Patents by Inventor Xing-Ping Liu

Xing-Ping Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic compounds
    Publication number: 20060276491
    Abstract: The invention provides novel JAK-3 inhibitors that are useful for treating leukemia and lymphoma. The compounds are also useful to treat or prevent skin cancer, as well as sunburn and UVB-induced skin inflammation. In addition, the compounds of the present invention prevent the immunosuppressive effects of UVB radiation, and are useful to treat or prevent autoimmune diseases, inflammation, and transplant rejection. The invention also provides pharmaceutical compositions comprising compounds of the invention, as well as therapeutic methods for their use.
    Type: Application
    Filed: November 17, 2003
    Publication date: December 7, 2006
    Applicant: Parker Hughes Institute
    Inventors: Fatih Uckun, Elise Sudbeck, Marina Cetkovic, Ravi Malaviya, Xing-Ping Liu
  • Haloanilino quinazolines and therapeutic use thereof
    Patent number: 7038049
    Abstract: The present disclosure includes compounds, for example a compound according to formula I or a pharmaceutically acceptable salt thereof. The compounds of the present disclosure are useful in methods of treating cancerous conditions.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: May 2, 2006
    Assignee: Parker Hughes Institute
    Inventors: Fatih M. Uckun, Xing-Ping Liu, Rama Krishna Narla
  • Quinazolines and therapeutic use thereof
    Publication number: 20050075353
    Abstract: Quinazoline compounds and methods for the treatment of cancer and for the treatment of allergic reactions.
    Type: Application
    Filed: May 24, 2004
    Publication date: April 7, 2005
    Applicant: Parker Hughes Institute
    Inventors: Fatih Uckun, Xing-Ping Liu, Rama Narla
  • Therapeutic compounds
    Publication number: 20040192711
    Abstract: The invention provides novel JAK-3 inhibitors that are useful for treating leukemia and lymphoma. The compounds are also useful to treat or prevent skin cancer, as well as sunburn and UVB-induced skin inflammation. In addition, the compounds of the present invention prevent the immunosuppressive effects of UVB radiation, and are useful to treat or prevent autoimmune diseases, inflammation, and transplant rejection. The invention also provides pharmaceutical compositions comprising compounds of the invention, as well as therapeutic methods for their use.
    Type: Application
    Filed: November 17, 2003
    Publication date: September 30, 2004
    Applicant: Parker Hughes Institute
    Inventors: Fatih M. Uckun, Elise A. Sudbeck, Marina Cetkovic, Ravi Malaviya, Xing-Ping Liu
  • 6,7-Dimethoxyquinazolines and therapeutic use thereof
    Publication number: 20040039002
    Abstract: Quinazoline compounds and methods for the treatment of cancer and for the treatment of allergic reactions.
    Type: Application
    Filed: June 5, 2003
    Publication date: February 26, 2004
    Applicant: Parker Hughes Institute
    Inventors: Fatih M. Uckun, Xing-Ping Liu, Rama Krishna Narla
  • 6,7-dimethoxyquinazolines and therapeutic use thereof
    Patent number: 6638939
    Abstract: Quinazoline compounds and methods for the treatment of cancer and for the treatment of allergic reactions.
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: October 28, 2003
    Assignee: Parker Hughes Institute
    Inventors: Fatih M. Uckun, Xing-Ping Liu, Rama Krishna Narla
  • Estrogens for treating ALS
    Patent number: 6592845
    Abstract: A method for preventing and treating ALS by administering a phytoestrogen, preferably genistein.
    Type: Grant
    Filed: November 2, 2001
    Date of Patent: July 15, 2003
    Assignee: Parker Hughes Institute
    Inventors: Fatih M. Uckun, Vuoung N. Trieu, Xing-Ping Liu
  • Quinazolines for treating brain tumor
    Patent number: 6552027
    Abstract: Novel substituted quinozaline compounds and conjugates useful to inhibit the growth of brain tumor cells and to inhibit adhesion and migration of brain tumor cells. The compounds of the invention include 4-(3′-bromo-4′-hydroxy phenyl)-amino-6,7-dimethoxyquinazoline and this compound covalently bound to EGF.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: April 22, 2003
    Assignee: Parker Hughes Institute
    Inventors: Fatih M. Uckun, Rama Krishna Narla, Xing-Ping Liu
  • Dimethoxy quinazolines for treating diabetes
    Patent number: 6495556
    Abstract: The invention provides novel JAK-3 inhibitors that are useful for treating leukemia and lymphoma. The compounds are also useful to treat or prevent skin cancer, as well as sunburn and UVB-induced skin inflammation. In addition, the compounds of the present invention prevent the immunosuppressive effects of UVB radiation, and are useful to treat or prevent autoimmune diseases, inflammation, and transplant rejection. The invention also provides pharmaceutical compositions comprising compounds of the invention, as well as therapeutic methods for their use.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: December 17, 2002
    Assignee: Parker Hughes Institute
    Inventors: Fatih M. Uckun, Elise A. Sudbeck, Marina Cetkovic, Ravi Malaviya, Xing-Ping Liu
  • Organic arsenic compounds
    Patent number: 6482816
    Abstract: Novel organic arsenic compounds are described as cytotoxic agents with potent anti-tumor activity against cancer cells and particularly, with regard to human leukemic cells and breast cancer cells.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: November 19, 2002
    Assignee: Parker Hughes Institute
    Inventors: Faith M. Uckun, Xing-Ping Liu
  • Organic-arsenic compounds
    Patent number: 6482815
    Abstract: Novel organic arsenic compounds are described as cytotoxic agents with potent anti-tumor activity against cancer cells and particularly, with regard to human leukemic cells and breast cancer cells.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: November 19, 2002
    Assignee: Parker Hughes Institute
    Inventors: Fatih M. Uckun, Xing-Ping Liu
  • Quinazolines for treating brain tumor
    Publication number: 20020161226
    Abstract: Novel substituted quinozaline compounds and conjugates useful to inhibit the growth of brain tumor cells and to inhibit adhesion and migration of brain tumor cells. The compounds of the invention include 4-(3′-bromo-4′-hydroxy phenyl)-amino-6,7-dimethoxyquinazoline and this compound covalently bound to EGF.
    Type: Application
    Filed: July 11, 2001
    Publication date: October 31, 2002
    Applicant: Parker Hughes Institute
    Inventors: Fatih M. Uckun, Rama Krishna Narla, Xing-Ping Liu
  • Therapeutic compounds
    Patent number: 6469013
    Abstract: The invention provides novel JAK-3 inhibitors that are useful for treating leukemia and lymphoma. The compounds are also useful to treat or prevent skin cancer, as well as sunburn and UVB-induced skin inflammation. In addition, the compounds of the present invention prevent the immunosuppressive effects of UVB radiation, and are useful to treat or prevent autoimmune diseases, inflammation, and transplant rejection. The invention also provides pharmaceutical compositions comprising compounds of the invention, as well as therapeutic methods for their use.
    Type: Grant
    Filed: May 16, 2001
    Date of Patent: October 22, 2002
    Assignee: Parker Hughes Institute
    Inventors: Fatih M. Uckun, Elise A. Sudbeck, Marina Cetkovic, Ravi Malaviya, Xing-Ping Liu
  • Quinazolines and therapeutic use thereof
    Publication number: 20020137757
    Abstract: Quinazoline compounds and methods for the treatment of cancer and for the treatment of allergic reactions.
    Type: Application
    Filed: August 7, 2001
    Publication date: September 26, 2002
    Applicant: Parker Hughes Institute
    Inventors: Fatih M. Uckun, Xing-Ping Liu, Rama Krishna Narla
  • Lipid lowering quinazoline dietary supplement composition
    Patent number: 6410545
    Abstract: A novel carbonyl-substituted quinazoline, preferably 4-(3′-bromobenzoyl)-6,7-dimethoxyquinazoline (WHI-P164), and methods for lowering blood cholesterol, including reducing total cholesterol and LDL-cholesterol levels by administration of the carbonyl quinazolines and compositions thereof.
    Type: Grant
    Filed: June 26, 2001
    Date of Patent: June 25, 2002
    Assignee: Parker Hughes Institute
    Inventors: Fatih M. Uckun, Vuong N. Trieu, Xing-Ping Liu
  • Estrogens for treating ALS
    Publication number: 20020052385
    Abstract: A method for preventing and treating ALS by administering a phytoestrogen, preferably genistein.
    Type: Application
    Filed: November 2, 2001
    Publication date: May 2, 2002
    Applicant: Parker Hughes Institute
    Inventors: Fatih M. Uckun, Vuoung N. Trieu, Xing-Ping Liu
  • Therapeutic compounds
    Publication number: 20020042513
    Abstract: The invention provides novel JAK-3 inhibitors that are useful for treating leukemia and lymphoma. The compounds are also useful to treat or prevent skin cancer, as well as sunburn and UVB-induced skin inflammation. In addition, the compounds of the present invention prevent the immunosuppressive effects of UVB radiation, and are useful to treat or prevent autoimmune diseases, inflammation, and transplant rejection. The invention also provides pharmaceutical compositions comprising compounds of the invention, as well as therapeutic methods for their use.
    Type: Application
    Filed: May 16, 2001
    Publication date: April 11, 2002
    Applicant: Parker Hughes Institute
    Inventors: Fatih M. Uckun, Elise A. Sudbeck, Marina Cetkovic, Ravi Malaviya, Xing-Ping Liu
  • 6,7-Dimethoxyquinazolines and therapeutic use thereof
    Patent number: 6358962
    Abstract: Quinazoline compounds and methods for the treatment of cancer and for the treatment of allergic reactions.
    Type: Grant
    Filed: February 8, 2001
    Date of Patent: March 19, 2002
    Assignee: Parker Hughes Institute
    Inventors: Fatih M. Uckun, Xing-Ping Liu, Rama Krishna Narla
  • Lipid-lowering quinazoline derivative
    Patent number: 6355645
    Abstract: A novel carbonyl-substituted quinazoline, preferably 4-(3′-bromobenzoyl)-6,7-dimethoxyquinazoline (WHI-P164), and methods for lowering blood cholesterol, including reducing total cholesterol and LDL-cholesterol levels by administration of the carbonyl quinazolines and compositions thereof.
    Type: Grant
    Filed: January 8, 2001
    Date of Patent: March 12, 2002
    Assignee: Parker Hughes Institute
    Inventors: Fatih M. Uckun, Vuong N. Trieu, Xing-Ping Liu
  • Estrogens for treating ALS
    Patent number: 6334998
    Abstract: A method for preventing and treating ALS by administering a phytoestrogen, preferably genistein.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: January 1, 2002
    Assignee: Parker Hughes Institute
    Inventors: Faith M. Uckun, Vuoung N. Trieu, Xing-Ping Liu