Patents by Inventor Xiu-Min Li

Xiu-Min Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230414560
    Abstract: A pharmaceutical composition for the treatment of eczema is disclosed. Also disclosed are methods of treating eczema in a subject by administering a pharmaceutical composition.
    Type: Application
    Filed: May 24, 2023
    Publication date: December 28, 2023
    Inventors: Xiu-Min Li, Nan Yang, Zhenzhen Wang
  • Patent number: 11351157
    Abstract: The disclosure provides methods of treating immunological conditions, e.g., allergy, by administration of berberine nanoparticles.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: June 7, 2022
    Assignees: Icahn School of Medicine at Mount Sinai, Sean N. Parker Foundation
    Inventors: Xiu-Min Li, Changda Liu, Kamal Srivatava, Haiqiong Yu, Sean N Parker
  • Publication number: 20200276172
    Abstract: The disclosure provides methods of treating immunological conditions, e.g., allergy, by administration of berberine nanoparticles.
    Type: Application
    Filed: October 16, 2017
    Publication date: September 3, 2020
    Inventors: Xiu-Min Li, Changda Liu, Kamal Srivatava, Haiqiong Yu, Sean N Parker
  • Patent number: 10500169
    Abstract: The present invention relates to compounds and formulations derived from traditional Chinese medicine for use for the treatment and/or mediation of food allergies, in particular peanut allergies in humans by altering the activity and/or production of IgE.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: December 10, 2019
    Assignees: Sean N. Parker Foundation
    Inventors: Xiu-Min Li, Nan Yang, Chaoyi Mao, Ying Song, Sean N. Parker
  • Patent number: 10406191
    Abstract: The present invention relates to extracts of Sophora Flavescens, and compounds isolated therefrom for use in modulating airway smooth muscle contractility. Methods of creating enriched extracts of Sophora Flavescens are disclosed, as are specific compounds isolated therefrom. Methods for the treatment of disorders involving airway smooth muscle, such as asthma, using the compounds and extracts described herein are also disclosed.
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: September 10, 2019
    Inventors: Xiu-Min Li, Hugh A. Sampson, Nan Yang, Kamal Srivastava, Charles Emala
  • Patent number: 10028985
    Abstract: The present invention relates to formulations made up from extracts from Ganoderma lucidum, rhizome of Coptis chinensis, Radix astragali, Nelumbo nucifera Gaertn, Chaenomeles speciosa, and Fructus Aurantii. Pursuant to the invention, the formulations are used to treat obesity and the biological sequelae of obesity including cholesterol levels and glucose levels. While not limited to any particular mechanism of action the formulations may assert their effects by altering gene expression, in particular, the expression of PPAR?, FABP4, CPT1, UCP2, and AMPK.
    Type: Grant
    Filed: December 3, 2014
    Date of Patent: July 24, 2018
    Inventors: Xiu-Min Li, Danna Chung, Nan Yang
  • Publication number: 20180044384
    Abstract: The present disclosure provides compositions comprising recombinant bacterial spores. The present disclosure is also directed to vaccine based compositions, which include recombinant bacterial spores that express CTB and a peanut protein(s) on their surfaces. This disclosure also provides methods for administering these compositions as a treatment or prevention of peanut allergy.
    Type: Application
    Filed: February 17, 2017
    Publication date: February 15, 2018
    Inventors: Xiu-Min LI, Zhenwen Zhou, Zhigang LIU, Ying SONG
  • Publication number: 20160296573
    Abstract: The present invention relates to formulations made up from extracts from Ganoderma lucidum, rhizome of Coptis chinensis, Radix astragali, Nelumbo nucifera Gaertn, Chaenomeles speciosa, and Fructus Aurantii. Pursuant to the invention, the formulations are used to treat obesity and the biological sequelae of obesity including cholesterol levels and glucose levels. While not limited to any particular mechanism of action the formulations may assert their effects by altering gene expression, in particular, the expression of PPAR?, FABP4, CPT1, UCP2, and AMPK.
    Type: Application
    Filed: December 3, 2014
    Publication date: October 13, 2016
    Inventors: Xiu-min LI, Danna CHUNG, Nan YANG
  • Publication number: 20160175291
    Abstract: The present invention relates to compounds and formulations derived from traditional Chinese medicine for use for the treatment and/or mediation of food allergies, in particular peanut allergies in humans by altering the activity and/or production of IgE.
    Type: Application
    Filed: September 17, 2015
    Publication date: June 23, 2016
    Inventors: Xiu-Min Li, Nan Yang, Chaoyi Mao, Ying Song
  • Publication number: 20150359834
    Abstract: The present invention relates to extracts of Sophora Flavascens, and compounds isolated therefrom for use in modulating airway smooth muscle contractility. Methods of creating enriched extracts of Sophora Flavascens are disclosed, as are specific compounds isolated therefrom. Methods for the treatment of disorders involving airway smooth muscle, such as asthma, using the compounds and extracts described herein are also disclosed.
    Type: Application
    Filed: January 21, 2014
    Publication date: December 17, 2015
    Inventors: Xiu-Min LI, Sampson HUGH, Nan YANG, Kamal SRIVASTAVA, Charles EMALA
  • Publication number: 20120295868
    Abstract: The invention relates to a glucan having a beta-(1,3)-backbone with one or more beta-(1,3)-side chains linked thereto for use in the treatment of asthma and related diseases of abnormal pulmonary function in an animal. Also described is a method of treating asthma and related diseases of abnormal pulmonary function in an animal comprising administering to said animal an effective amount of a glucan having a beta-(1,3)-backbone with one or more beta-(1,3)-side chains linked thereto.
    Type: Application
    Filed: July 30, 2012
    Publication date: November 22, 2012
    Applicants: Mount Sinai School of Medicine of New York University, Biotec Pharmacon ASA
    Inventors: Rolf SELJELID, Xiu-Min LI
  • Publication number: 20100322923
    Abstract: The invention relates to a glucan having a beta-(1,3)-backbone with one or more beta-(1,3)-side chains linked thereto for use in the treatment of asthma and related diseases of abnormal pulmonary function in an animal. Also described is a method of treating asthma and related diseases of abnormal pulmonary function in an animal comprising administering to said animal an effective amount of a glucan having a beta-(1,3)-backbone with one or more beta-(1,3)-side chains linked thereto.
    Type: Application
    Filed: February 21, 2008
    Publication date: December 23, 2010
    Applicant: BIOTEC PHARMACON ASA
    Inventors: Rolf Seljelid, Xiu-Min Li
  • Patent number: 7854935
    Abstract: The present invention provides herbal formulas, and compositions thereof, that can treat or reduce the severity, intensity, or duration of asthma and asthma-related symptoms. The compositions may optionally include one or more adjuvants, cytokines, encapsulating materials, or pharmaceutically acceptable carriers or excipients, and may be administered prior to, during, or after the development of asthmatic symptoms in a patient in need thereof.
    Type: Grant
    Filed: March 14, 2005
    Date of Patent: December 21, 2010
    Assignee: Herbal Spring, LLC
    Inventors: Xiu-Min Li, Hugh A. Sampson, Ming-Chun Weng
  • Patent number: 7820175
    Abstract: The present invention provides herbal formulas, and compositions thereof, that can treat or reduce the severity, intensity, or duration of food allergy and food allergy related symptoms. The compositions may optionally include one or more adjuvants, cytokines, encapsulating materials, or pharmaceutically acceptable carriers or excipients, and may be administered prior to, during, or after the development of food allergy-related symptoms in a patient in need thereof.
    Type: Grant
    Filed: March 14, 2005
    Date of Patent: October 26, 2010
    Assignee: Herbal Spring, LLC
    Inventors: Xiu-Min Li, Hugh A. Sampson
  • Publication number: 20080317878
    Abstract: The present invention provides herbal formulas, and compositions thereof, that can treat or reduce the severity, intensity, or duration of food allergy and food allergyrelated symptoms. The compositions may optionally include one or more adjuvants, cytokines, encapsulating materials, or pharmaceutically acceptable carriers or excipients, and may be administered prior to, during, or after the development of food allergy-related symptoms in a patient in need thereof.
    Type: Application
    Filed: March 14, 2005
    Publication date: December 25, 2008
    Inventors: Xiu-Min Li, Hugh A. Sampson
  • Publication number: 20080213298
    Abstract: The present invention provides herbal formulas, and compositions thereof, that can treat or reduce the severity, intensity, or duration of asthma and asthma-related symptoms. The compositions may optionally include one or more adjuvants, cytokines, encapsulating materials, or pharmaceutically acceptable carriers or excipients, and may be administered prior to, during, or after the development of asthmatic symptoms in a patient in need thereof.
    Type: Application
    Filed: March 14, 2005
    Publication date: September 4, 2008
    Inventors: Xiu-Min Li, Hugh A. Sampson, Ming-Chun Weng
  • Patent number: 6630176
    Abstract: The present invention provides herbal compositions that can prevent or reduce the severity, intensity, or duration of allergic and/or asthmatic symptoms and/or can prevent or delay the development of an allergic or asthmatic response to an antigen. The compositions may optionally include one or more adjuvants, cytokines, encapsulating materials, or pharmaceutical carriers or excipients, and may be administered prior to, during, or after the development of allergic or asthmatic symptoms in sensitized individuals. Alternatively or additionally, the compositions may be administered prior to sensitization to a particular antigen; preferably substantially concurrently with exposure to the antigen.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: October 7, 2003
    Assignee: Mount Sinai School of Medicine of New York University
    Inventors: Xiu-Min Li, Hugh A. Sampson
  • Publication number: 20030157126
    Abstract: The present invention provides herbal compositions that can prevent or reduce the severity, intensity, or duration of allergic and/or asthmatic symptoms and/or can prevent or delay the development of an allergic or asthmatic response to an antigen. The compositions may optionally include one or more adjuvants, cytokines, encapsulating materials, or pharmaceutical carriers or excipients, and may be administered prior to, during, or after the development of allergic or asthmatic symptoms in sensitized individuals. Alternatively or additionally, the compositions may be administered prior to sensitization to a particular antigen; preferably substantially concurrently with exposure to the antigen.
    Type: Application
    Filed: March 7, 2001
    Publication date: August 21, 2003
    Inventors: Xiu-Min Li, Hugh A. Sampson
  • Patent number: 6121247
    Abstract: Administration of an expression gene construct for IFN-.gamma. to an affected organ is an effective means of reversing antigen-induced inflammation. Suitable allergic diseases for treatment include atopic asthma, rhinitis, and dermatitis.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: September 19, 2000
    Assignee: The Johns Hopkins University
    Inventors: Shau-Ku Huang, Marsha Wills-Karp, Xiu-Min Li, Andrea Keane-Myers