Patents by Inventor Xinhua Li

Xinhua Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7041280
    Abstract: Disclosed are polymers comprising one or more phenyl boronate ester, boronamide or boronate thioester groups. The phenyl boronate ester, boronamide and boronate thioester groups are represented by one of the following structural formulas: Ar in Structural Formulas (I) and (II) is substituted or unsubstituted; and each Z is —O—, —NH— or —S— and is independently selected. Pharmaceutically acceptable salts of the polymer are also included. The aryl boronate ester, boronamide or boronate thioester can be cleaved to release the corresponding aryl boronic acid. Also disclosed are pharmaceutical compositions comprising the polymers of the present invention and a pharmaceutically acceptable carrier or diluent; and methods of treating a subject for obesity with the polymers of the present invention.
    Type: Grant
    Filed: June 27, 2002
    Date of Patent: May 9, 2006
    Assignee: Genzyme Corporation
    Inventors: Stephen Randall Holmes-Farley, W. Harry Mandeville, III, Pradeep K. Dhal, Chad Cori Huval, Xinhua Li, Steven Craig Polomoscanik
  • Publication number: 20050107336
    Abstract: Disclosed is a phenyl boronic acid compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aryl group. Z and Z? are independently —O—. —NH— or —S—. X is an electron withdrawing group. R is a substituted or unsubstituted straight chained hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups and Y is —H, an amine, —[NH—(CH2)q]r—NH2, halogen, —CF3, thiol, ammonium, alcohol, —COOH, —SO3H, —OSO3H or phosphonium group covalently bonded to the terminal position of R. Each —NH— in —[NH—(CH2)q]r—NH2 is optionally N-alkylated or N,N-dialkylated and —NH2 in —[NH—(CH2)q]r—NH2 is optionally N-alkylated, N,N-dialkylated or N,N,N-trialkylated. q is an integer from 2 to about 10 and r is an integer from 1 to about 5.
    Type: Application
    Filed: December 30, 2004
    Publication date: May 19, 2005
    Inventors: Stephen Holmes-Farley, W. Mandeville, Pradeep Dhal, Chad Huval, Xinhua Li
  • Patent number: 6858592
    Abstract: Disclosed is a phenyl boronic acid compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aryl group. Z and Z? are independently —O—. —NH— or —S—. X is an electron withdrawing group. R is a substituted or unsubstituted straight chained hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups and Y is —H, an amine, —[NH—(CH2)q]r—NH2, halogen, —CF3, thiol ammonium, alcohol, —COOH, —SO3H, —OSO3H or phosphonium group covalently bonded to the terminal position of R. Each —NH— in —[NH—(CH2)q]r—NH2 is optionally N-alkylated or N,N-dialkylated and —NH2 in —[NH—(CH2)q]r—NH2 is optionally N-alkylated, N,N-dialkylated or N,N,N-trialkylated. q is an integer from 2 to about 10 and r is an integer from 1 to about 5.
    Type: Grant
    Filed: June 27, 2002
    Date of Patent: February 22, 2005
    Assignee: Genzyme Corporation
    Inventors: Stephen Randall Holmes-Farley, W. Harry Mandeville, III, Pradeep K. Dhal, Chad Cori Huval, Xinhua Li
  • Publication number: 20030064963
    Abstract: Disclosed is a phenyl boronic acid compound represented by Structural Formula (I): 1
    Type: Application
    Filed: June 27, 2002
    Publication date: April 3, 2003
    Applicant: GelTex Pharmaceuticals, Inc.
    Inventors: Stephen Randall Holmes-Farley, W. Harry Mandeville, Pradeep K. Dhal, Chad Cori Huval, Xinhua Li
  • Publication number: 20030059399
    Abstract: Disclosed are polymers comprising one or more phenyl boronate ester, boronamide or boronate thioester groups.
    Type: Application
    Filed: June 27, 2002
    Publication date: March 27, 2003
    Applicant: GelTex Pharmaceuticals, Inc.
    Inventors: Stephen Randall Holmes-Farley, W. Harry Mandeville, Pradeep K. Dhal, Chad Cori Huval, Xinhua Li, Steven Craig Polomoscanik
  • Patent number: 5375657
    Abstract: The invention relates to oil recovery equipment improved from existing chain oil-well pumping units. Double suspending cables, double balance flexible cables and a counterweight structure without inertial load are used in the invention. There are guide buffer devices and a buffer eccentric regulation shaft coupling in the apparatus according to the invention. Consequently, the load distribution and the stressed condition are more reasonable, the structure is simplified and reliable, and power is obviously economized. The invention has the striking strong points mentioned above in recovering condensed oil, high-condensed oil and bathhypelagic oil.
    Type: Grant
    Filed: July 6, 1993
    Date of Patent: December 27, 1994
    Assignee: Oil Production Technology Institute
    Inventors: Chaoying Shi, Kaili Song, Xinhua Li, Guanggi Gao, Juanhuan Yang, Quingkun Zeng