Patents by Inventor Xinzhen Yang

Xinzhen Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human cytomegalovirus gB polypeptide
    Patent number: 11629172
    Abstract: The present invention relates to polypeptides and cytomegalovirus (CMV) antigens that include at least one introduced amino acid mutation relative to the amino acid sequence of the wild-type HCMV glycoprotein B (gB). In some embodiments, the polypeptide is stabilized in a conformation alternative to the gB postfusion conformation. Also disclosed are compositions including the polypeptides and uses thereof.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: April 18, 2023
    Assignee: Pfizer Inc.
    Inventors: Philip Ralph Dormitzer, Ye Che, Xiaoyuan Sherry Chi, Seungil Han, Kyle Paul Heim, Thomas Richard Jones, Yuhang Liu, Xiayang Qiu, Xinzhen Yang, Xiaojie Yao, Matthew Curtis Griffor, Jennifer Anne Nicki
  • HUMAN CYTOMEGALOVIRUS GB POLYPEPTIDE
    Publication number: 20200247853
    Abstract: The present invention relates to polypeptides and cytomegalovirus (CMV) antigens that include at least one introduced amino acid mutation relative to the amino acid sequence of the wild-type HCMV glycoprotein B (gB). In some embodiments, the polypeptide is stabilized in a conformation alternative to the gB postfusion conformation. Also disclosed are compositions including the polypeptides and uses thereof.
    Type: Application
    Filed: December 19, 2019
    Publication date: August 6, 2020
    Inventors: Philip Ralph Dormitzer, Ye Che, Xiaoyuan Sherry Chi, Seungil Han, Kyle Paul Heim, Thomas Richard Jones, Yuhang Liu, Xiayang Qiu, Xinzhen Yang, Xiaojie Yao, Matthew Curtis Griffor, Jennifer Anne Nicki
  • Human cytomegalovirus gB polypeptide
    Patent number: 10611800
    Abstract: The present invention relates to a polypeptide that includes at least one mutation in the fusion loop 1 region and/or in the fusion loop 2 region and/or in the furin-like cleavage site of a human cytomegalovirus gB polypeptide. In one embodiment, the polypeptide undergoes a structural conformation change in response to pH change.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: April 7, 2020
    Assignee: Pfizer Inc.
    Inventors: Xinzhen Yang, Xiaoyuan Sherry Chi
  • HUMAN CYTOMEGALOVIRUS GB POLYPEPTIDE
    Publication number: 20190127422
    Abstract: The present invention relates to a polypeptide that includes at least one mutation in the fusion loop 1 region and/or in the fusion loop 2 region and/or in the furin-like cleavage site of a human cytomegalovirus gB polypeptide. In one embodiment, the polypeptide undergoes a structural conformation change in response to pH change.
    Type: Application
    Filed: March 9, 2017
    Publication date: May 2, 2019
    Inventors: Xinzhen Yang, Xiaoyuan Sherry Chi
  • Stabilized soluble glycoprotein trimers
    Patent number: 7429653
    Abstract: The present application is directed to stabilized HIV envelope glycoprotein trimers. The trimers are stabilized by introducing trimeric motifs, preferably the GCN4 coiled coil or the fibritin trimeric domain, at certain sites, for example in the gp41 ectodomain. These stabilized trimers or DNA molecules encoding such trimers can be used to generate an immunogenic reaction. The trimers can also be used in assays to screen for molecules that interact with them—and to identify molecules that interact with specific sites.
    Type: Grant
    Filed: May 11, 2005
    Date of Patent: September 30, 2008
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Joseph G. Sodroski, Richard Wyatt, Xinzhen Yang, Michael Farzan, Peter D. Kwong
  • Stabilized soluble glycoprotein trimers
    Publication number: 20050220817
    Abstract: The present application is directed to stabilized HIV envelope glycoprotein trimers. The trimers are stabilized by introducing trimeric motifs, preferably the GCN4 coiled coil or the fibritin trimeric domain, at certain sites, for example in the gp41 ectodomain. These stabilized trimers or DNA molecules encoding such trimers can be used to generate an immunogenic reaction. The trimers can also be used in assays to screen for molecules that interact with them—and to identify molecules that interact with specific sites.
    Type: Application
    Filed: May 11, 2005
    Publication date: October 6, 2005
    Applicants: Dana-Farber Cancer Institute, Inc., The Trustees of Columbia University
    Inventors: Joseph Sodroski, Richard Wyatt, Xinzhen Yang, Michael Farzan, Peter Kwong
  • Stabilized soluble glycoprotein trimers
    Patent number: 6911205
    Abstract: The present application is directed to stabilized HIV envelope glycoprotein trimers. The trimers are stabilized by introducing trimeric motifs, preferably the GCN4 coiled coil or the fibritin trimeric domain at certain sites, for example in the gp41 ectodomain. These stabilized trimers or DNA molecules encoding such trimers can be used to generate an immunogenic reaction. The trimers can also be used in assays to screen for molecules that interact with them—and to identify molecules that interact with specific sites.
    Type: Grant
    Filed: March 18, 2002
    Date of Patent: June 28, 2005
    Assignees: Dana-Farber Cancer Institute, Inc., The Trustees of Columbia University
    Inventors: Joseph G. Sodroski, Richard Wyatt, Xinzhen Yang, Michael Farzan, Peter D. Kwong
  • STABILIZED SOLUBLE GLYCOPROTEIN TRIMERS
    Publication number: 20050106177
    Abstract: The present application is directed to stabilized HIV envelope glycoprotein trimers. The trimers are stabilized by introducing trimeric motifs, preferably the GCN4 coiled coil or the fibritin trimeric domain, at certain sites, for example in the gp41 ectodomain. These stabilized trimers or DNA molecules encoding such trimers can be used to generate an immunogenic reaction. The trimers can also be used in assays to screen for molecules that interact with them—and to identify molecules that interact with specific sites.
    Type: Application
    Filed: March 18, 2002
    Publication date: May 19, 2005
    Inventors: Joseph Sodroski, Richard Wyatt, Xinzhen Yang, Michael Farzan, Peter Kwong