Patents by Inventor Yahia Chebloune

Yahia Chebloune has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chimeric non-integrating lentiviral genomes as vaccines against HIV-1
    Patent number: 9879230
    Abstract: Novel nucleic acids include non-integrative chimeric retroviral genomes including the 5? and 3? long terminal repeat sequences (LTRs) of the caprine lentivirus: the Caprine Arthritis Encephalitis Virus (CAEV) or of another retrovirus not integrating human cells and at least one viral gene of another retrovirus. A vector including such a nucleic acid, an immunogenic or vaccinal composition including the vector or the nucleic acid, as well as their use for treating and/or preventing an infection by a retrovirus or a disease induced by a pathogenic agent are also described.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: January 30, 2018
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)
    Inventors: Yahia Chebloune, Delphine Aldebert, Géraldine Arrode-Bruses
  • HIV DNA vaccine regulated by a caev-derived promoter
    Patent number: 8916174
    Abstract: The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for use as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3? LTR.
    Type: Grant
    Filed: July 18, 2011
    Date of Patent: December 23, 2014
    Assignees: National Institute for Agricultural Research, University of Kansas Medical Center
    Inventors: Yahia Chebloune, Euan Narayan
  • CHIMERIC NON-INTEGRATING LENTIVIRAL GENOMES AS VACCINES AGAINST HIV-1
    Publication number: 20140370051
    Abstract: Novel nucleic acids include non-integrative chimeric retroviral genomes including the 5? and 3? long terminal repeat sequences (LTRs) of the caprine lentivirus: the Caprine Arthritis Encephalitis Virus (CAEV) or of another retrovirus not integrating human cells and at least one viral gene of another retrovirus. A vector including such a nucleic acid, an immunogenic or vaccinal composition including the vector or the nucleic acid, as well as their use for treating and/or preventing an infection by a retrovirus or a disease induced by a pathogenic agent are also described.
    Type: Application
    Filed: September 12, 2012
    Publication date: December 18, 2014
    Inventors: Yahia Chebloune, Delphine Aldebert, Géraldine Arrode-Bruses
  • HIV DNA VACCINE REGULATED BY A CAEV-DERIVED PROMOTER
    Publication number: 20120207782
    Abstract: The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for use as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3? LTR.
    Type: Application
    Filed: July 18, 2011
    Publication date: August 16, 2012
    Applicants: University of Kansas Medical Center, National Institute for Agriculture Research
    Inventors: Opendra Narayan, Euan Narayan, Yahia Chebloune
  • Avian erythroblastosis virus vectors for integration and expression of heterologous genes in avian cells
    Patent number: 5252465
    Abstract: A viral vector for the integration and expression of at least one heterologous gene in fowl pest cells consists wholly or in part of the proviral genome of fowl pest erythroblastosis or of a related virus in which said heterologous gene(s) replace(s) the v-erbA gene and/or the v-erB gene. Said gene(s) is(are) controlled either by an LTR promoter of the same virus, in which case the heterologous gene(s); mimics(s) the gene(s) it(they) replace, or by a heterologous promoter, in which case the additional att sequence is situated upstream of said heterologous promoter.
    Type: Grant
    Filed: June 25, 1990
    Date of Patent: October 12, 1993
    Assignee: Institut National de la Recherche Agronomique (IMPA)
    Inventors: Victor-Marc Nigon, Gerard Verdier, Yahia Chebloune, Francois-Loic Cosset, Catherine Legras, Astrid Reyss-Brion, Mustapha Belakebi, Francois Mallet, Pierre Savatier, Pierrick Thoraval, Jacques Samarut, Didier Poncet, Claude Bagnis, Miloud Benchaibi