Abstract: Provided herein are inhibitors of AKT1, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the AKT1 inhibitory compounds for the treatment of disease.

Abstract: Provided herein are inhibitors of AKT1, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the AKT1 inhibitory compounds for the treatment of disease.

Abstract: The present invention relates to the technical field of medicines, and in particular to a hydroxytyrosol nicotinamide eutectic crystal, a preparation method therefor and a composition thereof. In the hydroxytyrosol nicotinamide eutectic crystal of the present invention, a molar ratio of hydroxytyrosol to nicotinamide is 1:1, and cell parameters are as follows: a=9.4999, b=11.8285, c=11.4439, ?=90°, ?=96.628°, and ?=90°. The hydroxytyrosol nicotinamide eutectic crystal of the present invention is high in melting point, does not absorb moisture and is good in stability, and the application convenience of the hydroxytyrosol is greatly improved. The composition directly prepared by means of a grinding method has the advantages of high yield and low cost, and is suitable for large-scale application.

Abstract: A stem screening and conditioning device includes a roller, a thermal insulation cover, a spiral feeding device, a compressed-air cleaning device, a steam tube, a discharge hole, and a waste hole. A stem screening and conditioning method for the stem screening and conditioning device is also provided. The present disclosure realizes the complete separation of normal-size and undersized stems under the premise of full moisture absorption, thereby improving the refinement and homogenization level of stem conditioning.

Abstract: The present invention relates to macrocyclic compounds of any one of Formula (I), or a pharmaceutically acceptable form thereof, pharmaceutical compositions comprising the same, methods of preparing the same, and methods of treating cancer dependent on a farnesylated protein, using the same.

Abstract: A stem screening and conditioning device includes a roller, a thermal insulation cover, a spiral feeding device, a compressed-air cleaning device, a steam tube, a discharge hole, and a waste hole. A stem screening and conditioning method for the stem screening and conditioning device is also provided. The present disclosure realizes the complete separation of normal-size and undersized stems under the premise of full moisture absorption, thereby improving the refinement and homogenization level of stem conditioning.

Abstract: An equatorial mount for providing a telescope with a balanced weight distribution is described. The equatorial mount includes a base, a declination base, and a device support. The declination base is rotatable about a right ascension axis relative to the base. The device support is rotatable about a declination axis relative to the declination base. The declination axis intersects orthogonally with the right ascension axis and the declination axis intersects a midsection of the declination base. The declination base includes a counterweight assembly extending along a counterweight axis, the counterweight axis being spaced away from the declination axis along the right ascension axis.

Abstract: A mount comprises: a bracket assembly for holding an image-capture device; a drive shaft rotatably coupled to a stationary wheel for rotation of the drive shaft relative to the stationary wheel about a drive shaft axis; a support member coupled to the drive shaft to rotate about the drive shaft axis therewith, the support member extending radially away from the drive shaft axis; a rotational wheel rotatably coupled to the support member for rotation of the rotational wheel relative to the support member about a rotational wheel axis radially spaced apart from, and parallel to, the drive shaft axis, and coupleable to the bracket assembly such that rotation of the rotational wheel about the rotational wheel axis causes corresponding rotation of the bracket assembly about the rotational wheel axis; and a belt entrained around the stationary wheel and the rotational wheel.

Abstract: An equatorial mount having a base, a right ascension base, a right ascension shaft, a declination base, a declination shaft, and a mount-rotation mechanism, the declination base rotatable about a right ascension axis relative to the right ascension base, and the declination shaft rotatable about a declination axis relative to the declination axis, wherein the mount-rotation mechanism is engageable and disenagageable from one or the other of the right ascension shaft and the declination shaft, to apply torque between the declination base and that shaft when engaged and to permit relative rotation of the shaft and the declination base when disengaged.

Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.

Abstract: The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.

Abstract: Terminal pin device are described herein. The Terminal pin device of the invention comprises a cam box, a cutting mechanism, a material clamping mechanism, a pin inserting mechanism and a cam driving mechanism. The cutting mechanism, the material clamping mechanism, the pin inserting mechanism and the cam driving mechanism are connected with the cam box, and the cam driving mechanism drives the cutting mechanism, the material clamping mechanism and the pin inserting mechanism to operate, so as to realize the integrated terminal cutting, the terminal material clamping and the terminal rotation and terminal pin inserting actions.

Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.

Abstract: An equatorial mount having a base, a right ascension base, a right ascension shaft, a declination base, a declination shaft, and a mount-rotation mechanism, the declination base rotatable about a right ascension axis relative to the right ascension base, and the declination shaft rotatable about a declination axis relative to the declination axis, wherein the mount-rotation mechanism is engageable and disenagageable from one or the other of the right ascension shaft and the declination shaft, to apply torque between the declination base and that shaft when engaged and to permit relative rotation of the shaft and the declination base when disengaged.

Abstract: An equatorial mount for providing a telescope with a balanced weight distribution is described. The equatorial mount comprises a base, a declination base, and a device support. The declination base is rotatable about a right ascension axis relative to the base. The device support is rotatable about a declination axis relative to the declination base. The declination axis intersects orthogonally with the right ascension axis and the declination axis intersects a midsection of the declination base. The declination base comprises a counterweight assembly extending along a counterweight axis, the counterweight axis being spaced away from the declination axis along the right ascension axis.

Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.

Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.

Abstract: Embodiments of apparatus, systems and methods facilitate deployment of distributed computing applications on hybrid public-private infrastructures by facilitating secure access to selected services running on private infrastructures by distributed computing applications running on public cloud infrastructures. In some embodiments, a secure tunnel may be established between proxy processes on the public and private infrastructures and communication between the distributed computing application and the selected services may occur through the proxy processes over the secure tunnel.