Abstract: The present invention generally relates to Fab-based antibody-like binding proteins comprising three antigen-binding domains that specifically bind one or more target proteins, wherein the antibody domain interfaces are engineered so that they readily self-assemble. The disclosure also provides methods for making trispecific binding proteins and uses of such binding proteins.

Abstract: Multispecific binding proteins that bind a first antigen and a second antigen and methods of purifying multispecific binding proteins.

Abstract: The present invention discloses a method and system for a wind stress coefficient expression by comprehensively considering impacts of an average wind speed, a fetch and a water depth, and relates to the field of wind-wave-current numerical simulation studies. Based on a wind-wave-current coupling interaction mechanism in lakes, oceans and other waters, two dimensionless numbers that can represent a wind-wave-current interaction strength: a fetch Froude number and a fetch Reynolds number, are constructed, a form of a wind stress coefficient expression with an undetermined coefficient is established, and then the undetermined coefficient is obtained by using a nonlinear regression method with reference to experimental and measured data to obtain a final wind stress coefficient expression.

Abstract: The present invention relates to anti-human CD200R agonist antibodies, and uses thereof for treating diseases such as atopic dermatitis, chronic spontaneous urticaria, allergy, asthma, scleroderma, IBD, SLE, MS, RA, GvHD, or psoriasis.

Abstract: The present invention relates to anti-human CD200R agonist antibodies, and uses thereof for treating diseases such as atopic dermatitis, chronic spontaneous urticaria, allergy, asthma, scleroderma, IBD, SLE, MS, RA, GvHD, or psoriasis.

Abstract: The present invention relates to anti-human CD200R agonist antibodies, and uses thereof for treating diseases such as atopic dermatitis, chronic spontaneous urticaria, allergy, asthma, scleroderma, IBD, SLE, MS, RA, GvHD, or psoriasis.

Abstract: IgG bispecific antibodies are provided that bind human Calcitonin Gene Related Peptide (CGRP) and human Interleukin-23 (IL-23) and are characterized as having high affinity and strong simultaneous neutralizing properties to both human CGRP and human IL-23. The bispecific antibodies of the invention are useful for treating various autoimmune diseases including Inflammatory Bowel Disease, such as Crohn's Disease (CD) and Ulcerative Colitis (UC), and other autoimmune diseases such as psoriatic Arthritis (PsA), ankylosing spondylitis (AS) and atopic dermatitis (AtD). The bispecific antibodies of the invention are useful for treating pain associated with the aforementioned diseases.

Abstract: The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light chain variable (VH/VL) domain and the heavy chain-light chain constant (CH1/CL) domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.

Abstract: The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light chain variable (VH/VL) domain and the heavy chain-light chain constant (CH/CL) domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.

Abstract: The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light chain variable (VH/VL) domain and the heavy chain-light chain constant (CH1/CL] domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.

Abstract: IgG bispecific antibodies are provided that bind human Calcitonin Gene Related Peptide (CGRP) and human Interleukin-23 (IL-23) and are characterized as having high affinity and strong simultaneous neutralizing properties to both human CGRP and human IL-23. The bispecific antibodies of the invention are useful for treating various autoimmune diseases including Inflammatory Bowel Disease, such as Crohn's Disease (CD) and Ulcerative Colitis (UC), and other autoimmune diseases such as psoriatic Arthritis (PsA), ankylosing spondylitis (AS) and atopic dermatitis (AtD). The bispecific antibodies of the invention are useful for treating pain associated with the aforementioned diseases.

Abstract: The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain light-chain variable (VH/VL) domain and the heavy chain-light chain constant (CH1/CL) domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.

Abstract: The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light chain variable (VH/VL) domain and the heavy chain-light chain constant (CH1/CL] domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.

Abstract: Disclosed is a transmission method compatible with higher order modulation and lower order modulation, and an apparatus. A base station stores a first higher order modulation mapping table supporting the higher order modulation and a first lower order modulation mapping table supporting the lower order modulation; the base station receives capability level information sent by user equipment; the base station determines, according to the capability level information sent by the user equipment, a first modulation mapping table used to communicate with the user equipment; the base station determines a modulation and coding scheme index according to the modulation mapping table, where the modulation and coding scheme index is used by the user equipment to determine a modulation and coding scheme; and the modulation and coding scheme index is sent to the user equipment.

Abstract: Disclosed is a transmission method compatible with higher order modulation and lower order modulation, and an apparatus. A base station stores a first higher order modulation mapping table supporting the higher order modulation and a first lower order modulation mapping table supporting the lower order modulation; the base station receives capability level information sent by user equipment; the base station determines, according to the capability level information sent by the user equipment, a first modulation mapping table used to communicate with the user equipment; the base station determines a modulation and coding scheme index according to the modulation mapping table, where the modulation and coding scheme index is used by the user equipment to determine a modulation and coding scheme; and the modulation and coding scheme index is sent to the user equipment.

Abstract: Disclosed is a transmission method compatible with higher order modulation and lower order modulation, and an apparatus. A base station stores a first higher order modulation mapping table supporting the higher order modulation and a first lower order modulation mapping table supporting the lower order modulation; the base station receives capability level information sent by user equipment; the base station determines, according to the capability level information sent by the user equipment, a first modulation mapping table used to communicate with the user equipment; the base station determines a modulation and coding scheme index according to the modulation mapping table, where the modulation and coding scheme index is used by the user equipment to determine a modulation and coding scheme; and the modulation and coding scheme index is sent to the user equipment.

Abstract: The present invention discloses a method for scheduling user equipment on a full-duplex cellular network, including: determining a pairing set for each piece of user equipment in a cell, where a pairing parameter of the piece of user equipment and any piece of user equipment that is in the pairing set of the piece of user equipment meets a preset threshold; and selecting, when a piece of user equipment is scheduled to perform data transmission, another piece of user equipment from a pairing set of the piece of user equipment to perform data transmission in an opposite direction. Embodiments of the present invention further provide a corresponding apparatus. According to the technical solution of the present invention, existing spectrum resources can be utilized more thoroughly and spectrum utilization efficiency of wireless access can be improved.

Abstract: Disclosed is a transmission method compatible with higher order modulation and lower order modulation, and an apparatus. A base station stores a first higher order modulation mapping table supporting the higher order modulation and a first lower order modulation mapping table supporting the lower order modulation; the base station receives capability level information sent by user equipment; the base station determines, according to the capability level information sent by the user equipment, a first modulation mapping table used to communicate with the user equipment; the base station determines a modulation and coding scheme index according to the modulation mapping table, where the modulation and coding scheme index is used by the user equipment to determine a modulation and coding scheme; and the modulation and coding scheme index is sent to the user equipment.

Abstract: The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light chain variable (VH/VL) domain and the heavy chain-light chain constant (CH1/CL] domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.

Abstract: The present invention discloses a method for scheduling user equipment on a full-duplex cellular network, including: determining a pairing set for each piece of user equipment in a cell, where a pairing parameter of the piece of user equipment and any piece of user equipment that is in the pairing set of the piece of user equipment meets a preset threshold; and selecting, when a piece of user equipment is scheduled to perform data transmission, another piece of user equipment from a pairing set of the piece of user equipment to perform data transmission in an opposite direction. Embodiments of the present invention further provide a corresponding apparatus. According to the technical solution of the present invention, existing spectrum resources can be utilized more thoroughly and spectrum utilization efficiency of wireless access can be improved.