Patents by Inventor Xingchun Han

Xingchun Han has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel Tetrahydropyridopyrimidines and Tetrahydropyridopyridines for the Treatment and Prophylaxis of Hepatitis B Virus Infection
    Publication number: 20160326167
    Abstract: The present invention provides novel compounds having the general formula: wherein R1, R2, U, W, X, Y and Z are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: May 3, 2016
    Publication date: November 10, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling Cheng, Xingchun Han, Min Jiang, Jianhua Wang, Min Wang, Yongguang Wang, Song Yang
  • NOVEL DIHYDROQUINOLIZINONES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20160296515
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5 and R6 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: June 21, 2016
    Publication date: October 13, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Xingchun Han, Hassan Javanbakht, Min Jiang, Chungen Liang, Jianping Wang, Yongguang Wang, Zhanguo Wang, Robert James Weikert, Song Yang, Chengang Zhou
  • Dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection
    Patent number: 9458153
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5 and R6 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: October 4, 2016
    Assignee: Hoffmann-La Roche INC.
    Inventors: Xingchun Han, Hassan Javanbakht, Min Jiang, Chungen Liang, Jianping Wang, Yongguang Wang, Zhanguo Wang, Robert James Weikert, Song Yang, Chengang Zhou
  • NOVEL PYRAZINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES
    Publication number: 20160237090
    Abstract: The present invention relates to compounds of the formula (I), or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R4 are as described above. The compounds may be useful for the treatment or prophylaxis of hepatitis B virus infection.
    Type: Application
    Filed: January 15, 2016
    Publication date: August 18, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Taishan HU, Xingchun HAN, Buyu KOU, Hong SHEN, Shixiang YAN, Zhisen ZHANGHAI
  • Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection
    Publication number: 20160207914
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5 and R6 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: January 30, 2015
    Publication date: July 21, 2016
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Xingchun Han, Hassan Javanbakht, Min Jiang, Chungen Liang, Jianping Wang, Yongguang Wang, Zhanguo Wang, Robert James Weikert, Song Yang, Chengang Zhou
  • Novel 6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection
    Publication number: 20160122344
    Abstract: The invention provides novel compounds having the general formula: wherein R1 to R6, W and X are as described herein and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: October 29, 2015
    Publication date: May 5, 2016
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Xingchun Han, Min Jiang, Jianhua Wang, Chengang Zhou, Yongguang Wang, Song Yang
  • NOVEL BI-RING PHENYL-PYRIDINES/PYRAZINES FOR THE TREATMENT OF CANCER
    Publication number: 20150266878
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2 and R3 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: June 10, 2015
    Publication date: September 24, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Song Yang, Zhanling Cheng, Chengang Zhou, Min Jiang, Jianhua Wang, Min Wang, Xingchun Han
  • Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection
    Publication number: 20150210682
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5 and R6 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: January 30, 2015
    Publication date: July 30, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Xingchun Han, Hassan Javanbakht, Min Jiang, Chungen Liang, Jianping Wang, Yongguang Wang, Zhanguo Wang, Robert James Weikert, Song Yang, Chengang Zhou
  • 3,3?-spiroindolinone derivatives
    Patent number: 8076482
    Abstract: There are provided compounds of the formula or a pharmaceutically acceptable salt or ester thereof wherein X, Y, W, W?, V, V?, V?, R1, R2 and R3 are as herein described. The compounds have utility as antiproliferative agents, especially, as anticancer agents.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: December 13, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Xingchun Han, Song Yang, Zhuming Zhang
  • Spiroindolinone pyridine derivatives
    Patent number: 7928233
    Abstract: There are provided compounds of the formula or a pharmaceutically acceptable salt, ester or enantiomer thereof wherein W, X, Y, V, R1 and R2 are as described herein. The compounds have utility as antiproliferative agents, especially, as anticancer agents.
    Type: Grant
    Filed: January 12, 2010
    Date of Patent: April 19, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Xingchun Han, Song Yang, Zhuming Zhang
  • 3,3'-Spiroindolinone Derivatives
    Publication number: 20100273819
    Abstract: There are provided compounds of the formula or a pharmaceutically acceptable salt or ester thereof wherein X, Y, W, W?, V, V?, V?, R1, R2 and R3 are as herein described. The compounds have utility as antiproliferative agents, especially, as anticancer agents.
    Type: Application
    Filed: March 29, 2010
    Publication date: October 28, 2010
    Inventors: Li Chen, Xingchun Han, Song Yang, Zhuming Zhang
  • Spiroindolinone derivatives
    Patent number: 7776875
    Abstract: There are provided compounds of the formula and pharmaceutically acceptable salts and esters and enantiomers thereof wherein W, X, X?, Y, V, V?, A, B and R are as described herein. The compounds have utility as antiproliferative agents, especially, as anticancer agents.
    Type: Grant
    Filed: November 18, 2008
    Date of Patent: August 17, 2010
    Assignee: Hoffman-La Roche Inc.
    Inventors: Li Chen, Xingchun Han, Yun He, Song Yang, Zhuming Zhang
  • SPIROINDOLINONE PYRIDINE DERIVATIVES
    Publication number: 20100204257
    Abstract: There are provided compounds of the formula or a pharmaceutically acceptable salt, ester or enantiomer thereof wherein W, X, Y, V, R1 and R2 are as described herein. The compounds have utility as antiproliferative agents, especially, as anticancer agents.
    Type: Application
    Filed: January 12, 2010
    Publication date: August 12, 2010
    Inventors: Li Chen, Xingchun Han, Song Yang, Zhuming Zhang
  • SPIROINDOLINONE DERIVATIVE PRODRUGS
    Publication number: 20100190814
    Abstract: There are provided compounds of the formula and pharmaceutically acceptable salts and esters and enantiomers thereof wherein X, Y, V, R1, R2 and R are as described herein. The compounds have utility as antiproliferative agents, especially, as anticancer agents.
    Type: Application
    Filed: January 12, 2010
    Publication date: July 29, 2010
    Inventors: Li Chen, Xingchun Han, Lisha Wang, Min Wang, Song Yang, Zhuming Zhang
  • Spiroindolinone Derivatives
    Publication number: 20090163512
    Abstract: There are provided compounds of the formula and pharmaceutically acceptable salts and esters and enantiomers thereof wherein W, X, X?, Y, V, V?, A, B and R are as described herein. The compounds have utility as antiproliferative agents, especially, as anticancer agents.
    Type: Application
    Filed: November 18, 2008
    Publication date: June 25, 2009
    Inventors: Li Chen, Xingchun Han, Yun He, Song Yang, Zhuming Zhang