Patents by Inventor Xinping Han

Xinping Han has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND METHODS FOR KRAS MODULATION AND INDICATIONS THEREFOR
    Publication number: 20230081426
    Abstract: Disclosed are compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer, or a deuterated analog thereof, wherein: R1, R2, R3, X, and Z are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.
    Type: Application
    Filed: September 20, 2021
    Publication date: March 16, 2023
    Inventors: Jiazhong Zhang, John Buell, Phuongly Pham, Wayne Spevak, Mark Vander Wal, Xinping Han, Chao Zhang, Zuojun Guo, Jack Walleshauser, Ying Zhang, Steven Rank, Yasuyuki Ogawa, Songyuan Shi
  • UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF
    Publication number: 20210317134
    Abstract: Disclosed herein, inter alia, compounds and methods of use thereof for the modulation of USP7 activity.
    Type: Application
    Filed: March 5, 2020
    Publication date: October 14, 2021
    Inventors: Jacob Bradley Schwarz, John Michael Ketcham, Maureen Kay Reilly, Berenger Biannic, Minna Hue Thanh Bui, Dennis X. Hu, David Juergen Wustrow, Emily Karbarz, Xinping Han, Grant Shibuya, Jack Maung, Maksim Osipov
  • Ubiquitin-specific-processing protease 7 (USP7) modulators and uses thereof
    Patent number: 11084829
    Abstract: Disclosed herein, inter alia, compounds and methods of use thereof for the modulation of USP7 activity.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: August 10, 2021
    Assignee: RAPT THERAPEUTICS, INC.
    Inventors: Berenger Biannic, Xinping Han, Dennis X. Hu, Paul Robert Leger, Jack Maung, Akinori Okano, Jacob Bradley Schwarz, David Juergen Wustrow, Kyle Young, Gene Cutler, Yamini Ohol-Gupta
  • COMPOUNDS AND METHODS FOR CD73 MODULATION AND INDICATIONS THEREFOR
    Publication number: 20210198239
    Abstract: Disclosed are compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer or a deuterated analog thereof, wherein R1, R2, R3, A, L, and G are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.
    Type: Application
    Filed: December 4, 2020
    Publication date: July 1, 2021
    Inventors: Mark Vander Wal, John Buell, Xinping Han, Yongil Jin, Guoxian Wu, Songyuan Shi, Wayne Spevak, Jack Walleshauser, Jiazhong Zhang, Ying Zhang, Zuojun Guo
  • Pyrazolo-pyrimidin-amino-cycloalkyl compounds and their therapeutic uses
    Patent number: 11046699
    Abstract: Disclosed herein are pyrozolo-pyrimidin-amino-cycloalkyl compounds, analogs thereof, pharmaceutical compositions comprising thereof and therapeutic uses therefor.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: June 29, 2021
    Assignee: RAPT THERAPEUTICS, INC.
    Inventors: Minna H. T. Bui, Adrian O. Dukes, Xinping Han, Dennis X. Hu, Jeffrey J. Jackson, Yoo Min Ko, Paul R. Leger, Anqi Ma, Jack Maung, Andrew A. Ng, Akinori Okano, Omar Robles, Grant Shibuya, Hunter P. Shunatona, Jacob B. Schwarz, Anton A. Shakhmin, David J. Wustrow, Mikhail Zibinsky
  • Ubiquitin-specific-processing protease 7 (USP7) modulators and uses thereof
    Patent number: 10722514
    Abstract: Disclosed herein, inter alia, compounds and methods of use thereof for the modulation of USP7 activity.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: July 28, 2020
    Assignee: RAPT THERAPEUTICS, INC.
    Inventors: Berenger Biannic, Xinping Han, Dennis X. Hu, John Michael Ketcham, Paul Robert Leger, Jack Maung, Akinori Okano, Jacob Bradley Schwarz, Grant Shibuya, David Juergen Wustrow, Kyle Young
  • UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF
    Publication number: 20200095260
    Abstract: Disclosed herein, inter alia, compounds and methods of use thereof for the modulation of USP7 activity.
    Type: Application
    Filed: September 20, 2019
    Publication date: March 26, 2020
    Inventors: Berenger Biannic, Xinping Han, Dennis X. Hu, Paul Robert Leger, Jack Maung, Akinori Okano, Jacob Bradley Schwarz, David Juergen Wustrow, Kyle Young, Gene Cutler, Yamini Ohol-Gupta
  • PYRAZOLO-PYRIMIDIN-AMINO-CYCLOALKYL COMPOUNDS AND THEIR THERAPEUTIC USES
    Publication number: 20190375753
    Abstract: Disclosed herein are pyrozolo-pyrimidin-amino-cycloalkyl compounds, analogs thereof, pharmaceutical compositions comprising thereof and therapeutic uses therefor.
    Type: Application
    Filed: June 4, 2019
    Publication date: December 12, 2019
    Inventors: Minna H. T. Bui, Adrian O. Dukes, Xinping Han, Dennis X. Hu, Jeffrey J. Jackson, Yoo Min Ko, Paul R. Leger, Anqi Ma, Jack Maung, Andrew A. Ng, Akinori Okano, Omar Robles, Grant Shibuya, Hunter P. Shunatona, Jacob B. Schwarz, Anton A. Shakhmin, David J. Wustrow, Mikhail Zibinsky
  • UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF
    Publication number: 20190142834
    Abstract: Disclosed herein, inter alia, compounds and methods of use thereof for the modulation of USP7 activity.
    Type: Application
    Filed: November 13, 2018
    Publication date: May 16, 2019
    Inventors: Berenger Biannic, Xinping Han, Dennis X. Hu, John Michael Ketcham, Paul Robert Leger, Jack Maung, Akinori Okano, Jacob Bradley Schwarz, Grant Shibuya, David Juergen Wustrow, Kyle Young
  • Unmanned intelligent mining machine
    Patent number: 9494036
    Abstract: The present invention relates to the field of mining machines, particularly to an unmanned intelligent mining machine. The unmanned intelligent mining machine comprises a cutting part body, a reciprocating telescoping device and a deployable flank cutting device, wherein the reciprocating telescoping device is used to drive a cutting drum to reciprocate back and forth, and the deployable flank cutting device can be deployed toward flanks of the cutting part body and cuts the orebody in the direction of the flanks. When the unmanned intelligent mining machine retreats, the deployable flank cutting device is deployed toward both sides of the cutting part body. After deployed, the deployable flank cutting device forms a certain angle with the longitudinal direction of the cutting part body, and can cut the orebodies on both sides simultaneously, forming a caving face on both sides of the roadway, and increasing the mining amount of unmanned intelligent mining machine.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: November 15, 2016
    Inventor: Xinping Han
  • UNMANNED INTELLIGENT MINING MACHINE
    Publication number: 20150275665
    Abstract: The present invention relates to the field of mining machines, particularly to an unmanned intelligent mining machine. The unmanned intelligent mining machine comprises a cutting part body, a reciprocating telescoping device and a deployable flank cutting device, wherein the reciprocating telescoping device is used to drive a cutting drum to reciprocate back and forth, and the deployable flank cutting device can be deployed toward flanks of the cutting part body and cuts the orebody in the direction of the flanks. When the unmanned intelligent mining machine retreats, the deployable flank cutting device is deployed toward both sides of the cutting part body. After deployed, the deployable flank cutting device forms a certain angle with the longitudinal direction of the cutting part body, and can cut the orebodies on both sides simultaneously, forming a caving face on both sides of the roadway, and increasing the mining amount of unmanned intelligent mining machine.
    Type: Application
    Filed: June 19, 2014
    Publication date: October 1, 2015
    Inventor: Xinping Han