Abstract: The present application relates to a novel benzoazepine compound, comprising a pharmaceutically acceptable salt thereof. The present application also provides a pharmaceutical composition comprising the compound and a pharmaceutically acceptable salt thereof. The present application relates to use of the compound and the composition in the prevention or treatment of diseases related to arginine vasopressin V1a receptor, arginine vasopressin V1b receptor, arginine vasopressin V2 receptor, sympathetic nervous system or renin-angiotensin-aldosterone system. The present application also provides a method for preventing and/or treating arginine vasopressin-related diseases.

Abstract: The invention discloses a biosensor chip and a COVID-19 test kit. The COVID-19 test kit includes a biosensor chip, rolling circle amplification (RCA) primers, RCA padlock probes, and ssDNA conjugated nanoparticles (i.e., ssDNA-NPs probe). In this invention, the surface of the biosensor chip is modified with functional polymers; subsequently, detection ligands are grafted on the modified sensor chip surface to capture the targets. The developed biosensor chip achieves rapid and ultra-sensitive on-site detection of COVID-19 infections. In addition, a signal amplification method is employed using RCA products hybridized ssDNA-NPs probes (i.e., RCA-NPs) complex to amplify the detection signal and to improve the detection sensitivity.

Abstract: A tower segment, a tower, a segmentation method, and a wind turbine. The tower segment includes an annular body having two opposite end faces along the axial direction thereof, the annular body being formed by assembling a plurality of tower pieces; and a connecting member configured for connecting the two adjacent tower pieces, the connecting member including a first connecting piece and a second connecting piece that can be detachably connected to each other, wherein the side of the first connecting piece away from the second connecting piece is fixedly connected to an inner annular surface and an outer annular surface of one of the two adjacent tower pieces, and the side of the second connecting piece away from the first connecting piece is fixedly connected to the inner annular surface and the outer annular surface of the other of the two adjacent tower pieces.

Abstract: A tower portion, a tower, and a wind turbine generator assembly are provided. The tower portion includes: a main tower portion, and a longitudinal flange pair. The main tower portion is divided into at least two sections by means a longitudinal seam formed in a longitudinal direction thereof. The longitudinal flange pair is provided in the longitudinal seam along the longitudinal direction of the main tower portion. The longitudinal flange pair protrudes from an inner surface and an outer surface of the main tower portion in a radial direction thereof, and is welded to a corresponding section of the main tower portion. The tower portion reduces welding difficulty, reduces heat produced during the welding process, and improves the quality of the weld. The application further discloses a method for manufacturing the tower portion.

Abstract: A tower segment (100), a tower, a segmentation method, and a wind turbine.

Abstract: A micro-fluidic chip and its modification method and application in detection of food bacteria quality, includes the following steps: changing a functional group —CH3 on the internal surface of micro-fluidic channel of micro-fluidic chip to a functional group —OH through modification; Supplying amino silane reagent to the micro-fluidic channel; supplying dendritic polymer as modified by —COOH to internal surface of the micro-fluidic channel after drying; grafting primer of aminated aptamer RCA on terminus 5? and hybrid from its padlock probe on dendrimer on internal surface of the micro-fluidic channel; wherein, the padlock probe is the complementary sequence of the aptamer of the target pathogenic bacteria to be tested; after that, supplying RCA reaction reagent to the micro-fluidic channel to make aptamer RCA generate long-chain aptamer in series. The present invention adopts two RCA reactions of varied functions in combination, and uses dendritic polymer to modify internal surface of the chip.

Abstract: A tower portion, a tower, and a wind turbine generator assembly are provided. The tower portion includes: a main tower portion, and a longitudinal flange pair. The main tower portion is divided into at least two sections by means a longitudinal seam formed in a longitudinal direction thereof. The longitudinal flange pair is provided in the longitudinal seam along the longitudinal direction of the main tower portion. The longitudinal flange pair protrudes from an inner surface and an outer surface of the main tower portion in a radial direction thereof, and is welded to a corresponding section of the main tower portion. The tower portion reduces welding difficulty, reduces heat produced during the welding process, and improves the quality of the weld. The application further discloses a method for manufacturing the tower portion.

Abstract: The present invention relates to the field of pharmaceutical chemistry, and specifically relates to a fused heterocyclic compound derivative and an application thereof. The fused heterocyclic compound derivative has the structure of general formula (I), and can be used to treat neuropsychiatric diseases.

Abstract: The present invention discloses a micro-fluidic chip and its modification method and application in detection of the quantity of food bacteria, comprising the following steps: changing functional group —CH3 on the internal surface of micro-fluidic channel of micro-fluidic chip to functional group —OH through modification; Supplying amino silane reagent to the micro-fluidic channel; supplying dendritic polymer as modified by —COOH to internal surface of the micro-fluidic channel after drying; grafting primer of aminated aptamer RCA on terminal 5? and hybrid from its padlock probe on dendrimer on internal surface of the micro-fluidic channel; wherein, the padlock probe is the complementary sequence of the aptamer of the target pathogenic bacteria to be tested; after that, supplying RCA reaction reagent to the micro-fluidic channel to make aptamer RCA generate long-chain aptamer in series.

Abstract: The present invention relates to the field of pharmaceutical chemistry, and specifically relates to a fused heterocyclic compound derivative and an application thereof. The fused heterocyclic compound derivative has the structure of general formula (I), and can be used to treat neuropsychiatric diseases.

Abstract: The subject matter described herein relates to face alignment via shape regression. A method, computer storage medium, and system are provided. In one embodiment, the method comprises receiving an image including a face; and performing shape regression to estimate a facial shape in the image. For each stage in the shape regression, a local feature is extracted from a local region around each facial landmark in the image independently; and a joint projection is performed based on local features of multiple facial landmarks to predict a facial shape increment. Then, a facial shape of a current stage is generated based on the predicted facial shape increment and a facial shape of a previous stage.

Abstract: The subject matter described herein relates to face alignment via shape regression. A method, computer storage medium, and system are provided. In one embodiment, the method comprises receiving an image including a face; and performing shape regression to estimate a facial shape in the image. For each stage in the shape regression, a local feature is extracted from a local region around each facial landmark in the image independently; and a joint projection is performed based on local features of multiple facial landmarks to predict a facial shape increment. Then, a facial shape of a current stage is generated based on the predicted facial shape increment and a facial shape of a previous stage.

Abstract: A prebake equipment for drying a substrate (105) and an air discharge method, the prebake equipment comprising: a bottom plate (105), a periphery frame (101) and an upper cover plate, the bottom plate (105) and the upper cover plate being spaced from each other, the periphery frame (101) being provided between the bottom plate (105) and the upper cover plate such that the bottom plate (105), the periphery frame (101) and the upper cover plate define a cavity, wherein discharge holes are provided at the periphery frame (101) and a filler (104) for filtering moisture and dust in the air stream is provided between the bottom plate (105) and the periphery frame (101).

Abstract: This disclosure describes a system for jointly modeling images for use in performing facial recognition. A facial recognition system may jointly model a first image and a second image using a face prior to generate a joint distribution. Conditional joint probabilities are determined based on the joint distribution. A log likelihood ratio of the first image and the second image are calculated based on the conditional joint probabilities and the subject of the first image and the second image are verified as the same person or as different people based on results of the log likelihood ratio.

Abstract: A two-level boosted regression function is learned using shape-indexed image features and correlation-based feature selection. The regression function is learned by explicitly minimizing the alignment errors over the training data. Image features are indexed based on a previous shape estimate, and features are selected based on correlation to a random projection. The learned regression function enforces non-parametric shape constraint.

Abstract: A prebake equipment for drying a substrate (105) and an air discharge method, the prebake equipment comprising: a bottom plate (105), a periphery frame (101) and an upper cover plate, the bottom plate (105) and the upper cover plate being spaced from each other, the periphery frame (101) being provided between the bottom plate (105) and the upper cover plate such that the bottom plate (105), the periphery frame (101) and the upper cover plate define a cavity, wherein discharge holes are provided at the periphery frame (101) and a filler (104) for filtering moisture and dust in the air stream is provided between the bottom plate (105) and the periphery frame (101).