Patents by Inventor Xin-Min Wang
Xin-Min Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9175406Abstract: There is provided a metallic glass component with its surface layer having both durability of a film and chromatic color properties, and a method for forming the surface layer. Surface active treatment is performed wherein the surface of the metallic glass component is reacted with a mixed aqueous solution of nitric acid and hydrofluoric acid to remove an oxide film and to provide an anchor bond shape on the surface of a metallic glass component, and electroplating or electroless plating is then performed, to form a plating film on the surface of the metallic glass component. It is thereby possible to form a surface layer of a metallic glass which has both durability and a chromatic color.Type: GrantFiled: March 13, 2007Date of Patent: November 3, 2015Assignees: TOKOKU UNIVERSITY, NGK INSULATORS, LTD.Inventors: Xin Min Wang, Naokuni Muramatsu, Junsuke Kiuchi, Hiroshi Suzuki, Tatsue Arakawa, Hisamichi Kimura, Akihisa Inoue, Eiichi Makabe
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Patent number: 7976848Abstract: Synthetic DNA molecules encoding the HPV58 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV58 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV58 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV58 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and are also useful for treatment of existing HPV infections.Type: GrantFiled: January 26, 2009Date of Patent: July 12, 2011Assignee: Merck Sharp & Dohme Corp.Inventors: Janine T. Bryan, Michelle K. Brownlow, Loren D. Schultz, Xin-Min Wang, Kathrin U. Jansen
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Publication number: 20100272749Abstract: Synthetic DNA molecules encoding the HPV58 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV58 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV58 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV58 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and are also useful for treatment of existing HPV infections.Type: ApplicationFiled: January 26, 2009Publication date: October 28, 2010Inventors: Janine T. Bryan, Michelle K. Brownlow, Loren D. Schultz, Xin-Min Wang, Kathrin U. Jansen
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Publication number: 20100203496Abstract: The present invention relates a fluorescent multiplex PCR assay for detecting the presence of a nucleic acid sequence of an HPV type in a sample using multiple fluorophores to simultaneously detect a plurality of HPV genes of the same HPV type, wherein the HPV type is selected from the group consisting of: HPV31, HPV45, HPV52, and HPV58. The present invention also relates to oligonucleotide primers and probes specific to said HPV types for use in the methods of the present invention.Type: ApplicationFiled: April 24, 2006Publication date: August 12, 2010Inventors: Frank J. Taddeo, Deemarie Skulsky, Xin-Min Wang, Kathrin U. Jansen
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Publication number: 20100089761Abstract: There is provided a metallic glass component with its surface layer having both durability of a film and chromatic color properties, and a method for forming the surface layer. Surface active treatment is performed wherein the surface of the metallic glass component is reacted with a mixed aqueous solution of nitric acid and hydrofluoric acid to remove an oxide film and to provide an anchor bond shape on the surface of a metallic glass component, and electroplating or electroless plating is then performed, to form a plating film on the surface of the metallic glass component. It is thereby possible to form a surface layer of a metallic glass which has both durability and a chromatic color.Type: ApplicationFiled: March 13, 2007Publication date: April 15, 2010Applicants: TOHOKU UNIVERSITY, EYETEC CO., LTD., NGK INSULATORS, LTD., MAKABE R&D CO., LTD.Inventors: Xin Min Wang, Naokuni Muramatsu, Junsuke Kiuchi, Hiroshi Suzuki, Tatsue Arakawa, Hisamichi Kimura, Akihisa Inoue, Eiichi Makabe
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Publication number: 20100073624Abstract: Disclosed are: a structural member for use in an eyeglass which has a super elastic property and shape memory property while retaining an excellent biocompatibility in addition to the fact that it is N-free, and which also has an excellent cold workability; an eyeglass frame comprising the structural member; and a process for producing the structural member or eyeglass frame. A structural member for an eyeglass comprising a Ti—Nb—Zr alloy which comprises (A) 40 to 75% by weight of Ti, (B) 18 to 30% by weight of Nb, (C) 10 to 30% by weight of Zr and (D) 0.2 to 3.7% by weight of at least one additive metal element selected from the group consisting of Al, In and Ga.Type: ApplicationFiled: June 12, 2006Publication date: March 25, 2010Inventors: Xin Min WANG, Hiroyuki TADA
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Publication number: 20100003665Abstract: The present invention relates a fluorescent multiplex PCR assay for detecting the presence of an HPV type in a sample using multiple fluorophores to simultaneously detect a plurality of HPV genes of the same HPV type, wherein the HPV type is selected from the group consisting of: HPV33, HPV35, HPV39, HPV51, HPV56, and HPV59. The present invention also relates to oligonucleotide primers and probes specific to said HPV types for use in the methods of the present invention.Type: ApplicationFiled: April 24, 2006Publication date: January 7, 2010Inventors: Frank J. Taddeo, DeeMarie Skulsky, Xin-Min Wang, Kathrin U. Jansen
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Patent number: 7498036Abstract: Synthetic DNA molecules encoding the HPV58 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV58 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV58 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV58 VLPs. The vaccines of the present invention provide effective imnunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and are also useful for treatment of existing HPV infections.Type: GrantFiled: November 10, 2004Date of Patent: March 3, 2009Assignee: Merck & Co., Inc.Inventors: Janine T. Bryan, Michelle K. Brownlow, Loren D. Schultz, Xin-Min Wang, Kathrin U. Jansen
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Publication number: 20090044924Abstract: A challenge of the present invention is to develop a method for repeatedly forming a reverse transferred pattern in a simple and efficient manner onto the surfaces of Zr based, Ti based, Cu based, Ni based and Fe based metallic glass that have supercooled liquid temperatures of not lower than 400° C. and are also required to be molded at not lower than 400° C. (a) An image pattern is converted into bitmap data being mirror reversed with respect to a real image, (b) high energy density light 15 is repeatedly flashed, and the surface of a mold 20 is scanned while one of dot holes 24 is formed by one-time irradiation, to form an image pattern as dots assembled pattern 21 onto the surface of the mold 20 in accordance with the bitmap data, and (c) the dots assembled pattern 21 is reverse-transfer molded onto a metallic glass 1 within a supercooled liquid temperature range Tg-Tx by means of the mold 20 which is for dots assembled pattern formation.Type: ApplicationFiled: October 10, 2006Publication date: February 19, 2009Applicant: NGK INSULATORS, LTD.Inventors: Akihisa Inoue, Xin Min Wang, Naokuni Muramatsu, Yoshimasa Kondo, Kenji Kato
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Publication number: 20080193323Abstract: An object of the present invention is to develop a shape memory and superelastic alloy that does not contain nickel, and has superelasticity and shape memory properties even if being subjected to heat treatment in spite of high biocompatibility, moreover having high cold workability. The Ti—Nb—Zr base alloy is comprising an alloy composition consisting of 40 to 60 wt % Ti, 18 to 30 wt % Nb, 18 to 30 wt % Zr, and 0.77 to 3.7 wt % at least one metal additional element selected from Al, Sn, In and Ga. The Ti—Nb—Zr base alloy is a practical alloy in which the principal components form a strong and dense oxidation film to exhibit high biocompatibility, and also the alloy has superelasticity and shape memory properties, high cold workability, and high low-temperature properties.Type: ApplicationFiled: November 18, 2005Publication date: August 14, 2008Applicants: JAPAN BASIC MATERIAL CO., LTD., TOHOKU UNIVERSITYInventors: Xin Min Wang, Akihisa Inoue, Hiroyuki Tada, Tatsue Arakawa
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Patent number: 7211569Abstract: Synthetic DNA molecules encoding papillomavirus proteins are provided. The codons of the synthetic molecules are codons preferred by the projected host cell. The synthetic molecules may be used as a polynucleotide vaccine which provides effective immunoprophylaxis against papillomavirus infection through stimulation of neutralizing antibody and cell-mediated immunity.Type: GrantFiled: December 4, 2003Date of Patent: May 1, 2007Assignee: Merck & Co., Inc.Inventors: Michael P Neeper, William L. McClements, Kathrin U. Jansen, Loren D. Schultz, Ling Chen, Xin-Min Wang
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Publication number: 20070036824Abstract: Synthetic DNA molecules encoding the HPV58 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV58 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV58 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV58 VLPs. The vaccines of the present invention provide effective imnunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and are also useful for treatment of existing HPV infections.Type: ApplicationFiled: November 10, 2004Publication date: February 15, 2007Applicant: MERCK & CO., INC.Inventors: Janine Bryan, Michelle Brownlow, Loren Schultz, Xin-Min Wang, Kathrin Jansen
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Patent number: 7033797Abstract: The invention is a series of synthetic virus-like particles comprising a heterologous conformational epitope useful in the characterization of human papillomavirus infection, and useful to vaccinate individual for protection against HPV 6 and HPV 11 infections, and assays employing the synthetic virus-like particles.Type: GrantFiled: December 16, 2003Date of Patent: April 25, 2006Assignee: Merck & Co., Inc.Inventors: Kathrin U. Jansen, Jessica C. Ling, Steven W. Ludmerer, William L. McClements, Xin-Min Wang
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Patent number: 7001995Abstract: Synthetic DNA molecules encoding papillomavirus proteins are provided. The codons of the synthetic molecules are codons preferred by the projected host cell. The synthetic molecules may be used as a polynucleotide vaccine which provides effective immunoprophylaxis against papillomavirus infection through stimulation of neutralizing antibody and cell-mediated immunity.Type: GrantFiled: August 21, 2000Date of Patent: February 21, 2006Assignee: Merck & Co., Inc.Inventors: Michael P Neeper, William L. McClements, Kathrin U. Jansen, Loren D. Schultz, Ling Chen, Xin-Min Wang
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Publication number: 20050118139Abstract: Cell-mediated immune response to a papillomavirus infection can be induced by vaccination with DNA encoding papillomavirus E genes. E genes can both prevent the occurrence of papillomavirus disease, and treat disease states. Canine papillomavirus (COPV) E genes which are codon-optimized to enhance expression in host cells are also given.Type: ApplicationFiled: August 19, 2002Publication date: June 2, 2005Inventors: Lingyi Huang, Kathrin Jansen, William McClements, Juanita Monteiro, Loren Schultz, Timothy Tobery, Xin-Min Wang, Ling Chen
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Publication number: 20050075303Abstract: Synthetic DNA molecules encoding papillomavirus proteins are provided. The codons of the synthetic molecules are codons preferred by the projected host cell. The synthetic molecules may be used as a polynucleotide vaccine which provides effective immunoprophylaxis against papillomavirus infection through stimulation of neutralizing antibody and cell-mediated immunity.Type: ApplicationFiled: December 4, 2003Publication date: April 7, 2005Inventors: Michael Neeper, William McClements, Kathrin Jansen, Loren Schultz, Ling Chen, Xin-Min Wang
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Publication number: 20050058988Abstract: The invention is a series of synthetic virus-like particles comprising a heterologous conformational epitope useful in the characterization of human papillomavirus infection, and useful to vaccinate individual for protection against HPV 6 and HPV 11 infections, and assays employing the synthetic virus-like particles.Type: ApplicationFiled: December 16, 2003Publication date: March 17, 2005Inventors: Kathrin Jansen, Jessica Ling, Steven Ludmerer, William McClements, Xin-Min Wang
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Patent number: 6689366Abstract: The invention is a series of synthetic virus-like particles comprising a heterologous conformational epitope useful in the characterization of human papillomavirus infection, and useful to vaccinate individual for protection against HPV 6 and HPV 11 infections, and assays employing the synthetic virus-like particles.Type: GrantFiled: June 4, 2001Date of Patent: February 10, 2004Assignee: Merck & Co., Inc.Inventors: Kathrin U. Jansen, Jessica C. Ling, Steven W. Ludmerer, William L. McClements, Xin-Min Wang
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Patent number: 6667291Abstract: The present invention relates, in part, to newly developed assay for diagnosing cancers, particularly endometrial and mammary, endometriosis and endometrial fibroids along with methods for identifying therapeutic agents that modulate endometrial steroid binding protein II activity for the treatment of the above disorders.Type: GrantFiled: November 3, 1999Date of Patent: December 23, 2003Assignee: SmithKline Beecham CorporationInventors: Carl J Schmidt, Xin-Min Wang
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Publication number: 20030175279Abstract: The presentinvention provides a new method for diagnosing and treating cancers, endometriosis and endometrial fibroids. Further provided are therapeutic agents and pharmaceutical compositions for treating cancers, endometriosis and endometrial fibroids.Type: ApplicationFiled: November 3, 1999Publication date: September 18, 2003Inventors: CARL J SCHMIDT, XIN-MIN WANG