Abstract: According to the present disclosure, the use of a nanoliposome in the manufacture of a medicament for the prophylaxis and/or treatment of anterior segment ocular diseases is provided. The nanoliposome comprises a plurality of unsaturated and/or saturated lipids forming at least one lipid bilayer encapsulating a hydrophobic drug comprising tacrolimus, wherein the hydrophobic drug and the plurality of unsaturated and/or saturated lipids have a weight ratio of up to 0.2. The present disclosure also provides for such a nanoliposome and a method of preventing and/or treating anterior segment ocular diseases based on the nanoliposomes.

Abstract: According to the present disclosure, the use of a nanoliposome in the manufacture of a medicament for the prophylaxis and/or treatment of anterior segment ocular diseases is provided. The nanoliposome comprises a plurality of unsaturated and/or saturated lipids forming at least one lipid bilayer encapsulating a hydrophobic drug comprising tacrolimus, wherein the hydrophobic drug and the plurality of unsaturated and/or saturated lipids have a weight ratio of up to 0.2. The present disclosure also provides for such a nanoliposome and a method of preventing and/or treating anterior segment ocular diseases based on the nanoliposomes.

Abstract: In various embodiments, a wearable non-invasive apparatus for enhancing lower limb venous return of a subject may be provided. The apparatus may include a monitoring device configured to determine a venous state of a subject such as a photoplethysmography (PPG) sensor. The apparatus may also include a neuromuscular electrical stimulation (NMES) device configured to generate an electrical stimulus in response to the determinedvenous state and concurrently stimulate the triceps surae and the deep posterior calf muscle of the subject with the generated electrical stimulus to enhance lower limb venous return. In an alternative embodiment, electrical stimulation can be at the tibial nerve of the subject to retrograde target the triceps surae and the deep posterior calf muscle of the subject.

Abstract: In various embodiments, a wearable non-invasive apparatus for enhancing lower limb venous return of a subject may be provided. The apparatus may include a monitoring device configured to determine a venous state of a subject such as a photoplethysmography (PPG) sensor. The apparatus may also include a neuromuscular electrical stimulation (NMES) device configured to generate an electrical stimulus in response to the determinedvenous state and concurrently stimulate the triceps surae and the deep posterior calf muscle of the subject with the generated electrical stimulus to enhance lower limb venous return. In an alternative embodiment, electrical stimulation can be at the tibial nerve of the subject to retrograde target the triceps surae and the deep posterior calf muscle of the subject.

Abstract: According to the present disclosure, the use of a nanoliposome in the manufacture of a medicament for the prophylaxis and/or treatment of anterior segment ocular diseases is provided. The nanoliposome comprises a plurality of unsaturated and/or saturated lipids forming at least one lipid bilayer encapsulating a hydrophobic drug comprising tacrolimus, wherein the hydrophobic drug and the plurality of unsaturated and/or saturated lipids have a weight ratio of up to 0.2. The present disclosure also provides for such a nanoliposome and a method of preventing and/or treating anterior segment ocular diseases based on the nanoliposomes.