation options to display to the requestor and/or the prominence with which the transportation products are displayed. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A sealing vibrational-counterrotation-proof hose joint capable of solving the poor sealing performance and the poor vibrational-counterrotation-proof performance of the prior hose joints, comprising a joint main body and a screw cap; a connecting section is arranged on the joint main body, and the screw cap is connected to the connecting section; the connecting section is provided with hooking claws; a squeezing section is arranged on the screw cap, and the squeezing section can squeeze the hooking claws, thereby enabling the hooking claws to bend towards the central axis of the joint main body; the screw cap is provided with locking blocks; the side wall of the connecting section is provided with locking grooves and a plurality of spiral guide bars; the spiral guide bars are uniformly distributed in a circumferential direction by taking the central axis of the joint main body as the center.

Abstract: The disclosed computer-implemented method may include dynamically selecting transportation options to present to a transportation requestor device based on current transportation network conditions and transportation requestor device history. In some embodiments, transportation network may have many different ways of arranging a transportation requestor's trip, such as private rides, shared rides, immediate rides, and delayed rides. In some examples, the requestor's choice of transportation option may have an impact on the transportation network. In anticipation of or in response to a transportation request, the method may determine which transportation options will better benefit the transportation network and determine which transportation options to display to the requestor and/or the prominence with which the transportation products are displayed. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Disclosed in the present disclosure is an electromagnetic compatibility type cable locking joint. The electromagnetic compatibility type cable locking joint comprises a joint main body, a joint cap, a sealing ring, and a shielding member. The joint main body has a central hole, and an inner step is provided in the central hole. The sealing ring is connected to the end of the joint main body, and a positioning groove is formed between the sealing ring and the inner step. The joint cap is connected to the sealing ring, the shielding member comprises an upper ring, a lower ring, and an arc-shaped elastic piece. A plurality of arc-shaped elastic pieces are uniformly arranged in a circle. The upper end of each arc-shaped elastic piece is formed on the upper ring, and the lower end of each arc-shaped elastic piece is formed on the lower ring.

Abstract: A sealing vibrational-counterrotation-proof hose joint capable of solving the poor sealing performance and the poor vibrational-counterrotation-proof performance of the prior hose joints, comprising a joint main body and a screw cap; a connecting section is arranged on the joint main body, and the screw cap is connected to the connecting section; the connecting section is provided with hooking claws; a squeezing section is arranged on the screw cap, and the squeezing section can squeeze the hooking claws, thereby enabling the hooking claws to bend towards the central axis of the joint main body; the screw cap is provided with locking blocks; the side wall of the connecting section is provided with locking grooves and a plurality of spiral guide bars; the spiral guide bars are uniformly distributed in a circumferential direction by taking the central axis of the joint main body as the center.

Abstract: Disclosed in the present disclosure is an electromagnetic compatibility type cable locking joint. The electromagnetic compatibility type cable locking joint comprises a joint main body, a joint cap, a sealing ring, and a shielding member. The joint main body has a central hole, and an inner step is provided in the central hole. The sealing ring is connected to the end of the joint main body, and a positioning groove is formed between the sealing ring and the inner step. The joint cap is connected to the sealing ring, the shielding member comprises an upper ring, a lower ring, and an arc-shaped elastic piece. A plurality of arc-shaped elastic pieces are uniformly arranged in a circle. The upper end of each arc-shaped elastic piece is formed on the upper ring, and the lower end of each arc-shaped elastic piece is formed on the lower ring.

Abstract: The disclosed computer-implemented method may include dynamically selecting transportation options to present to a transportation requestor device based on current transportation network conditions and transportation requestor device history. In some embodiments, transportation network may have many different ways of arranging a transportation requestor's trip, such as private rides, shared rides, immediate rides, and delayed rides. In some examples, the requestor's choice of transportation option may have an impact on the transportation network. In anticipation of or in response to a transportation request, the method may determine which transportation options will better benefit the transportation network and determine which transportation options to display to the requestor and/or the prominence with which the transportation products are displayed. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The present invention claims a TR069 protocol management method oriented to a WIA-PA network, where a traditional TR069 network management system architecture is improved to extend a TR069 protocol only oriented to Internet terminal device management in an initial design from the Internet to a WIA-PA wireless sensor network; a session connection interaction process between an ACS and a CPE is expanded to establish a session connection between the ACS and a WIA-PA network node; a virtual device mechanism is designed by taking a WIA-PA network gateway as the CPE to store a TR069 data model and proxy device information corresponding to a WIA-PA data model and implement the TR069 protocol to manage the WIA-PA network node in a manner as simple and transparent as that for an interaction between the ACS and the common CPE; a management data model mapping mechanism is designed to establish a correlation from the WIA-PA data model described in TR069 to a standard WIA-PA data model; and a protocol conversion interlace

Abstract: The present invention claims a TR069 protocol management method oriented to a WIA-PA network, where a traditional TR069 network management system architecture is improved to extend a TR069 protocol only oriented to Internet terminal device management in an initial design from the Internet to a WIA-PA wireless sensor network; a session connection interaction process between an ACS and a CPE is expanded to establish a session connection between the ACS and a WIA-PA network node; a virtual device mechanism is designed by taking a WIA-PA network gateway as the CPE to store a TR069 data model and proxy device information corresponding to a WIA-PA data model and implement the TR069 protocol to manage the WIA-PA network node in a manner as simple and transparent as that for an interaction between the ACS and the common CPE; a management data model mapping mechanism is designed to establish a correlation from the WIA-PA data model described in TR069 to a standard WIA-PA data model; and a protocol conversion interlace

Abstract: A CMOS amplifier with integrated tunable band-pass function, a tunable active resistor structure, a method of amplifying an input signal and a method of fabricating an amplifier. The tunable active resistor structure comprises two symmetrically cross-coupled transistors.

Abstract: A CMOS amplifier with integrated tunable band-pass function, a tunable active resistor structure, a method of amplifying an input signal and a method of fabricating an amplifier. The tunable active resistor structure comprises two symmetrically cross-coupled transistors.