Abstract: The present invention relates to Map4K1 inhibitors of formula (I) (I), wherein A, E, G, Q, R1, R2 and R4 have the same meaning as defined in the description, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, respectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients.

Abstract: Disclosed are a pixel circuit, a driving method thereof, and a display apparatus. The pixel circuit includes a driving sub-circuit, a writing sub-circuit, a compensation sub-circuit, a reset sub-circuit, and a light-emitting element, the driving sub-circuit provides a driving current to a third node in response to a control signal of a first node; the writing sub-circuit writes a signal of a data signal line to a second node in response to a control signal of a first scan signal line, the signal of the data signal line is a data voltage signal or a reset voltage signal; the compensation sub-circuit writes the reset voltage signal to the third node in response to a control signal of the first scan signal line; the compensation sub-circuit further compensates the first node in response to a control signal of the first scan signal line.

Abstract: Disclosed are a dynamic error measurement apparatus, system, and method for an electricity meter. The measurement apparatus includes a test signal generation unit configured to generate a voltage test signal and two-circuit current test signals, output the voltage test signal to a measurement unit, and output the two-circuit current test signals to the measurement unit and a current summation unit; the measurement unit configured to determine two-circuit electric energy values based on the voltage test signal and the two-circuit current test signals, and output the two-circuit electric energy values to a calculation control unit; the current summation unit configured to determine a combined current signal based on the two-circuit current test signals; and the calculation control unit configured to determine a total electric energy value based on the two-circuit electric energy values. The system includes a standard meter and a measurement apparatus.

Abstract: An application and a method of compounds inhibiting synthesis of very long chain fatty acids (VLCFAs) in preventing and controlling microbial pathogens are provided, which relate to the technical field of plant pathology and plant disease prevention and control. In particular, an application method of a compound for inhibiting the synthesis of VLCFAs in preventing and treating microbial pathogens is provided. Research results associated with the methods show that taking the synthesis of VLCFAs as the target, microbial pathogens can be inhibited by using compounds that inhibit the synthesis of VLCFAs. Therefore, the compounds inhibiting the synthesis of VLCFAs can be used in preventing and treating microbial pathogens diseases, which provides a new idea or strategy for the prevention and treatment of microbial pathogens diseases, and provides more choices for the types of drugs for the prevention and treatment of pathogenic diseases.

Abstract: A universal multi-orientation bracket design for attaching solenoids to a housing of a hydraulically actuated variable valve system. The bracket having at least two sidewalls, an upper cross member, a cupped lower surface and at least one mounting flange. The cupped lower surface is shaped to insert a solenoid main body and gaps included in the side walls for a protruding solenoid connector.

Abstract: A control valve for a device for variably adjusting the control times of gas-exchange valves of an internal combustion engine. The control valve has a substantially hollow cylindrical valve housing, a non-return valve and an annular filter. The annular filter is arranged within the valve housing and the non-return valve has a closing body and a spring element.

Abstract: A control valve for a device to variably adjust control times of gas-exchange valves of an internal combustion engine. The control device has a valve housing and a control piston. The valve housing has an axial cavity with a dividing element arranged in the cavity that separates the cavity into two partial spaces and hydraulically seals the spaces from one another. The dividing element is produced separately from the valve housing and is positionally fixedly fastened in the cavity of the valve housing. The first partial space holds the control piston, and a supply connection is formed in the region of the first partial space. The second partial space has at least one first opening via which pressure medium can be supplied to the second partial space by a pressure medium pump, and at least one second opening by which the second partial space communicates with the supply connection.

Abstract: A control valve for a device for variably adjusting the control times of gas-exchange valves of an internal combustion engine. The control valve has a substantially hollow cylindrical valve housing, a non-return valve and an annular filter. The annular filter is arranged within the valve housing and the non-return valve has a closing body and a spring element.

Abstract: A control valve for a device to variably adjust control times of gas-exchange valves of an internal combustion engine. The control device has a valve housing and a control piston. The valve housing has an axial cavity with a dividing element arranged in the cavity that separates the cavity into two partial spaces and hydraulically seals the spaces from one another. The dividing element is produced separately from the valve housing and is positionally fixedly fastened in the cavity of the valve housing. The first partial space holds the control piston, and a supply connection is formed in the region of the first partial space. The second partial space has at least one first opening via which pressure medium can be supplied to the second partial space by a pressure medium pump, and at least one second opening by which the second partial space communicates with the supply connection.