Patents by Inventor Xun Zhuang

Xun Zhuang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and system for terpene production platforms in yeast
    Patent number: 11453884
    Abstract: A method is provided for producing modified mutant yeast and the resulting yeast that can be used as a platform for terpene production. The method includes chemical mutagenesis to effect ergosterol dependent growth in yeast. Subsequently, these yeast are subjected to an erg9 knockout mutation to thereby produce ergosterol dependent growth/erg9 knockout mutation yeast cell lines. The resulting yeast are well suited for use in the production of terpenes.
    Type: Grant
    Filed: August 11, 2020
    Date of Patent: September 27, 2022
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Joe Chappell, Xun Zhuang, Shuiqin Wu
  • NON-REPLICATIVE TRANSDUCTION PARTICLES AND TRANSDUCTION PARTICLE-BASED REPORTER SYSTEMS FOR DETECTION OF ACINETOBACTER BAUMANNII
    Publication number: 20220090094
    Abstract: The present invention relates to novel bacteriophages that are specific for Acinetobacter baumannii (A. baumannii) and to methods for producing non-replicative transduction particles (NRTPs) derived from these bacteriophages and to the use of the NRTPs for detection of A. baumannii.
    Type: Application
    Filed: December 22, 2019
    Publication date: March 24, 2022
    Inventors: Kathleen Y. Dunphy, Xiaowen Liu, Letong Jia, Jeffrey Alexander, Xun Zhuang
  • METHOD AND SYSTEM FOR TERPENE PRODUCTION PLATFORMS IN YEAST
    Publication number: 20210071185
    Abstract: A method is provided for producing modified mutant yeast and the resulting yeast that can be used as a platform for terpene production. The method includes chemical mutagenesis to effect ergosterol dependent growth in yeast. Subsequently, these yeast are subjected to an erg9 knockout mutation to thereby produce ergosterol dependent growth/erg9 knockout mutation yeast cell lines. The resulting yeast are well suited for use in the production of terpenes.
    Type: Application
    Filed: August 11, 2020
    Publication date: March 11, 2021
    Inventors: Joe CHAPPELL, Xun ZHUANG, Shuiqin WU
  • Method and system for terpene production platforms in yeast
    Patent number: 10738328
    Abstract: A method is provided for producing modified mutant yeast and the resulting yeast that can be used as a platform for terpene production. The method includes chemical mutagenesis to effect ergosterol dependent growth in yeast. Subsequently, these yeast are subjected to an erg9 knockout mutation to thereby produce ergosterol dependent growth/erg9 knockout mutation yeast cell lines. The resulting yeast are well suited for use in the production of terpenes.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: August 11, 2020
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Joe Chappell, Xun Zhuang, Wu Shuiqin
  • Method and System for diterpene production platforms in yeast
    Patent number: 10597665
    Abstract: A method is provided for modifying yeast to express mutant avian farnesyl disphospate synthase and the resulting modified yeast. The yeast advantageously includes additional mutants including but not limited to having ergosterol dependent growth and being erg-. The modified yeast are beneficial for the production of various terpenes including diterpenes.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: March 24, 2020
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Joe Chappell, Xun Zhuang, Shuiqin Wu