Abstract: The present disclosure provides a testis-targeted lycopene (LYC)/ZIF-90 nanocomposite and a preparation method and use thereof, belonging to the technical field of targeted drugs. In the present disclosure, a ZIF-90 metal-organic framework (MOF) material is combined with LYC through aldol condensation; when entering areas of inflammatory response and oxidative stress response, ZIF-90 may disintegrate and collapse in a slightly-acidic environment, releasing the LYC, thereby avoiding easy oxidation of the LYC and improving a bioavailability of the LYC; in addition, the disintegrated and collapsed ZIF-90 may also be utilized by organisms, thus greatly reducing a damage to the organisms. Moreover, the LYC/ZIF-90 nanocomposite is further loaded with follicle-stimulating hormone (FSH).

Abstract: A method of adjusting airflow through a plurality of cooling holes by depositing a thermal barrier coating on an exterior surface and/or an interior surface of the component by a physical vapor deposition process. The cooling holes are not masked. Thus, a portion of the thermal barrier coating partially obstructs airflow through the cooling holes and reduces airflow through the cooling holes. A predetermined pressure drop is developed across the cooling holes and airflow through the cooling holes is measured. The measured airflow is compared to a preselected range of desired cooling hole airflows and the steps of depositing the thermal barrier coating, developing the predetermined pressure drop, calculating airflow and comparing the measured airflow to the preselected range are repeated until the measured airflow is within the preselected range of desired cooling hole airflows.