Abstract: The present invention discloses a method for preparing an ibuprofen spherical crystal having high bulk density and a product thereof. The method includes: (1) heating ibuprofen until a molten liquid state is reached; and (2) pressurizing the molten liquid state of ibuprofen, dropping the molten liquid state of ibuprofen into a crystallizer filled with water through a liquid distributor for crystallization under stirring conditions until the molten liquid state of ibuprofen is completely dropped, lowering the rotation speed of stirring to allow crystal growing, and finally, subjecting a resulting crystal slurry to post-treatment to obtain the ibuprofen spherical crystal having high bulk density. The ibuprofen spherical crystal has a bulk density of 0.50-0.70 g/mL, a tap density of 0.63-0.89 g/mL, a median particle size of 300-1,000 ?m and an angle of repose of 22-29°.

Abstract: In one aspect, a kit for detection of genetic gene mutation is provided, which is used for detecting nine deafness gene mutations of Caucasian populations, including GJB2 (c.35delG, c.167delT, c.132G>C, and c.269T>C), GJB6 (c.del309kb), SLC26A4 (c.707T>C and c.1246A>C), 12S rRNA (m.1555A>G and m.7444G>A). In another aspect, a method is provided, which method comprises labeling a target molecule with a luminophore, coupling the target molecule to a particle, and binding to a probe molecule on microarray. In some aspects, this technology, with high sensitivity, enables the detection and interpretation of molecular interactions in an efficient way.

Abstract: This invention relates to a single cone bit with offset axis and composite cones for oil and gas drilling, mining and other subterranean drilling operations. The bit consists of a head body and a cone. The cone section has a shape of composite cones. The outer circumference of the cone is composed of from back face of the cone to top of the cone an extended gage surface, an outer cone surface and a main cone surface. A plurality of cutting elements is mounted onto each cone surface. A head journal at lower end of the head body is for rotatablely connection with the cone. Between the axis of head journal and the axis of the bit, there is an offset value d along rotating direction of the cone. A gage pad is arranged on head body at a location opposite to the offset direction of the head journal. The gage pad is fitted with inserts or hardfaced with wear resistant alloy to prevent bit from whirling and prevent head body from being worn out and to ensure gage protection.

Abstract: This invention relates to a single cone bit with offset axis and composite cones for oil and gas drilling, mining and other subterranean drilling operations. The bit consists of a head body and a cone. The cone section has a shape of composite cones. The outer circumference of the cone is composed of from back face of the cone to top of the cone an extended gage surface, an outer cone surface and a main cone surface. A plurality of cutting elements is mounted onto each cone surface. A head journal at lower end of the head body is for rotatablely connection with the cone. Between the axis of head journal and the axis of the bit, there is an offset value d along rotating direction of the cone. A gage pad is arranged on head body at a location opposite to the offset direction of the head journal. The gage pad is fitted with inserts or hardfaced with wear resistant alloy to prevent bit from whirling and prevent head body from being worn out and to ensure gage protection.

Abstract: The invention discloses a single cone earth boring bit which is adapted to be used for boring in oil fields, mining and geological prospecting. The single cone earth boring bit is composed of a bit body (1), gauge blocks (2), active cutting gauge teeth (4), passive gauge teeth (3) and knobby cone (6) etc. On the knobby cone (6), there are inserted wear-resistant teeth intermittently or successively, so as to make the wear resistance of the bit cutting system to be matched with the service life of the bearing. At the same time, gauge blocks (2) are provided on the bit body which may be directly made on or welded to the bit body. On the gauge blocks (2), there are inserted common carbide or wear-resistant active cutting gauge teeth (4) and the passive gauge teeth (3) to enhance the gauge-protecting effect of the bit. Such a single cone earth boring bit can significantly increase the footage of the bit and reduce the cost for drilling.