Abstract: A new medical technique using follicular T cells is provided. The present disclosure is based on the finding of public TfhTCR which is specific to disease factors common to various patients, and provides a method for producing follicular T cells specific to a disease, including a step of identifying a disease-related factor or a part thereof having the ability to induce a follicular T cell reactive with the disease-related factor, a step of inducing the follicular T cell specific to the disease, by using the disease-related factor or a part thereof, and a step of obtaining the follicular T cell specific to the disease.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for controlling an agent. One of the methods includes sampling one or more index variables from a continuous space of possible index variables in accordance with a probability distribution over the continuous space; for each index variable: processing the index variable using a hypermodel, in accordance with values of a plurality of parameters of the hypermodel, to generate an output that specifies values of a plurality of parameters of an environment model; and generating an action selection output using the environment model in accordance with the values of the plurality of parameters of the environment model that are specified by the hypermodel output for the index variable; and selecting the action to be performed by the agent at the time step using the one or more action selection outputs for the one or more index variables.