Abstract: Presently provided are inhibitors of TD02 and IDO1 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2,3 dioxygenase and indoleamine 2,3-dioxygenase 1; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.

Abstract: The invention belongs to the technical field of material synthesis, and discloses a nitrogen-doped hollow cobaltosic oxide and a preparation method and application thereof. A chemical formula of the nitrogen-doped hollow cobaltosic oxide is Co3O4—COF-T-D@C—N; and the COF-T-D is a covalent organic framework. Due to an open hollow structure, the nitrogen-doped hollow cobaltosic oxide of the invention has a large specific surface area, thus having a large contact area with an electrolyte, which is convenient for lithium ions to transport therein. The open hollow structure also prevents a volume effect from being generated during charging and discharging, and nitrogen is introduced for doping, so that granules can be gradually activated to increase the specific surface area and active sites, a discharge (cycle) stability of the material is improved, and a rate performance of the material is improved.

Abstract: The present disclosure discloses a preparation method of a hard carbon (HC) anode material and use thereof. The preparation method includes the following steps: mixing a substance A, a first alcohol liquid, and an oxidant to obtain a peroxide gel of the substance A, and dissolving a substance B in a second alcohol liquid to obtain an amino-containing solution; mixing the peroxide gel of the substance A with the amino-containing solution to allow a reaction to obtain a post-reaction slurry; and lyophilizing the post-reaction slurry to obtain a dry powder, subjecting the dry powder to calcination in a protective atmosphere to obtain a calcined material, soaking the calcined material in an acid liquid, and water-washing and drying to obtain the HC anode material.

Abstract: Disclosed are a pre-lithiated lithium ion positive electrode material, a preparation method therefor and use thereof. The lithium ion positive electrode material has a chemical formula of Li2O/[A(3-x)Mex]1/3-LiAO2, wherein A comprises M, and wherein M is at least one of Ni, Co, and Mn; and wherein Me is at least one of Ni, Mn, Al, Mg, Ti, Zr, Y, Mo, W, Na, Ce, Cr, Zn or Fe; and wherein 0<x<0.1. The material is co-doped with multiple elements, and these elements act synergistically to inhibit the irreversible phase change at a high voltage and improve the stability of the structure of a substrate. The spinel phase A(3-x)MexO4 structure contains the doping elements, which work together to improve the interfacial activity of the material and introduce more electrochemically active sites.

Abstract: The invention belongs to the technical field of batteries, and discloses a preparation method and application of a lithium cobalt oxide soft-pack battery. The preparation method comprises the following steps: preparation of a lithium cobalt oxide positive electrode; preparation of a graphite negative electrode; preparation of an aluminum plastic film; screening and tab welding the positive and negative electrode, then winding core and packing, injecting an electrolyte to a resulting pack, perform first sealing, formation, second sealing; followed by capacity grading to obtain the lithium cobalt oxide soft pack battery. The preparation method for the lithium cobalt oxide soft-pack battery in a laboratory environment at room temperature provided by the present invention has simple operation and low environmental requirements, can be used in laboratories without dry room conditions, and reduces research and development cost and laboratory maintenance cost.

Abstract: The invention belongs to the technical field of lithium ion battery materials, and discloses a fast ionic conductor coated lithium-transition metal oxide material having a chemical formula of (1?x)Li1+a (Ni(1?m?n)ConMnm) 1?bMbO2·xLicAldTieM?fM?g (PO4)3 and a preparation method thereof. The fast ionic conductor coated lithium-transition metal oxide material of the present invention has lower impedance, excellent cycle performance and safety performance under high voltage, especially when the charging voltage is greater than 4.62V, 4.65V, or higher. The Lithium-transition metal oxide can be obtained by a primary calcination, and the final product of lithium-transition metal oxide material coated with fast ionic conductor can be obtained by a secondary calcination.

Abstract: Disclosed are a pre-lithiated lithium ion positive electrode material, a preparation method therefor and use thereof. The lithium ion positive electrode material has a chemical formula of Li2O/[A(3-x)Mex]1/3-LiAO2, wherein A comprises M, and wherein M is at least one of Ni, Co, and Mn; and wherein Me is at least one of Ni, Mn, Al, Mg, Ti, Zr, Y, Mo, W, Na, Ce, Cr, Zn or Fe; and wherein 0 < × < 0.1. The material is co-doped with multiple elements, and these elements act synergistically to inhibit the irreversible phase change at a high voltage and improve the stability of the structure of a substrate. The spinel phase A(3-x)MexO4 structure contains the doping elements, which work together to improve the interfacial activity of the material and introduce more electrochemically active sites.

Abstract: Disclosed are a sagger for sintering lithium composite transition metal oxide and a preparation method thereof. The sagger includes a substrate layer and a shallow layer on a surface of the substrate layer, and a coating layer. The substrate layer is prepared from the following raw materials: silicon carbide, magnesia-alumina spinel, aluminum oxide-magnesium oxide-yttrium oxide composite fiber, zircon powder and a binding agent; the shallow layer is prepared from the following raw materials: silicon carbide, magnesia-alumina spinel, aluminum oxide-titanium oxide composite fiber, yttrium oxide-zirconium oxide composite fiber and a binding agent; and the coating layer is prepared from the following raw materials: silicon carbide, magnesia-alumina spinel, magnesium oxide, zirconium oxide fiber, lithium composite transition metal oxide powder and a binding agent. The sagger of the present disclosure has properties of good corrosion resistance and a small coefficient of thermal expansion.

Abstract: A medical cutting assembly (10) and a volume reduction catheter system are provided. The medical cutting assembly (10) includes a cutter head (101) and a limiting member (102) connected to the cutter head (101), where the cutter head (101) includes a delivery portion (1012); the limiting member (102) includes a decomposing portion (1021); and when the cutter head (101) and the limiting member (102) rotate relative to each other, the decomposing portion (1021) extends through the delivery portion (1012). The volume reduction catheter system includes a cutting section and a transfer section. The delivery portion (1012) can transfer excess tissue cut by the cutter head (101) from a distal end to a proximal end. The limiting member (102) is provided with the decomposing portion (1021).

Abstract: A combination automobile detailing machine having a battery powered drive mechanism which powers three different interchangeable accessory attachments for detailing an automobile.