Abstract: The present disclosure provides a method of increasing the functionality of a GABAergic interneuron in the hilus of the hippocampus of an individual having at least one apolipoprotein E4 (apoE4) allele. The method generally involves reducing tau levels in the interneuron.

Abstract: An application of riluzole, a non-hormone compound, in a treatment of oligospermia provides a useful help for solving the problem of male sterility, and has potential application prospects in the field of medicine.

Abstract: A display apparatus and a method of powering the display apparatus are provided. The display apparatus includes: a main control circuit, configured to provide a first control signal; a touch display driving circuit, configured to provide a second control signal; a power supply circuit, coupled to the touch display driving circuit, and configured to provide a power supply voltage to the touch display driving circuit; and a logic circuit coupled to the main control circuit, the touch display driving circuit, and the power supply circuit, and configured to continuously enable the power supply circuit in a first mode and intermittently enable the power supply circuit in a second mode, under a control of the first control signal and the second control signal.

Abstract: The present disclosure provides an experiment platform for simulating fire in an underground traffic conversion channel, including: a model body configured to simulate fire in the an underground traffic conversion channel; a burner connected to the model body and configured to generate smoke; and a smoke imaging system including laser sheet light sources and image recording devices configured to record smoke distribution images. The laser sheet light sources are in the model body, and plane laser light emitted by the laser sheet light sources is parallel to a flow direction of the smoke. The image recording devices are in one-to-one correspondence to the laser sheet light sources and are arranged outside an observation window of the model body. One laser sheet light source and one image recording device corresponding thereto each have a filter configured to filter out laser light of a same wavelength.

Abstract: The present invention falls within the field of genetic engineering. More particularly, disclosed is a gene for expressing a fusion protein of human collagen and human fibronectin, which is expressed and purified in vitro by means of a genetic engineering method. By means of using Pichia pastoris as an expression host cell, a new-type, highly active recombinant fusion protein can be provided.

Abstract: Additive mixtures for nonaqueous battery electrolytes have been discovered that provide for improved performance, and particularly for improved lifetime (cycle life and stability) in high voltage, rechargeable lithium ion batteries. The battery electrolytes comprise less than 10% by weight of an additive mixture comprising an additive solvent, a sulfur containing compound, and lithium difluorophosphate.

Abstract: A method of driving a display panel, a driving circuit of a display panel, and a display panel are disclosed. The display panel includes a multiplexing unit and a plurality of pixels arranged in an array of M rows and N columns, the multiplexing unit includes a plurality of thin film transistors, and each thin film transistor includes a gate electrode applied with a multiplexing unit gate signal. The method includes: acquiring a plurality of data signals for driving i-th row of pixels, where 1?i?M; generating multiplexing unit gate signals for respective thin film transistors of the multiplexing unit based on the plurality of data signals; and applying the multiplexing unit gate signals to gate electrodes of the respective thin film transistors, so that the respective thin film transistors are turned on or turned off. The multiplexing unit gate signals change according to changes of the plurality of data signals.

Abstract: A display substrate has a display area and a peripheral area around the display area. The display substrate includes a plurality of sub-pixels arranged in an array in the display area, and an interface circuit, at least two serial-to-parallel converters and at least one display driver that are in the peripheral area. The interface circuit is configured to receive target data including a plurality of serial display data. A serial-to-parallel converter in the at least two serial-to-parallel converters is used to convert the plurality of serial display data into parallel display data. The serial-to-parallel converter is electrically connected to one display driver to provide the parallel display data to the display driver. The display driver is used to output display driving signals to a plurality of sub-pixels according to the parallel display data.

Abstract: A display panel and a display apparatus. The display panel includes: a substrate including a first non-display area and a display area arranged around the first non-display area; and a plurality of pixel circuits arranged in a plurality of rows in the display area, each row of the pixel circuits includes a plurality of pixel circuits arranged in the first direction, the plurality of rows of the pixel circuits are arranged in the second direction, the second direction intersects the first direction, each of the pixel circuits includes a semiconductor layer for forming an active layer of a transistor, in which the semiconductor layers of adjacent ones of the pixel circuits are spaced apart from each other.

Abstract: Methods and systems for providing controlling in a repeatable manner a plurality of anode-free or lithium metal cells in a power-supply system. The cells are connected in series in one or more high energy density hybrid modules connected in parallel. Each high energy density hybrid module includes a corresponding hybrid module controller (HMC) and has a corresponding bi-directional DC-DC-converter, and each cell of the plurality of cells is independently measurable by the HMC. The corresponding bi-directional DC-DC-converter is used to charge and discharge of the plurality of cells in a repeatable manner to be within a selected state of charge (SOC) range that corresponds to a defined cycle life and energy density requirement.

Abstract: A display substrate has a display area and a peripheral area around the display area. The display substrate includes a plurality of sub-pixels arranged in an array in the display area, and an interface circuit, at least two serial-to-parallel converters and at least one display driver that are in the peripheral area. The interface circuit is configured to receive target data including a plurality of serial display data. A serial-to-parallel converter in the at least two serial-to-parallel converters is used to convert the plurality of serial display data into parallel display data. The serial-to-parallel converter is electrically connected to one display driver to provide the parallel display data to the display driver. The display driver is used to output display driving signals to a plurality of sub-pixels according to the parallel display data.

Abstract: A method for reducing neuronal and synaptic degeneration or loss in a population of neuronal cells is provided as well as a method of treating an individual with a neurocognitive disorder. Aspects of the methods include modulating the level and/or activity of apolipoprotein E (apoE) in a population of neuronal cells where the modulating reduces the level and/or activity of an MHC pathway polypeptide in the population of neuronal cells.

Abstract: Provided are methods and compositions for identifying candidate agents for treatment of obesity, liver disease, and/or diabetes. Such methods include, e.g., contacting a mammalian cell or cell population with a test agent, and measuring an expression level and/or activity level of ClpP in the mammalian cell or in cells of the cell population. Also provided are methods and compositions for treating an individual (e.g., one who is obese and/or has diabetes). Treatment methods include administering an inhibitor of ClpP to the individual (e.g., to prevent or reduce weight gain, to increase insulin sensitivity, and/or to increase glucose tolerance).

Abstract: Provided are methods and compositions for identifying candidate agents for treatment of obesity, liver disease, and/or diabetes. Such methods include, e.g., contacting a mammalian cell or cell population with a test agent, and measuring an expression level and/or activity level of ClpP in the mammalian cell or in cells of the cell population. Also provided are methods and compositions for treating an individual (e.g., one who is obese and/or has diabetes). Treatment methods include administering an inhibitor of ClpP to the individual (e.g., to prevent or reduce weight gain, to increase insulin sensitivity, and/or to increase glucose tolerance).

Abstract: A method of driving a display panel, a driving circuit of a display panel, and a display panel are disclosed. The display panel includes a multiplexing unit and a plurality of pixels arranged in an array of M rows and N columns, the multiplexing unit includes a plurality of thin film transistors, and each thin film transistor includes a gate electrode applied with a multiplexing unit gate signal. The method includes: acquiring a plurality of data signals for driving i-th row of pixels, where 1?i?M; generating multiplexing unit gate signals for respective thin film transistors of the multiplexing unit based on the plurality of data signals; and applying the multiplexing unit gate signals to gate electrodes of the respective thin film transistors, so that the respective thin film transistors are turned on or turned off. The multiplexing unit gate signals change according to changes of the plurality of data signals.

Abstract: A display apparatus and a method of powering the display apparatus are provided. The display apparatus includes: a main control circuit, configured to provide a first control signal; a touch display driving circuit, configured to provide a second control signal; a power supply circuit, coupled to the touch display driving circuit, and configured to provide a power supply voltage to the touch display driving circuit; and a logic circuit coupled to the main control circuit, the touch display driving circuit, and the power supply circuit, and configured to continuously enable the power supply circuit in a first mode and intermittently enable the power supply circuit in a second mode, under a control of the first control signal and the second control signal.

Abstract: The present disclosure provides an experiment platform for simulating fire in an underground traffic conversion channel, including: a model body configured to simulate fire in the an underground traffic conversion channel; a burner connected to the model body and configured to generate smoke; and a smoke imaging system including laser sheet light sources and image recording devices configured to record smoke distribution images. The laser sheet light sources are in the model body, and plane laser light emitted by the laser sheet light sources is parallel to a flow direction of the smoke. The image recording devices are in one-to-one correspondence to the laser sheet light sources and are arranged outside an observation window of the model body. One laser sheet light source and one image recording device corresponding thereto each have a filter configured to filter out laser light of a same wavelength.

Abstract: The present disclosure provides methods of treating Alzheimer's Disease (AD) and rescuing cognitive deficits associated with AD in a subject having an apoE4/4 genotype, by administering a therapeutically effective amount of the loop-diuretic bumetanide to the subject. Also disclosed are kits for performing the method, including one or more doses of a bumetanide formulation; and which may also include instructions for treating a patient having an apoE4/4 genotype by administering bumetanide, and/or instructions and reagents for testing/identifying a subject having an apoE4/4 genotype.

Abstract: Provided are methods and compositions for identifying candidate agents for treatment of obesity, liver disease, and/or diabetes. Such methods include, e.g., contacting a mammalian cell or cell population with a test agent, and measuring an expression level and/or activity level of ClpP in the mammalian cell or in cells of the cell population. Also provided are methods and compositions for treating an individual (e.g., one who is obese and/or has diabetes). Treatment methods include administering an inhibitor of ClpP to the individual (e.g., to prevent or reduce weight gain, to increase insulin sensitivity, and/or to increase glucose tolerance).

Abstract: The present disclosure provides a method of increasing the functionality of a GABAergic interneuron in the hilus of the hippocampus of an individual having at least one apolipoprotein E4 (apoE4) allele. The method generally involves reducing tau levels in the interneuron.