Abstract: A compound, as represented by formula I, as a TLR7 agonist, a method for preparing the compound, and the use of the compound in treating diseases mediated by the TLR7 agonist are provided. Studies on the activity of a human-derived receptor, a TLR7 agonist, show that compounds have a strong agonistic effect on the human-derived receptor, TLR7, and can be used as a foreground compound for treating diseases mediated by the TLR7 agonist.

Abstract: Embodiments of the disclosed technologies receive a first signal from a user session and create a first ranked list of content items. Based on the first signal, a first subset of the first ranked list is assigned to a first set of slots of the user session. A second subset of the first ranked list is assigned to a second set of slots of the user session. Based on user activity data and position context data, a second ranked list of content items is created. The second ranked list is assigned instead of the second subset to the second plurality of slots.

Abstract: Application of glutamate dehydrogenase GdhA of Peptostreptococcus asaccharolyticus in increasing the yield of poly-?-glutamic acid from Bacillus licheniformis. The glutamate dehydrogenase GdhA of the Bacillus licheniformis WX-02 per se is replaced with the glutamate dehydrogenase derived from the Peptostreptococcus asaccharolyticus by means of homologous recombination, which significantly increases the level of synthesizing the poly-?-glutamic acid for the Bacillus licheniformis, and the yield of the obtained poly-?-glutamic acid from strains is increased at least by more than 20% compared with control strains.

Abstract: A method is described of preparing a curable conductive polyorganosiloxane composition especially having high content of conductive filler and a curable conductive polyorganosiloxane composition preferably obtained therefrom and a premixed conductive paste. A cured conductive silicone rubber obtained by such curable conductive polyorganosiloxane composition is also described as well as the use thereof, especially in electromagnetic shielding. Also described, are electrical wires and cables including such cured conductive silicone rubber. A higher content of conductive fillers can be loaded while enabling good processability by initially preparing a premixed conductive paste including an organopolysiloxane with specific dynamic viscosity and at least a portion of the conductive fillers, and then mixing the premixed conductive paste with the organopolysiloxane masterbatch including at least one organopolysiloxane A and optionally at least one reinforcing filler to obtain a mixture.

Abstract: The present disclosure relates to a method and system for evaluating the macro resilience of offshore oil well control equipment. The method for evaluating the macro resilience of offshore oil well control equipment comprises six steps: determining the type and strength of external disaster; calculating the failure rate of components; calculating the recovery rate of the components; modeling the BN for a degradation process; modeling the BN for a maintenance process; and calculating the resilience of the offshore oil well control equipment. A system for evaluating the macro resilience of offshore oil well control equipment comprises an external disaster evaluation module, a component failure rate calculation subsystem, a reliability degradation process simulation module, a fault identification module, a component recovery rate calculation module, a reliability recovery process simulation module, a reliability change curve derivation unit and an resilience calculation unit.

Abstract: A human-computer interaction method and apparatus. Said method may include: receiving information of at least one modality of a user (201); identifying, on the basis of the information of the at least one modality, intention information of the user and user emotional features corresponding to the intention information (202); determining, on the basis of the intention information, reply information to the user (203); selecting, on the basis of the user emotional features, character emotional features to be fed back to the user (204); and generating, on the basis of the character emotional features and the reply information, a broadcast video of an animated character corresponding to the character emotional features (205).

Abstract: A direct tensile and acoustic testing machine under rock seepage includes a sample and a support frame. A top of the support frame is fixed with a top plate, a bearing plate is provided above the top plate, the bearing plate is provided with a plurality of vertical force transferring rods, the force transferring rods vertically penetrate through the top plate and sliding fit with the top plate, lower ends of the force transferring rods are provided with a tensile base, a top of the tensile base is provided with a lower clamp holder, a bottom of the top plate is provided with an upper clamp holder, and a clamp center of the upper clamp holder overlaps with a clamp center of the lower clamp holder. An acoustic component and a seepage component are provided in the upper clamp holder and the lower clamp holder.

Abstract: A fluorescent compound for acid detection is strongly emissive in the solid state and can aggregate in the presence of an acid. As such, a fluorescent intensity emitted from the compound can be enhanced from an original intensity level in the presence of an acid. The fluorescent compound can emit an enhanced fluorescent intensity in the presence of an ultra-low acid concentration, for example, a concentration of at least about 10?20 M.

Abstract: A data partition storage system is provided. The system includes: a data analysis device, configured to determine, according to a data feature of target data comprised in a database, a heat level corresponding to the target data; and a database kernel, deployed on a target device different from the data analysis device to form the database, and configured to: acquire the heat level corresponding to the target data transmitted by the data analysis device; and store the target data in a storage area corresponding to the heat level.

Abstract: A method of fabricating an optical lens disclosed herein includes forming a layer of a flat lens structure on a front surface of a substrate, depositing a protective metal layer on the layer of the flat lens structure and on a back surface of the substrate, wherein the protective layer includes chromium, gold, titanium, or nickel, wherein the back surface is located opposite to and away from the front surface having the layer of the flat lens structure, irradiating the protective metal layer at the front surface with a laser to form a channel (i) through the protective metal layer, (ii) through the layer of the flat lens structure and (iii) in the substrate, removing the protective metal layer at the front surface and the back surface of the substrate, and separating the layer of the flat lens structure from the substrate to obtain the optical lens, wherein the channel has a depth defined by a thickness of the substrate remaining at the channel after irradiating the protective metal layer at the front surface

Abstract: Embodiments of this application provide a data transmission method, apparatus, and device. The method includes: A first apparatus obtains a first link quality packet message, where the first link quality packet message includes link quality information and indication information, and the indication information is used to indicate that the link quality information is buffered; and the first apparatus sends the first link quality packet message to a second apparatus, where the first link quality packet message is used by the second apparatus to perform network optimization based on the first link quality packet message. This improves accuracy of network optimization.

Abstract: Systems and methods of reconstructing photoacoustic imaging data corresponding to a brain of a subject through a skull of a subject utilizing a reconstruction method that incorporates a spatial model of one or more acoustic properties of the brain and skull of the subject derived from an adjunct imaging dataset.

Abstract: Systems and methods of reconstructing photoacoustic imaging data corresponding to a brain of a subject through a skull of a subject utilizing a reconstruction method that incorporates a spatial model of one or more acoustic properties of the brain and skull of the subject derived from an adjunct imaging dataset.