Patents by Inventor Xiuli Zuang

Xiuli Zuang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cisplatin complex and preparation method thereof
    Patent number: 9629923
    Abstract: A CDDP complex is formed by complexation of CDDP and a polymer having a structure of Formula (I). The CDDP complex has good biocompatibility and is degradable. A side chain of the polymer is grafted with polyethylene glycol, which gives the CDDP complex good dissolvability. When dissolved in an aqueous medium, the CDDP is protected by a hydrophilic polyethylene glycol chain segment and a hydrophobic amino acid chain segment, which can effectively avoid a sudden release of the CDDP due to the influence of the blood circulation system after intravenous injection, thus improving the stability of the CDDP complex. A carboxyl group contained in the CDDP complex has pH value sensitivity and tends to be deprotonated in a low pH environment, which is advantageous for promoting the release of a drug, and improving the efficiency of the drug.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: April 25, 2017
    Assignee: Changchun Institute of Applied Chemistry, Chinese Academy of Science
    Inventors: Zhaohui Tang, Haiyang Yu, Wantong Song, Mingqiang Li, Xiuli Zuang, Xuesi Chen
  • CISPLATIN COMPLEX AND PREPARATION METHOD THEREOF
    Publication number: 20150231273
    Abstract: A CDDP complex is formed by complexation of CDDP and a polymer having a structure of Formula (I). The CDDP complex has good biocompatibility and is degradable. A side chain of the polymer is grafted with polyethylene glycol, which gives the CDDP complex good dissolvability. When dissolved in an aqueous medium, the CDDP is protected by a hydrophilic polyethylene glycol chain segment and a hydrophobic amino acid chain segment, which can effectively avoid a sudden release of the CDDP due to the influence of the blood circulation system after intravenous injection, thus improving the stability of the CDDP complex. A carboxyl group contained in the CDDP complex has pH value sensitivity and tends to be deprotonated in a low pH environment, which is advantageous for promoting the release of a drug, and improving the efficiency of the drug.
    Type: Application
    Filed: March 26, 2013
    Publication date: August 20, 2015
    Applicant: CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCE
    Inventors: Zhaohui Tang, Haiyang Yu, Wantong Song, Mingqiang Li, Xiuli Zuang, Xuesi Chen