Abstract: Provided is a GABAA receptor agonist phenol derivative that has a novel structure and better efficacy, can effectively reduce side effects, and is safer for clinical use. Specifically disclosed are a compound as represented by the following formula (I), a stereoisomer and pharmaceutically acceptable salt thereof, a pharmaceutical composition containing same, and an application of the compound or composition of the present invention in the central nervous field, thereby providing more and better choices for medicaments for inducing and/or maintaining anesthesia in animal or human bodies, facilitating sedation and hypnosis, and treating and/or preventing anxiety, nausea, vomiting, migraine, convulsion, epilepsy, neurodegenerative diseases, and central nervous system-related diseases.

Abstract: Disclosed herein are compositions and methods to treat skin with a peracid-based benefit agent. The peracid benefit agent can be used for a benefit such as the prevention or treatment of acne, skin whitening, skin bleaching, skin conditioning, reducing the appearance of skin wrinkles, skin rejuvenation, reducing dermal adhesions, and preventing, reducing or eliminating body odors or any combination thereof. The peracid may be enzymatically generated from a carboxylic acid ester substrate using an enzyme having perhydrolytic activity (perhydrolase) in the presence of a source of peroxygen. A fusion protein comprising the perhydrolase coupled to a skin-binding domain, either directly or through an optional linker, may be used to target the perhydrolytic activity to the skin surface.

Abstract: Compositions and methods comprising the use of stabilized peptide-particulate benefit agent adducts are provided having a multi-block peptide component and a particulate benefit agent, where the multi-block peptide comprises the general structure A1-(S1)p-(X1-Y)n—(X2)m-(S2)q-A2 or A1-(S1)p-(X1)m-(Y—X2)p-(S2)q-A2; wherein, A1 and A2 are body surface-binding domains; S1 and S2 are optional peptide spacers; X1 and X2 are charged amino acid blocks; Y is a hydrophobic amino acid block comprising 3 to 10 contiguous hydrophobic amino acids; m is an integer ranging from 0 to 10; p and q are integers independently ranging from 0 to 3; and n is an integer ranging from 1 to 50. The stable adduct dispersion can be used to durably apply a particulate benefit agent to a body surface.

Abstract: Disclosed herein are compositions and methods for delivering substrates for a depilatory product using an enzymatically-generated peracid. More specifically, a pH stabilized two component system is provided comprising (a) a first aqueous composition comprising hydrogen peroxide and at least one carboxylic acid ester substrate; wherein the pH of the first aqueous composition is 4.0 or less and (b) a second aqueous component comprising an enzyme catalyst having perhydrolytic activity and a buffer, wherein the pH of the second aqueous composition is at least 5.0; wherein the first and second aqueous compositions remain separated until use. The perhydrolytic enzyme catalyst may be in the form of a fusion protein comprising a perhydrolytic enzyme coupled through an optional peptide linker to a peptidic component having affinity for hair.

Abstract: Disclosed herein are compositions and methods for delivering substrates for a depilatory product using an enzymatically generated peracid. More specifically, a two component system is provided comprising (a) a first non-aqueous composition comprising a solid source of peroxygen, an ester substrate, and an optional organic cosolvent and (b) an aqueous component having a pH of at least 4 comprising an enzyme catalyst having perhydrolytic activity and a buffer. The perhydrolytic enzyme catalyst may be in the form of a fusion protein comprising a perhydrolytic enzyme coupled through an optional peptide linker to a peptidic component having affinity for hair.

Abstract: Disclosed herein are compositions and methods to treat hair with a peracid-based benefit agent. The peracid benefit agent can be used for hair bleaching, hair weakening, hair removal, hair waiving, hair straightening or any combination thereof. The peracid may be enzymatically generated from a carboxylic acid ester substrate using an enzyme having perhydrolytic activity (perhydrolase) in the presence of a source of peroxygen. A fusion protein comprising the perhydrolase coupled to a hair-binding domain, either directly or through an optional linker, may be used to target the perhydrolytic activity to the hair surface.

Abstract: Disclosed is an auto-diluting and rinsing apparatus, comprising: a concentrated detergent container for holding concentrated detergent to be diluted; a diluter container for holding diluter, which is used to dilute the concentrated detergent; and a diluted detergent container for holding diluted detergent for rinsing, which are formed by mixing the concentrated detergent and the diluter; wherein the concentrated detergent container and the diluter container are communicated with a high pressure gas source, respectively, and the apparatus further comprising: a gas path controller, configured to control the diluted detergent container to be communicated with a low pressure gas source via a first gas path during a dilution process; and to be communicated with a high pressure gas source during a rinsing process.

Abstract: Disclosed is an auto-diluting and rinsing apparatus, comprising: a concentrated detergent container for holding concentrated detergent to be diluted; a diluter container for holding diluter, which is used to dilute the concentrated detergent; and a diluted detergent container for holding diluted detergent for rinsing, which are formed by mixing the concentrated detergent and the diluter; wherein the concentrated detergent container and the diluter container are communicated with a high pressure gas source, respectively, and the apparatus further comprising: a gas path controller, configured to control the diluted detergent container to be communicated with a low pressure gas source via a first gas path during a dilution process; and to be communicated with a high pressure gas source during a rinsing process.

Abstract: Microparticle-based analytical methods, systems and applications are provided. Specifically, the use of resonant light scattering as an analytical method for determining either or both a particle's identity and the presence and optionally, the concentration of one or more particular target analytes is described. Applications of these microparticle-based methods in biological and chemical assays are also disclosed.

Abstract: In one embodiment of the invention, an error-correcting receiver includes an input buffer for storing received codewords, a first error correction syndrome circuit coupled to receive a first codeword and produce an output word, and a second error correction syndrome circuit coupled to receive a second codeword and produce an output word. An error-trapping-and-decoding circuit alternately receives the output words of the first and second error correction syndrome circuits. An error correction circuit coupled to the error-trapping-and-decoding circuit and the input buffer is adapted to provide corrected codewords.

Abstract: Microparticle-based analytical methods, systems and applications are provided. Specifically, the use of resonant resonant light scattering as an analytical method for determining either or both a particle's identity and the presence and optionally, the concentration of one or more particular target analytes is described. Applications of these microparticle-based methods in biological and chemical assays are also disclosed.

Abstract: Microparticle-based analytical methods, systems and applications are provided. Specifically, the use of resonant resonant light scattering as an analytical method for determining either or both a particle's identity and the presence and optionally, the concentration of one or more particular target analytes is described. Applications of these microparticle-based methods in biological and chemical assays are also disclosed.

Abstract: Microparticle-based analytical methods, systems and applications are provided. Specifically, the use of resonant resonant light scattering as an analytical method for determining either or both a particle's identity and the presence and optionally, the concentration of one or more particular target analytes is described. Applications of these microparticle-based methods in biological and chemical assays are also disclosed.

Abstract: Microparticle-based analytical methods, systems and applications are provided. Specifically, the use of resonant resonant light scattering as an analytical method for determining either or both a particle's identity and the presence and optionally, the concentration of one or more particular target analytes is described. Applications of these microparticle-based methods in biological and chemical assays are also disclosed.

Abstract: Microparticle-based analytical methods, systems and applications are provided. Specifically, the use of resonant resonant light scattering as an analytical method for determining either or both a particle's identity and the presence and optionally, the concentration of one or more particular target analytes is described. Applications of these microparticle-based methods in biological and chemical assays are also disclosed.

Abstract: Microparticle-based analytical methods, systems and applications are provided. Specifically, the use of resonant resonant light scattering as an analytical method for determining either or both a particle's identity and the presence and optionally, the concentration of one or more particular target analytes is described. Applications of these microparticle-based methods in biological and chemical assays are also disclosed.

Abstract: Microparticle-based analytical methods, systems and applications are provided. Specifically, the use of resonant resonant light scattering as an analytical method for determining either or both a particle's identity and the presence and optionally, the concentration of one or more particular target analytes is described. Applications of these microparticle-based methods in biological and chemical assays are also disclosed.

Abstract: Method and system for generating a multiple width (e.g., 16-bit width) pseudo-random number (PRN). Each of first and second 8-bit width PRNs is generated, using first and second LFSR configurations that incorporate first and second characteristic polynomials, at least one of which is irreducible. The first and second 8-bit PRNs are generated on a rising edge and on a falling edge, respectively, of a clock signal. The first and second 8-bit PRNs are combined by concatenation or by interleaving to form a 16-bit, or other multiple width, PRN.

Abstract: High speed CML logic gate systems for providing selected Boolean logic functions. Two halves of a substantially symmetric first system, having a relatively small number (14) of CMOS transistors, are used to generate any of the logic functions AND, NAND, OR and NOR. Two halves of a substantially symmetric second system having another small number (10) of transistors are used to generate any of the logic functions XOR, XNOR and NOT. In either system, the sum of currents passing through certain voltage-controlling gates is substantially constant.

Abstract: One aspect of the present invention relates to a method of creating patterned composite structures on a surface via layer-by-layer deposition of thin films. In certain embodiments, the surface is chemically patterned by the direct stamping of functional polymers on the surface film. A pattern may then be used as a template for the further depositions of materials on the surface. This concept may be applied to various functional polymer and substrate systems as well as various thin film deposition techniques.