Abstract: A conjugate compounds or pharmaceutically acceptable salt thereof, comprises a payload and two or more kinds of cell-interacting molecules. The cell-interacting molecules are ligands capable of specifically binding to a cell surface receptor. A method of treating diseases, comprises delivering a payload to a subject.

Abstract: An anti-ANGPTL3 antibody or an antigen-binding fragment thereof. The present invention provides an anti-ANGPTL3 antibody or an antigen-binding fragment thereof, wherein a heavy chain variable region includes complementarity determining regions (CDRs), including CDR-H1 having an amino acid sequence as set forth in SEQ ID No. 1, CDR-H2 having an amino acid sequence as set forth in SEQ ID No. 2, and CDR-H3 having an amino acid sequence as set forth in SEQ ID No. 3; and the CDRs of a light chain variable region includes CDR-L1 having an amino acid sequence as set forth in SEQ ID No. 4, CDR-L2 having an amino acid sequence as set forth in SEQ ID No. 5, and CDR-L3 having an amino acid sequence as set forth in SEQ ID No. 6. The antibody or the antigen-binding fragment thereof provided in the present invention can specifically recognize ANGPTL3.

Abstract: Recombinant protein coronavirus antigens and vaccine compositions using the same, include a recombinant protein that is a single-chain (SC) viral membrane protein complex derived from the spike (S), envelop (E) and membrane (M) protein of a coronaviruses such as SARS-CoV-2, the causal agent for COVID-19. Methods for immunization of a subject using the vaccine compositions treats or prevents clinical signs caused by coronaviruses infection.

Abstract: The present invention provides a Lactococcus lactis subsp. lactis A32, derived product and use thereof, the present invention falls in the technical field of microorganisms. In the present invention, the Lactococcus lactis subsp. lactis A32 is obtainable by compound mutation on the basis of the original strain L. lactis lxl. Experiments showed that, compared with nisin titre of the original strain L. lactis lxl, the Lactococcus lactis subsp. lactis A32 has high nisin yield, and the nisin titre has been improved for 3˜4 times (over 5066.58 IU/mL); in the meanwhile, the growth curve of the Lactococcus lactis subsp. lactis A32 is slightly longer than the original strain L. lactis lxl and biomass peaks of them are basically consistent. The present invention has laid a foundation for large scale production of nisin.

Abstract: Described herein are compositions and methods for the prevention of pathogens such as conditions in an animal (e.g., a subject). In some cases, a composition or method described herein can comprise a liposome, which may be used to encapsulate one or more STING agonists. In some cases, a liposome of a composition or method described herein may comprise one or more antigens attached to, integrated into, or associated with a liposomal membrane of the liposome.

Abstract: Compounds disclosed herein have been shown to bind to the transferrin receptor making them capable of crossing the blood-brain barrier (BBB) and useful for treating diseases or disorders of the brain, such as cancer, ischemic stroke, Alzheimer's disease, or Parkinson's disease.

Abstract: An information transmission apparatus for logging while drilling comprises a hollow drilling rod and at least one cable. The drilling rod comprises at least one first drilling rod member and at least one second drilling rod member spliced to each other alternately. The first drilling rod member comprises a through hole, and the second drilling rod member comprises a stepped hole. The cable comprises a fixed end, a connected end, and a folded portion connect the fixed end to the connected end. Each of the cables is fixed in the stepped hole through a fixed end or is connected to a connected end of an adjacent cable. The connected end may be stretched along the stepped hole, and stretched through the through hole to be electrically connected to a logging instrument or a fixed end of the adjacent cable. The apparatus provides protection for a cable through a hollow drilling rod, thereby improving the transmission reliability.

Abstract: The invention provides a metal alkoxide complex of Formula (I), wherein X, M, R1, R2, R3, m, n, y and z are as defined in the Description. The invention also provides a catalyst composition comprising the metal alkoxide complex and a hydroxy-containing compound, wherein the molar ratio of the metal alkoxide complex to the hydroxy-containing compound is 1:0.1-1000. The invention also provides a production method of poly-?-caprolactone or polyactide, wherein an ?-caprolactone monomer or a lactide monomer is reacted in the presence of the metal alkoxide complex or catalyst composition to obtain poly-?-caprolactone or polylactide. The metal alkoxide complex and the catalyst composition thereof can be used to catalyze the synthesis of poly-?-caprolactone or polylactide with a high efficiency.

Abstract: An information transmission apparatus for logging while drilling comprises a hollow drilling rod and at least one cable. The drilling rod comprises at least one first drilling rod member and at least one second drilling rod member spliced to each other alternately. The first drilling rod member comprises a through hole, and the second drilling rod member comprises a stepped hole. The cable comprises a fixed end, a connected end, and a folded portion connect the fixed end to the connected end. Each of the cables is fixed in the stepped hole through a fixed end or is connected to a connected end of an adjacent cable. The connected end may be stretched along the stepped hole, and stretched through the through hole to be electrically connected to a logging instrument or a fixed end of the adjacent cable. The apparatus provides protection for a cable through a hollow drilling rod, thereby improving the transmission reliability.

Abstract: The invention provides a metal alkoxide complex of Formula (I), wherein X, M, R1, R2, R3, m, n, y and z are as defined in the Description. The invention also provides a catalyst composition comprising the metal alkoxide complex and a hydroxy-containing compound, wherein the molar ratio of the metal alkoxide complex to the hydroxy-containing compound is 1:01-1000. The invention also provides a production method of poly-?- caprolactone or polyactide, wherein an ?-caprolactone monomer or a lactide monomer is reacted in the presence of the metal alkoxide complex or catalyst composition to obtain poly-?-caprolactone or polylactide. The metal alkoxide complex and the catalyst composition thereof can be used to catalyze the synthesis of poly-?- caprolactone or polylactide with a high efficiency.

Abstract: An isoprene or butadiene cis 1,4-selective polymerization catalyst system together with its polymerization method is provided. This catalyst system is composed of NCN-imine pincer type rare earth metal complex of formula [2,6-(CH?N—R1)2-4-R2-1-C6H2]LnX2(THF)n and alkylating reagent. In an hydrocarbon solvent or under bulk conditions, at a polymerization temperature in a range of ?20-120° C., the conjugated diene is polymerized by using the catalyst system, to produce polyisoprene and polybutadiene having controllable number-average molecular weight, molecular weight distribution of 3.0 or less than, and cis 1,4-content of 95% or more, even 99% or more. The crude rubber and vulcanized rubber of the polyisoprene have high strength, stretching crystallization capability and transparency.

Abstract: A phantom for use in quality control measurement of a fully integrated magnetic resonance/PET scanner is disclosed. The phantom features radiation activity distributed throughout an electrically conductive binder. Suitably, the binder is elastomeric and includes carbon fibers distributed throughout it to set the conductivity of the phantom to a desired level. The phantom is applicable to various multimodality integrated medical imaging systems such as MR/SPECT and MR/CT in addition to MR/PET.

Abstract: A solid fiduciary marker for registering at least two images when imaging the same subject using distinct imaging devices is disclosed. The solid fiduciary marker is visible in at least two of a Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT), Planar gamma camera, X-ray CT, planar X-ray, Magnetic Resonance Imaging (MRI), and optical imager. The marker includes at least two of various doping compounds to be detected by the various imaging systems. The doping compounds include a positron emitting nuclide, a gamma emitting nuclide, a doping compound, metal, and a silicone-based polymer is used in association with an MRI device.

Abstract: An isoprene or butadiene cis 1,4-selective polymerization catalyst system together with its polymerization method is provided. This catalyst system is composed of NCN-imine pincer type rare earth metal complex of formula [2,6-(CH?N—R1)2-4-R2-1-C6H2]LnX2(THF)n and alkylating reagent. In an hydrocarbon solvent or under bulk conditions, at a polymerization temperature in a range of ?20-120° C., the conjugated diene is polymerized by using the catalyst system, to produce polyisoprene and polybutadiene having controllable number-average molecular weight, molecular weight distribution of 3.0 or less than, and cis 1,4-content of 95% or more, even 99% or more. The crude rubber and vulcanized rubber of the polyisoprene have high strength, stretching crystallization capability and transparency.

Abstract: A phantom for use in quality control measurement of a fully integrated magnetic resonance/PET scanner is disclosed. The phantom features radiation activity distributed throughout an electrically conductive binder. Suitably, the binder is elastomeric and includes carbon fibers distributed throughout it to set the conductivity of the phantom to a desired level. The phantom is applicable to various multimodality integrated medical imaging systems such as MR/SPECT and MR/CT in addition to MR/PET.

Abstract: A solid fiduciary marker for registering at least two images when imaging the same subject using distinct imaging devices is disclosed. The solid fiduciary marker is visible in at least two of a Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT), Planar gamma camera, X-ray CT, planar X-ray, Magnetic Resonance Imaging (MRI), and optical imager. The marker includes at least two of various doping compounds to be detected by the various imaging systems. The doping compounds include a positron emitting nuclide, a gamma emitting nuclide, a doping compound, metal, and a silicone-based polymer is used in association with an MRI device.