Patents by Inventor Xinying Zhou
Xinying Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11666911Abstract: A sample extraction chip and a biological reaction device are disclosed according to the present disclosure. The sample extraction chip includes a chip body and a sample extraction module provided on the chip body, the sample extraction module includes a sample-loading lysis unit, a liquid release-control unit, an extraction unit, a liquid switch-control unit, a liquid collection unit and a sample collection unit, which are connected through flow channels in a sequence of extraction. The liquid release-control unit is configured to store and release liquid reagents, and the liquid switch-control unit is configured to switch between communication of the liquid collection unit and the extraction unit and communication of the sample collection unit and the extraction unit. The sample collection unit includes a front collection portion and a rear collection portion which are both in communication with the liquid switch-control unit.Type: GrantFiled: December 14, 2020Date of Patent: June 6, 2023Assignee: Capitalbio CorporationInventors: Longtang Zheng, Lei Wang, Liang Bai, Xinying Zhou, Fei Wen, Yanan Wang, Xiang Chen, Tengfei Guo, Baolian Li, Li Ma, Jing Cheng
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Patent number: 11577240Abstract: A liquid storage and controlled-release device and a biological detection chip. The liquid storage and controlled-release device comprises a liquid storage capsule with a liquid storage body which is deformable under a pressure, and a sealing layer for sealing the liquid storage body. A support platform is provided right below the liquid storage capsule and tightly connected with the liquid storage capsule, wherein, a directional release chamber is provided at the middle of the support platform, and the directional release chamber is provided with a guiding chamber for collecting the liquid and a sharp edge for inducing break. Compared with the conventional technology, the opening for liquid release is at the end far away from the rotation center, so that the liquid can be released completely by the centrifugal force, ensuring the quantitative release of stored liquid and reducing the influence on the accuracy of the subsequent detection.Type: GrantFiled: February 3, 2021Date of Patent: February 14, 2023Assignees: Capitalbio Corporation, West China Hospital of Sichuan UniversityInventors: Xinying Zhou, Lei Wang, Liang Bai, Tengfei Guo, Shuo Li, Baolian Li, Bin Zhuang, Xiang Chen, Hongju Guo, Xiaolei Zhao, Wanli Xing, Jing Cheng
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Patent number: 11565255Abstract: A valve system for driving fluid and a method for using the same are provided. The valve system includes a fluid unit far away from the rotation center, a fluid unit close to the rotation center, a fluid transferring unit and a gas path pipeline for communicating the fluid unit close to the rotation center with the fluid unit far away from the rotation center. A rotation radius of a fluid outlet of the fluid unit far away from the rotation center is greater than that of a fluid inlet of the fluid unit close to the rotation center. The fluid outlet of the fluid unit far away from the rotation center is located at an end thereof away from the rotation center, and the fluid inlet of the fluid unit close to the rotation center is located at an end thereof close to the rotation center.Type: GrantFiled: February 5, 2021Date of Patent: January 31, 2023Assignees: Capitalbio Corporation, West China Hospital of Sichuan UniversityInventors: Liang Bai, Tengfei Guo, Lei Wang, Xinying Zhou, Juan Xin, Baolian Li, Li Ma, Libing Dong, Jing Cheng
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Publication number: 20210322979Abstract: A liquid storage and controlled-release device and a biological detection chip. The liquid storage and controlled-release device comprises a liquid storage capsule with a liquid storage body which is deformable under a pressure, and a sealing layer for sealing the liquid storage body. A support platform is provided right below the liquid storage capsule and tightly connected with the liquid storage capsule, wherein, a directional release chamber is provided at the middle of the support platform, and the directional release chamber is provided with a guiding chamber for collecting the liquid and a sharp edge for inducing break. Compared with the conventional technology, the opening for liquid release is at the end far away from the rotation center, so that the liquid can be released completely by the centrifugal force, ensuring the quantitative release of stored liquid and reducing the influence on the accuracy of the subsequent detection.Type: ApplicationFiled: February 3, 2021Publication date: October 21, 2021Inventors: Xinying Zhou, Lei Wang, Liang Bai, Tengfei Guo, Shuo Li, Baolian Li, Bin Zhuang, Xiang Chen, Hongju Guo, Xiaolei Zhao, Wanli Xing, Jing Cheng
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Publication number: 20210322980Abstract: A whole-process biological detection device is provided. The whole-process biological detection device belongs to the technical field of biological detection, and includes at least one reactor, where the reactor includes at least one sample-loading unit, at least one liquid release-control unit, at least one extraction unit, at least one liquid switch-control unit, at least one liquid collection unit, at least one liquid transfer unit, at least one liquid flow-control unit, at least one liquid quantitative dispersion unit and multiple reaction cells. The product of the solution has the characteristics of high integration, no need for additional reagents, simple operation, stable and reliable, etc., thereby achieving the goal of sealing the whole process of biological detection and effectively avoiding cross-contamination between samples and equipment.Type: ApplicationFiled: March 1, 2021Publication date: October 21, 2021Inventors: Lei WANG, Liang BAI, Xiang CHEN, Tengfei GUO, Xinying ZHOU, Jing CHENG, Fei WEN, Yanan WANG, Longtang ZHENG, Peng LIU, Baolian LI, Youchun XU, Bin ZHUANG, Wanli XING
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Publication number: 20210322983Abstract: A valve system for driving fluid and a method for using the same are provided. The valve system includes a fluid unit far away from the rotation center, a fluid unit close to the rotation center, a fluid transferring unit and a gas path pipeline for communicating the fluid unit close to the rotation center with the fluid unit far away from the rotation center. A rotation radius of a fluid outlet of the fluid unit far away from the rotation center is greater than that of a fluid inlet of the fluid unit close to the rotation center. The fluid outlet of the fluid unit far away from the rotation center is located at an end thereof away from the rotation center, and the fluid inlet of the fluid unit close to the rotation center is located at an end thereof close to the rotation center.Type: ApplicationFiled: February 5, 2021Publication date: October 21, 2021Inventors: Liang Bai, Tengfei Guo, Lei Wang, Xinying Zhou, Juan Xin, Baolian Li, Li Ma, Libing Dong, Jing Cheng
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Publication number: 20210322982Abstract: A sample extraction chip and a biological reaction device are disclosed according to the present disclosure. The sample extraction chip includes a chip body and a sample extraction module provided on the chip body, the sample extraction module includes a sample-loading lysis unit, a liquid release-control unit, an extraction unit, a liquid switch-control unit, a liquid collection unit and a sample collection unit, which are connected through flow channels in a sequence of extraction. The liquid release-control unit is configured to store and release liquid reagents, and the liquid switch-control unit is configured to switch between communication of the liquid collection unit and the extraction unit and communication of the sample collection unit and the extraction unit. The sample collection unit includes a front collection portion and a rear collection portion which are both in communication with the liquid switch-control unit.Type: ApplicationFiled: December 14, 2020Publication date: October 21, 2021Inventors: Longtang Zheng, Lei Wang, Liang Bai, Xinying Zhou, Fei Wen, Yanan Wang, Xiang Chen, Tengfei Guo, Baolian Li, Li Ma, Jing Cheng
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Patent number: 10300483Abstract: A multi-index detection microfluidic chip is provided. A bottom plate (1) and a cover plate (2) that matches the bottom plate (1) and seals it are provided in the microfluidic chip. The center of the microfluidic chip has a through-hole (3). The bottom plate (1) has one or more wave-shaped main channel(s) (4), one end of each of the main channel (4) connected to a sample injection hole (9) on the bottom plate (1), and the other end connected to an exhaust hole (10) on the bottom plate (1). The valley on the main channel (1) is distal to the through-hole (3), and the peak is proximal to the through-hole (3). Each valley of the main channel (1) is connected to a reaction chamber (6) by a linking channel (5). The linking channel (5) comprises one or more buffering chambers (7). The microfluidic chip can be used in detection by fluorescence, turbidity, color, detection equipment, and/or direct observation by the naked eyes. The detection is real-time as the reaction occurs or after the reaction.Type: GrantFiled: March 6, 2015Date of Patent: May 28, 2019Assignee: Capitalbio Technology CorporationInventors: Lei Wang, Guohao Zhang, Xinying Zhou, Juan Xin, Yao Zhang, Mingxian Lin, Guoliang Huang, Can Wang, Wanli Xing, Jing Cheng
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Patent number: 10099218Abstract: In one aspect, disclosed herein are methods for packaging biochips, including microfluidic chips. The method can comprise bonding a substrate and a cover slide, packaging the bonded chip, creating a vacuum in the package, and applying a pressure on the packaged chip. The method is particularly useful for minimizing bubble formation during low-cost and mass production of microfluidic chips.Type: GrantFiled: November 18, 2016Date of Patent: October 16, 2018Assignee: CAPITALBIO CORPORATIONInventors: Lei Wang, Xinying Zhou, Li Ma, Juan Xin, Mingxian Lin, Jinhai Feng
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Publication number: 20170144150Abstract: In one aspect, disclosed herein are methods for packaging biochips, including microfluidic chips. The method can comprise bonding a substrate and a cover slide, packaging the bonded chip, creating a vacuum in the package, and applying a pressure on the packaged chip. The method is particularly useful for minimizing bubble formation during low-cost and mass production of microfluidic chips.Type: ApplicationFiled: November 18, 2016Publication date: May 25, 2017Applicant: CapitalBio CorporationInventors: Lei WANG, Xinying ZHOU, Li MA, Juan XIN, Mingxian LIN, Jinhai FENG
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Publication number: 20170014818Abstract: A multi-index detection microfluidic chip is provided. A bottom plate (1) and a cover plate (2) that matches the bottom plate (1) and seals it are provided in the microfluidic chip. The center of the microfluidic chip has a through-hole (3). The bottom plate (1) has one or more wave-shaped main channel (s) (4), one end of each of the main channel (4) connected to a sample injection hole (9) on the bottom plate (1), and the other end connected to an exhaust hole (10) on the bottom plate (1). The valley on the main channel (1) is distal to the through-hole (3), and the peak is proximal to the through-hole (3). Each valley of the main channel (1) is connected to a reaction chamber (6) by a linking channel (5). The linking channel (5) comprises one or more buffering chambers (7). The microfluidic chip can be used in detection by fluorescence, turbidity, color, detection equipment, and/or direct observation by the naked eyes. The detection is real-time as the reaction occurs or after the reaction.Type: ApplicationFiled: March 6, 2015Publication date: January 19, 2017Applicants: CAPITALBIO CORPORATION, TSINGHUA UNIVERSITYInventors: Lei WANG, Guohao ZHANG, Xinying ZHOU, Juan XIN, Yao ZHANG, Mingxian LIN, Guoliang HUANG, Can WANG, Wanli XING, Jing CHENG
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Publication number: 20050130042Abstract: This invention discloses materials for positive electrodes of secondary batteries and their methods of fabrication. Said materials comprise of granules of an active material for positive electrodes coated with an oxide layer. The active material is one or more of the following: oxides of lithium cobalt, oxides of lithium nickel cobalt, oxides of lithium nickel cobalt manganese, oxides of lithium manganese, LiCoO2, LiNi1-xCoxO2, LiNi1/3Co1/3Mn1/3O2, and LiMn2O4. The non-oxygen component in the oxide layer is one or more of the following: aluminum, magnesium, zinc, calcium, barium, strontium, lanthanum, cerium, vanadium, titanium, tin, silicon, boron, Al, Mg, Zn, Ca, Ba, Sr, La, Ce, V, Ti, Sn, Si, and B. Said non-oxygen component of the granules is between 0.01 wt. % to 10 wt. % of said granules of active material.Type: ApplicationFiled: December 10, 2004Publication date: June 16, 2005Inventors: Huiquan Liu, Xinying Zhou