Abstract: Described are niclosamide analogue compounds, pharmaceutical compositions thereof, and method of using the corner pounds and compositions for treating a disease associated with dysregulation of the Wnt/Frizzled signaling pathway, such as cancer, fatty liver, antibiotic resistance, and viral infection. The disclosed compounds and compositions may also be used for modulating mitochondrial function and for treating certain non-cancer diseases and/or diorders, such as diabetes, fibrotic disease, primary sclerosing cholangitis.

Abstract: The present disclosure relates to the field of vehicle technology and provides an energy recovery control method, a system, and a vehicle. The method is applied in a vehicle, and the vehicle comprises a drive motor and a battery electrically connected to the drive motor; a first energy recovery torque curve with respect to the drive motor is pre-configured in the vehicle, and the first energy recovery torque curve is used to indicate a correspondence relationship between vehicle speed and energy recovery torque of the drive motor. The present disclosure performs reduction on a first energy recovery torque curve by means of utilizing a reduction ratio, allowing energy recovery in accordance with a relatively low torque strength when a usable charge power of the battery is unable to satisfy a preset power requirement corresponding to the first energy recovery torque curve.

Abstract: Disclosed is a secondary battery including a positive electrode, a negative electrode and a separator interposed between the positive electrode and the negative electrode, wherein the positive electrode includes a positive electrode current collector, and a positive electrode active material layer disposed on the positive electrode current collector, the positive electrode active material layer including a positive electrode active material and a binder. The negative electrode includes a negative electrode current collector and a negative electrode active material layer disposed on the negative electrode current collector, the negative electrode active material layer including a negative electrode active material and a binder.

Abstract: A positive electrode active material, and a positive electrode and a lithium secondary battery including the same are disclosed herein. In some embodiments, a positive electrode active material includes a lithium composite transition metal oxide containing nickel, cobalt, and manganese and having a nickel content for 60 mol % or more, based on metals (M) excluding lithium, and is in the form of single particles having an average particle diameter (D50) of 1 to 10 ?m, wherein a 100-nm region extending from the surface toward the center of a single particle has crystal structures of a Fd3M and a Fm3m space group, and a phase ratio is 0.2 to 0.7, which is a ratio of a first portion of a maximum straight length of the 100-nm region occupied by the crystal structure of the Fd3M space group to a second portion occupied by the crystal structure of the Fm3m space group.

Abstract: A positive electrode active material, method of making the same, and positive electrode and lithium secondary battery include the same are disclosed herein. In some embodiments, a positive electrode active material in a form of single particles, includes a lithium transition metal oxide having nickel (Ni) in an amount greater than 50 mol % based on a total number of moles of transition metals excluding lithium, wherein a single particle has a region of 50 nm or less from a surface of the single particle along a center direction, and wherein a structure belonging to space group FD3-M and a structure belonging to space group Fm3m are formed in the region, and wherein a generation rate of fine powder having an average particle diameter (D50) of 1 ?m or less is in a range of 5% to 30% when the positive electrode active material is rolled at 650 kgf/cm2.

Abstract: A spinel-structured lithium manganese-based positive electrode active material includes a lithium manganese oxide represented by Formula 1, and a coating layer which is disposed on a surface of the lithium manganese oxide and includes at least one coating element selected from the group consisting of aluminum, titanium, tungsten, boron, fluorine, phosphorus, magnesium, nickel, cobalt, iron, chromium, vanadium, copper, calcium, zinc, zirconium, niobium, molybdenum, strontium, antimony, bismuth, silicon, and sulfur, and a positive electrode and a lithium secondary battery which include the positive electrode active material, Li1+aMn2?bM1bO4?cAc??[Formula 1] wherein, in Formula 1, M1 is at least one metallic element including lithium (Li), A is at least one element selected from the group consisting of fluorine, chlorine, bromine, iodine, astatine, and sulfur, 0?a?0.2, 0<b?0.5, and 0?c?0.1.

Abstract: The present invention relates to a positive electrode material for a secondary battery, the positive electrode material including a first positive electrode active material and a second positive electrode active material, the first positive electrode active material and the second positive electrode active material being single particle types and lithium composite transition metal oxides including nickel, cobalt, and manganese and having a nickel content accounting for 60 mol % or more of total metals except for lithium, wherein the first positive electrode active material has a mean particle diameter (D50) of 3 ?m or less and a molar ratio (Li/M) of lithium to the metals (M) except for lithium of 1.10 to 1.20, and the second positive electrode active material has a mean particle diameter (D50) of greater than 3 ?m and a molar ratio (Li/M) of lithium to the metals (M) except for lithium of 1.00 to 1.13.

Abstract: Disclosed are compounds of Formula A, or a salt thereof: Wherein “A1”, R1, R2, R3, R6, and R7 are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating cough, itch and neuropathic pain disorders using the same.

Abstract: A method of preparing a positive electrode active material for a secondary battery, is disclosed herein. In some embodiments, a method includes mixing a positive electrode active material precursor, a lithium source material, a first firing additive, a second firing additive, and a third firing additive a to form a mixture, wherein the positive electrode active material precursor contains nickel, cobalt, and manganese and has a nickel content of 60 mol % or more relative to a total molar amount of metals in the positive electrode active material precursor, and performing primary firing of the mixture to form a lithium transition metal oxide, wherein the first firing additive is a lithium-containing compound, the second firing additive is a carbonate ion-containing compound, and the third firing additive is a boron-containing compound.

Abstract: The present disclosure relates to a positive electrode material including a spinel-structured lithium manganese-based first positive electrode active material and a lithium nickel-manganese-cobalt-based second positive electrode active material, wherein the first positive electrode active material includes a lithium manganese oxide represented by Formula 1 and a coating layer which is disposed on a surface of the lithium manganese oxide, the second positive electrode active material is represented by Formula 2, and an average particle diameter of the second positive electrode active material is greater than an average particle diameter of the first positive electrode active material, and a positive electrode and a lithium secondary battery which include the positive electrode material: Li1+aMn2?bM1bO4?cAc??[Formula 1] Li1+x[NiyCozMnwM2v]O2?pBp??[Formula 2]

Abstract: A method of preparing an octahedral-structured lithium manganese-based positive electrode active material includes mixing a manganese raw material, a raw material including doping element M1, wherein the doping element M1 is at least one element selected from the group consisting of Mg, Al, Li, Zn, B, W, Ni, Co, Fe, Cr, V, Ru, Cu, Cd, Ag, Y, Sc, Ga, In, As, Sb, Pt, Au, and Si, and a lithium raw material and sintering the mixture in an oxygen atmosphere to prepare a lithium manganese oxide having an octahedral structure and doped with the doping element M1, wherein the sintering includes performing first sintering at 400° C. to 700° C. for 3 hours to 10 hours and performing second sintering at 700° C. to 900° C. for 10 hours to 20 hours. Also provided is an octahedral-structured lithium manganese-based positive electrode active material prepared by the above preparation method.

Abstract: In one arrangement, the present disclosure relates to a positive electrode active material including a nickel-cobalt-manganese-based lithium transition metal oxide which contains nickel in an amount of 60 mol % or more based on a total number of moles of metals excluding lithium, wherein the nickel-cobalt-manganese-based lithium transition metal oxide is doped with doping element M1 (where the doping element M1 is a metallic element including Al) and doping element M2 (where the doping element M2 is at least one metallic element selected from the group consisting of Mg, La, Ti, Zn, B, W, Ni, Co, Fe, Cr, V, Ru, Cu, Cd, Ag, Y, Sc, Ga, In, As, Sb, Pt, Au, and Si), where the doping element M1 can be in an amount of 100 ppm to 10,000 ppm, and the doping element M1 and the doping element M2 are included in a weight ratio of 50:50 to 99:1.

Abstract: The present disclosure relates to a positive electrode active material for a secondary battery, the positive electrode active material being a lithium composite transition metal oxide particle including nickel (Ni) and cobalt (Co) and including at least one of manganese (Mn) and aluminum (Al), wherein the lithium composite transition metal oxide particle includes 60 mol % or greater of the nickel (Ni) in all metals excluding lithium, a doping element is doped on the lithium composite transition metal oxide particle, and the particle intensity of the lithium composite transition metal oxide particle is 210 MPa to 290 MPa.

Abstract: A spinel-structured lithium manganese-based positive electrode active material includes a lithium manganese oxide represented by Formula 1, and a coating layer which is disposed on a surface of the lithium manganese oxide and includes at least one coating element selected from the group consisting of aluminum, titanium, tungsten, boron, fluorine, phosphorus, magnesium, nickel, cobalt, iron, chromium, vanadium, copper, calcium, zinc, zirconium, niobium, molybdenum, strontium, antimony, bismuth, silicon, and sulfur, and a positive electrode and a lithium secondary battery which include the positive electrode active material, Li1+aMn2?bM1bO4?cAc ??[Formula 1] wherein, in Formula 1, M1 is at least one metallic element including lithium (Li), A is at least one element selected from the group consisting of fluorine, chlorine, bromine, iodine, astatine, and sulfur, 0?a?0.2, 0<b?0.5, and 0?c?0.1.

Abstract: The present disclosure relates to a positive electrode material including a spinel-structured lithium manganese-based first positive electrode active material and a lithium nickel-manganese-cobalt-based second positive electrode active material, wherein the first positive electrode active material includes a lithium manganese oxide represented by Formula 1 and a coating layer which is disposed on a surface of the lithium manganese oxide, the second positive electrode active material is represented by Formula 2, and an average particle diameter of the second positive electrode active material is greater than an average particle diameter of the first positive electrode active material, and a positive electrode and a lithium secondary battery which include the positive electrode material: Li1+aMn2-bM1bO4-cAc??[Formula 1] Li1+x[NiyCozMnwM2v]O2-pBp??[Formula 2]

Abstract: In a device for producing quantitative-diameter spray droplets of pesticide, a driving motor is controlled by a control center, the driving motor drives a lead screw, the lead screw drives a sliding device to achieve a designated accurate position on a guide track, and a piston moves slowly along with the sliding device to extrude chemicals in a droplet generator quantitatively, the chemicals extruded by the piston through the motion in a droplet cavity forms small single droplets through a guide pipe, the droplets with specific particle size are further generated by precisely controlling the extrusion amount of the chemicals, so that the device can be widely used for studies about diffusion of the droplets evaporation property of the single droplets and the like tested by water-sensitive paper, as well as tests of the properties of the pesticide, and further has broad application prospects.

Abstract: Disclosed are compounds of Formula A-a, or a salt thereof: Where “B1” and “R1” through “R5” are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-a or their salts, and methods of treating neuropathic pain disorders using the same.

Abstract: Disclosed are compounds of Formula A-a, or a salt thereof: Where “B1” and “R1” through “R5” are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-a or their salts, and methods of treating neuropathic pain disorders using the same.