Patents by Inventor Xuanxian PENG

Xuanxian PENG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of succinic acid in increasing sensitivity of bacteria to antibiotics
    Patent number: 11752120
    Abstract: The present invention belongs to the technical field of medicine, and specifically relates to use of succinic acid in increasing sensitivity of bacteria to antibiotics. The present invention found that the succinic acid can increase proton motive force of bacteria, thereby increasing the number of antibiotics entering the bacteria, and eventually killing the bacteria. Therefore, the succinic acid can increase the sensitivity of bacteria to antibiotics, thereby overcoming the problem of bacterial drug resistance. Combining succinic acid with antibiotics can significantly improve the bactericidal effect of the antibiotics, which has better effects and higher safety and operability compared with only using antibiotics as antibacterial drugs at present.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: September 12, 2023
    Assignee: SUN YAT-SEN UNIVERSITY
    Inventors: Hui Li, Bo Peng, Xuanxian Peng
  • APPLICATION OF COMPOUND AMINO ACIDS IN PREPARATION OF MEDICAMENT FOR IMPROVING SENSITIVITY OF BACTERIA TO ANTIBIOTICS
    Publication number: 20220409563
    Abstract: The invention belongs to the technical field of biomedicament, and more specifically relates to an application of compound amino acids in preparation of a medicament for improving sensitivity of bacteria to antibiotics. Experiments have shown that a combination of compound amino acids and antibiotics can improve the sensitivity of bacteria to antibiotics, promote an entry of antibiotics into bacterial cells, significantly increase an intracellular antibiotic content, and improve a bactericidal effect of antibiotics, thereby reducing a survival rate of bacteria, and treating diseases caused by bacterial infection.
    Type: Application
    Filed: July 20, 2021
    Publication date: December 29, 2022
    Applicant: SUN YAT-SEN UNIVERSITY
    Inventors: Hui LI, Bo PENG, Xuanxian PENG, Shishi LAI
  • USE OF SUCCINIC ACID IN INCREASING SENSITIVITY OF BACTERIA TO ANTIBIOTICS
    Publication number: 20210128506
    Abstract: The present invention belongs to the technical field of medicine, and specifically relates to use of succinic acid in increasing sensitivity of bacteria to antibiotics. The present invention found that the succinic acid can increase proton motive force of bacteria, thereby increasing the number of antibiotics entering the bacteria, and eventually killing the bacteria. Therefore, the succinic acid can increase the sensitivity of bacteria to antibiotics, thereby overcoming the problem of bacterial drug resistance. Combining succinic acid with antibiotics can significantly improve the bactericidal effect of the antibiotics, which has better effects and higher safety and operability compared with only using antibiotics as antibacterial drugs at present.
    Type: Application
    Filed: June 12, 2018
    Publication date: May 6, 2021
    Applicant: SUN YAT-SEN UNIVERSITY
    Inventors: Hui LI, Bo PENG, Xuanxian PENG
  • Method of treating an individual having a microbial infection
    Patent number: 10792263
    Abstract: Glycine, threonine, and serine can enhance the sensitivity of bacteria to serum, plasma, or whole blood, and therefore can be used as molecules to improve the bactericidal effect of the serum, the plasma, or the whole blood.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: October 6, 2020
    Assignee: Sun Yat-Sen University
    Inventors: Xuanxian Peng, Hui Li, Zhixue Cheng, Chang Guo
  • Small molecule substance for improving sensitivity of bacteria to antibiotics
    Patent number: 9962351
    Abstract: Disclosed is a new function of a small molecule metabolite glutamine. The small molecule can improve sensitivity of bacteria including antibiotic-resistant bacteria to antibiotics. Also disclosed is an application of glutamine in combination with glucose in improving sensitivity of bacteria to antibiotics.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: May 8, 2018
    Assignee: SUN YAT-SEN UNIVERSITY
    Inventors: Xuanxian Peng, Hui Li, Xianliang Zhao
  • AMINO ACID IMPROVING SENSITIVITY OF BATCTERIA TO SERUM
    Publication number: 20150359770
    Abstract: Glycine, threonine, and serine can enhance the sensitivity of bacteria to serum, plasma, or whole blood, and therefore can be used as molecules to improve the bactericidal effect of the serum, the plasma, or the whole blood.
    Type: Application
    Filed: January 14, 2013
    Publication date: December 17, 2015
    Applicant: Sun Yat-Sen University
    Inventors: Xuanxian Peng, Hui Li, Zhixue Cheng, Chang Guo
  • SMALL MOLECULE SUBSTANCE FOR IMPROVING SENSITIVITY OF BACTERIA TO ANTIBIOTICS
    Publication number: 20150297547
    Abstract: Disclosed is a new function of a small molecule metabolite glutamine. The small molecule can improve sensitivity of bacteria including antibiotic-resistant bacteria to antibiotics. Also disclosed is an application of glutamine in combination with glucose in improving sensitivity of bacteria to antibiotics.
    Type: Application
    Filed: December 4, 2012
    Publication date: October 22, 2015
    Inventors: Xuanxian PENG, Hui LI, Xianliang ZHAO