Abstract: A compound, as represented by formula I, as a TLR7 agonist, a method for preparing the compound, and the use of the compound in treating diseases mediated by the TLR7 agonist are provided. Studies on the activity of a human-derived receptor, a TLR7 agonist, show that compounds have a strong agonistic effect on the human-derived receptor, TLR7, and can be used as a foreground compound for treating diseases mediated by the TLR7 agonist.

Abstract: The present disclosure provides a multifunctional sounding device, which includes a lower housing, an upper housing and a sounding unit. The sounding unit includes a frame, a vibration system and a magnetic circuit system. The magnetic circuit system includes a main magnetic circuit, a first auxiliary magnetic circuit and a second auxiliary magnetic circuit. The first auxiliary magnetic circuit includes a first auxiliary magnet and a first auxiliary pole plate. The first auxiliary pole plate fixes the first auxiliary magnet to the upper housing. The multifunctional sounding device also includes a motor assembly, and the motor assembly includes a vibration unit and an elastic member. The multifunctional sounding device of the present disclosure not only simplifies the fixing method of the magnetic circuit system, but also reduces the dimensional accuracy requirements of the magnetic circuit system, meeting the needs of mass production.

Abstract: The present disclosure provides a multifunctional sounding device, which includes a housing body with a containment space, and a sounding unit. The housing body is provided with a sound outlet. The sounding unit includes a frame, a vibration system, and a magnetic circuit system. The multifunctional sounding device also includes a motor assembly accommodated in the containment space. The motor assembly includes a vibration unit having a driving coil. The driving coil is positioned on the side of the first auxiliary magnetic circuit away from the vibration system. The main magnetic circuit and the second auxiliary magnetic circuit are fixed to the vibration unit. The first auxiliary magnetic circuit is fixed to the housing body. Compared with related technologies, the multifunctional sounding device in the present disclosure has a small overall thickness and volume, and has excellent acoustic performance.

Abstract: The present disclosure provides a multifunctional sounding device, including a housing body with a containment space and a sounding unit accommodated in the containment space. The sounding unit includes a frame, a vibration system, and a magnetic circuit system. The sounding device further includes a motor assembly accommodated in the containment space, having a vibration unit with a voice coil disposed on a side of the magnetic circuit system away from the vibration system, and an elastic member suspending the vibration unit in the containment space. The overall thickness of the multifunctional sounding device of the present disclosure is small, the volume is small, and the acoustic performance is excellent; this structure also reduces the cost of parts and assembly costs, making the multifunctional sounding device widely used.

Abstract: Lithium replenishing spaces are disposed on a current collection structure, such that the lithium replenishing spaces communicate with an active layer on one side; and the battery is replenished with lithium by using lithium replenishing agents in the lithium replenishing spaces to offset an irreversible lithium consumption in a cycle process, so as to increase the total capacity and the energy density of the battery. According to the present application, due to average weights MA of corresponding active materials in different distribution regions on the active layer, a sum V0 of internal volumes of lithium replenishing spaces corresponding to each of the distribution regions is controlled in a positively correlated manner based on a change in the average weights of the active materials in the different distribution regions.

Abstract: The present disclosure provides a multifunctional sounding device, which includes a lower housing, an upper housing and a sounding unit. The sounding unit includes a frame, a vibration system and a magnetic circuit system. The magnetic circuit system includes a main magnetic circuit, a first auxiliary magnetic circuit and a second auxiliary magnetic circuit. The first auxiliary magnetic circuit includes a first auxiliary magnet and a first auxiliary pole plate. The multifunctional sounding device also includes a motor assembly having a vibration unit and an elastic member. The main magnetic circuit, the first auxiliary magnetic circuit and the second auxiliary magnetic circuit are respectively fixed in the lower housing or the upper housing. This is not only beneficial to control the magnetic gap, but also improves production accuracy and product consistency.

Abstract: The technology disclosed in this specification pertains to a heat-moisture treated fava bean protein concentrates having between 50% and 73% and a denaturation enthalpy from about 5.5 and 6.5 J/g. This is limited degree of denaturation. The disclosed heat-moisture treated fava bean protein concentrates are useful as emulsifiers, and good solubility in water, and reduced flavor.

Abstract: A method of fabricating a film vibration device, including: photoetching a surface of a silicon wafer to form a circular-hole array; etching an aluminum layer on the silicon wafer; etching the silicon wafer to form a through-hole array to obtain a porous silicon wafer; attaching a polyethylene terephthalate (PET) sheet to a side of the porous silicon wafer; ablating the PET sheet to obtain a porous PET film; attaching a polyvinylidene fluoride (PVDF) film to a lower side of the porous silicon wafer; performing vacuumization above the porous silicon wafer, while heating the PVDF film below the porous silicon wafer to create dome micro-structures on the PVDF film; and laminating the porous PET film on each of two sides of the PVDF film to obtain the film vibration device. This application also provides a cleaning device having the film vibration device.

Abstract: A plasma-facing component of a fusion reactor divertor, including an inner target transition support and a dome transition support which are integrated into an inner target-dome transition support. The inner target-dome transition support and an outer horizontal target transition support are each prepared from two materials. The channel connection inside the inner target-dome transition support and the outer horizontal target transition support is realized through an S-shaped flow channel and a collector box. In V-shaped regions of inner and outer targets, a plasma-facing unit is connected to the collector box in the transition support via a bending tube, and is communicated with a coolant flowing through horizontal and vertical targets through an intermediate flow channel in the transition block. A method of preparing the plasma-facing component is further provided.

Abstract: The application relates to an anti-back-transfer intake structure of a rotating detonation combustion chamber including a Tesla valve communicating with the rotating detonation combustion chamber and arranged at an inlet of the rotating detonation combustion chamber. The Tesla valve includes a casing and a flow passage, the casing is coaxially connected with an outer wall of the rotating detonation combustion chamber, the flow passage is arranged in the casing, and the flow passage has an inlet end for introducing air, and an outlet end connected with an annular passage of the rotating detonation combustion chamber.

Abstract: Provided is an anti-HER3 humanized monoclonal antibody. The antibody binds HER3 antigen, has high affinity and biological activity and low immunogenicity, and is stable in structure. The antibody can be used for preparing drugs for preventing or treating HER3-related diseases.

Abstract: A method for manufacturing a core-shell coaxial gallium nitride (GaN) piezoelectric nanogenerator is provided. A mask covering a center part of a gallium nitride wafer is removed. An electrodeless photoelectrochemical etching is performed on the gallium nitride wafer to form a primary GaN nanowire array on a surface of the gallium nitride wafer. A precious metal layer provided on the surface of the gallium nitride wafer is removed and an alumina layer is deposited on the surface of the gallium nitride wafer to cover the primary GaN nanowire array to obtain a core-shell coaxial GaN nanowire array. A first conductive layer is provided on a flexible substrate to which the core-shell coaxial GaN nanowire array is transferred. A second conductive layer is provided at a top end of the core-shell coaxial GaN nanowire array, and is connected to an external circuit to obtain the core-shell coaxial GaN piezoelectric nanogenerator.

Abstract: A water and gas dual-purpose electric erection aid includes a vacuum barrel and a device bin, which has a seal cover that covers one end of the vacuum barrel and a pump valve pipeline mechanism arranged in the seal cover and used for vacuumizing the vacuum barrel; the device bin is installed with a button control assembly via a support frame; the seal cover is provided with an open groove exposing a button part of the button control assembly and the open groove is tightly attached to the button control assembly; the pump valve pipeline mechanism is communicated with two connection ports formed at the top of the vacuum barrel and a vent cover fixedly arranged on the seal cover through a connecting pipe. The erection aid can be used both in air and underwater. It has good adjuvant treatment and improvement effects on men suffering from sexual dysfunction.

Abstract: An intelligent air curtain system on buses based on computer vision technology is provided, the air curtain system includes a data collection system, an information processing system, a terminal control system, and a terminal broadcast system. The data collection system collects video information in a front area. The information processing system includes an object detection part, a safety judgment part, a return air volume monitoring part, a posture judgment part, and an information calculation part. The object detection part and the safety judgment part judge the safety of a driver. The posture judgment part determines whether a passenger wears a mask properly. The information calculation part is configured to calculate a facial temperature of the passenger and transmit the facial temperature to the terminal control system and the terminal broadcast system. The terminal control system is configured to control an air curtain. The terminal broadcast system is configured for reminder.

Abstract: Disclosed herein are methods, compositions, and kits for rapid molecular diagnostics that integrate sample processing (including sample inactivation, sample lysis, nucleases inhibition, nucleic acid extraction, nucleic acid stabilization), nucleic acid amplification, and result readout into a single unified-one-pot reaction, enabling the molecular assay to be completed with minimal steps inside a single reaction vessel.

Abstract: A user equipment (UE) device may include a processor configured to obtain a configuration specification for at least one discontinuous transmission parameter, wherein the configuration specification includes different values for at least two different Quality of Service (QoS) classes. The processor may be further configured to detect uplink data that is to be sent by the UE device to a device via a base station; determine a QoS class associated with the uplink data; select a value for the at least one discontinuous transmission parameter based on the configuration specification and the determined QoS class associated with the uplink data; and send the uplink data to the base station based on the selected value for the at least one discontinuous transmission parameter.

Abstract: A shift register and a display panel. The shift register includes an output adjustment module, a trigger write module, and a node adjustment module. A first terminal of the output adjustment module inputs a first clock signal. A second terminal of the output adjustment module inputs a first power signal. The output adjustment module is configured to adjust the shift register to output the first clock signal or the first power signal according to the signal on a first control node and the signal on a second control node of the output adjustment module. The trigger write module is configured to write a trigger signal to the second control node according to the clock signal of the control terminal of the trigger write module. The node adjustment module is configured to adjust the signal on the first control node.

Abstract: An information reporting and receiving method, a terminal device and a network device are provided in the present disclosure. The information reporting method, performed by the terminal device, which includes: acquiring resource configuration information for channel measurement, where the resource configuration information indicates at least two resource groups and resources included in each resource group; determining reporting configuration of channel state information (CSI); acquiring at least one CSI according to the resource configuration information and the reporting configuration; sending a target CSI to a network device according to the at least one CSI, where the target CSI includes first information, and the first information indicates a target resource and a type of transmission mode recommended by a terminal, where the target resource includes: at least one resource or a combination of at least two resources.

Abstract: An apparatus includes: a receiver configured to: receive a downlink signal related to beam failure recovery, and receive a downlink reference signal; and a transmitter configured to, after receiving the downlink signal, transmit a first uplink signal on a first cell by using a first spatial filter identical to a second spatial filter receiving the downlink reference signal.

Abstract: According to an aspect, a method of restoring a computing session includes receiving, over a network, session data from a server computer, where the session data includes information about at least one session item that is active during a computing session of a first computing device. The at least one session item includes at least one of a web application or a native application. The method includes restoring the at least one session item of the computing session on a second computing device based on the session data, where the at least one session item is arranged on a user interface of the second computing device according to a display arrangement that corresponds to a display arrangement of the at least one session item on a user interface of the first computing device.