Patents by Inventor Yair FASTMAN

Yair FASTMAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DUAL BINDING ANTIBODIES, METHODS OF PRODUCING DUAL BINDING ANTIBODIES, AND USES THEREOF
    Publication number: 20240101675
    Abstract: Described herein are method of generating and uses of polypeptides with dual binding specificity, wherein the polypeptides contain a first binding-site for a first antigen and a second binding-site for a second antigen. The second binding-site comprises amino acid variants of native amino acid sequences of polypeptides that bind to the first antigen, wherein the variants do not abrogate binding to said first antigen. In one embodiment, polypeptides with dual binding specificity to PD1 and OX40 are disclosed herein. In another embodiment, polypeptides with dual binding specificity to PD1 and GITR are disclosed herein.
    Type: Application
    Filed: January 20, 2022
    Publication date: March 28, 2024
    Applicant: Biolojic Design Ltd.
    Inventors: ALIK DEMISHTEIN, Dotan OMER, Schmuel BERNSTEIN, ltay LEVIN, Yehezkel SASSON, Marek STRAJBL, Sharon FISCHMAN, Guy NIMROD, Michael ZEHNIN, Reut Barak FUCHS, Olga BLUVSHTEIN YERMOLAEV, Yair FASTMAN, Oshrat Shir TWITO, Yanay OFRAN
  • ANTI-TUMOR NECROSIS FACTOR RECEPTOR (TNFR2) ANTIBODIES AND USES THEREOF
    Publication number: 20230167188
    Abstract: The present disclosure describes a number of anti-TNFR2 (tumor necrosis factor receptor 2) antibodies. These antibodies are TNFR2 agonists. In certain cases, these antibodies agonize TNFR2 in an Fc independent manner. These antibodies can modulate the proliferation and/or functions of regulatory T cells and myeloid-derived suppressor cells. In certain instances, these antibodies can be used to treat diseases such as GvHD or autoimmune diseases.
    Type: Application
    Filed: July 1, 2021
    Publication date: June 1, 2023
    Applicant: Biolojic Design Ltd.
    Inventors: Inbar AMIT, Itay LEVIN, Ayelet CHEN, Tal VANA, Nino OREN, Dor SAMET, Efrat CHOEN ZADA, Natalia LEVITIN, Guy NIMROD, Yehezkel SASSON, Alik DEMISHTEIN, Timothy WYANT, Reut BARAK FUCHS, Yair FASTMAN, Sharon FISCHMAN, Marek STRAJBL, Michael ZHENIN, Olga BLUVSHTEIN YERMOLAEV, Noam GROSSMAN, Oshrat Shir TWITO, Nevet Zur BITON, Liron DANIELPUR, May Sofia BEN MAYOR, Yanay OFRAN