Patents by Inventor Xinpeng MA
Xinpeng MA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240115741Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.Type: ApplicationFiled: August 14, 2023Publication date: April 11, 2024Applicant: The Board of Regents of The University of Texas SystemInventors: Jinming GAO, Gang HUANG, Tian ZHAO, Xinpeng MA, Yiguang WANG, Yang LI, Baran D. SUMER
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Patent number: 11723990Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.Type: GrantFiled: April 15, 2021Date of Patent: August 15, 2023Assignee: The Board of Regents of The University of Texas SystemInventors: Jinming Gao, Gang Huang, Tian Zhao, Xinpeng Ma, Yiguang Wang, Yang Li, Baran D. Sumer
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Publication number: 20210338840Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.Type: ApplicationFiled: April 15, 2021Publication date: November 4, 2021Applicant: The Board of Regents of the University of Texas SystemInventors: Jinming GAO, Gang HUANG, Tian ZHAO, Xinpeng MA, Yiguang WANG, Yang LI, Baran D. SUMER
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Patent number: 11013818Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.Type: GrantFiled: August 27, 2018Date of Patent: May 25, 2021Assignee: The Board of Regents of the University of Texas SystemInventors: Jinming Gao, Gang Huang, Tian Zhao, Xinpeng Ma, Yiguang Wang, Yang Li, Baran D. Sumer
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Patent number: 10829427Abstract: Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R1, R2, R3, R4, R5, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.Type: GrantFiled: December 16, 2016Date of Patent: November 10, 2020Assignee: The Board of Regents of the University of Texas SystemInventors: Jinming Gao, Yuliang Liu, Qi Wei, Xinpeng Ma, Gang Huang
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Patent number: 10576096Abstract: The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective legality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.Type: GrantFiled: December 6, 2017Date of Patent: March 3, 2020Assignees: The Board of Regents of the University of Texas System, The Board of Trustees of the University of IllinoisInventors: Paul J. Hergenrother, David A. Boothman, Joseph S. Bair, Lifen Cao, Jinming Gao, Xiumei Huang, Xiuquan Luo, Xinpeng Ma, Zachary R. Moore, Elizabeth I. Parkinson
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Patent number: 10272099Abstract: The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.Type: GrantFiled: April 8, 2014Date of Patent: April 30, 2019Assignees: The Board of Regents of the University of Texas System, The Board of Trustees of the University of Illinois.Inventors: Paul J. Hergenrother, David A. Boothman, Joseph S. Bair, Lifen Cao, Jinming Gao, Xiumei Huang, Xiuquan Luo, Xinpeng Ma, Zachary R. Moore, Elizabeth I. Parkinson
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Publication number: 20190071380Abstract: Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R1, R2, R3, R4, R5, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.Type: ApplicationFiled: December 16, 2016Publication date: March 7, 2019Applicant: The Board of Regents of the University of Texas SystemInventors: Jinming GAO, Yuliang LIU, Qi WEI, Xinpeng MA, Gang HUANG
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Publication number: 20180369424Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.Type: ApplicationFiled: August 27, 2018Publication date: December 27, 2018Applicant: The Board of Regents of the University of Texas SystemInventors: Jinming GAO, Gang HUANG, Tian ZHAO, Xinpeng MA, Yiguang WANG, Yang LI, Baran D. SUMER
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Patent number: 10098971Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.Type: GrantFiled: December 5, 2016Date of Patent: October 16, 2018Assignee: The Board of Regents of the University of Texas SystemInventors: Jinming Gao, Gang Huang, Tian Zhao, Xinpeng Ma, Yiguang Wang, Yang Li, Baran D. Sumer
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Publication number: 20180099002Abstract: The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective legality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.Type: ApplicationFiled: December 6, 2017Publication date: April 12, 2018Applicants: The Board of Regents of the University of Texas System, The Board of Trustees of the University of IllinoisInventors: Paul J. HERGENROTHER, David A. BOOTHMAN, Joseph S. BAIR, Lifen CAO, Jinming GAO, Xiumei HUANG, Xiuquan LUO, Xinpeng MA, Zachary R. MOORE, Elizabeth I. PARKINSON
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Publication number: 20170143852Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.Type: ApplicationFiled: December 5, 2016Publication date: May 25, 2017Inventors: Jinming GAO, Gang HUANG, Tian ZHAO, Xinpeng MA, Yiguang WANG, Yang LI, Baran D. SUMER
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Publication number: 20160030457Abstract: The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.Type: ApplicationFiled: April 8, 2014Publication date: February 4, 2016Applicants: The Board of Regents of the University of Texas System, The Board of Trustees of University of IllinoisInventors: Paul J. HERGENROTHER, David A. BOOTHMAN, Joseph S. BAIR, Lifen CAO, Jinming GAO, Xiumei HUANG, Xiuquan LUO, Xinpeng MA, Zachary R. MOORE, Elizabeth I. PARKINSON
