Patents by Inventor Yajun Yan
Yajun Yan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11982065Abstract: A method for reinforcing soft ground by post-grouting combined with pressurized vacuum preloading is proposed, by pre-burying prefabricated vertical drains and air-boosted pipes in granular material piles, and the air-boosted pipes are used as grouting pipes to reduce the number of times of piling, which not only improves the construction efficiency, but also reduces the structural disturbance of the soil and the influence of smear effect, thus reducing the impact on the radial permeability and the radial consolidation coefficients. The method does not use geotextile bags for granular materials, which can avoid the problem of forming a localized clogging area around the geotextile bags, and the method not only improves the efficiency of vacuum transfer in a pre-consolidation stage, but also improves the grouting effect in the later stage, effectively enhances the strength of soft soil and makes granular material piles and the surrounding soil form composite ground.Type: GrantFiled: October 24, 2023Date of Patent: May 14, 2024Assignee: Nanjing Hydraulic Research InstituteInventors: Binhua Xu, Ning He, Yanbin Jiang, Zhangchun Wang, Zhikun Yan, Yanzhang Zhou, Guirong Zhang, Yajun Qian, Xinjie Zhan, Zhongliu Zhang, Bin He, Denghua Li, Yang Kong, Yuting Xie, Xiang Yin
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Publication number: 20240133144Abstract: A method for reinforcing soft ground by post-grouting combined with pressurized vacuum preloading is proposed, by pre-burying prefabricated vertical drains and air-boosted pipes in granular material piles, and the air-boosted pipes are used as grouting pipes to reduce the number of times of piling, which not only improves the construction efficiency, but also reduces the structural disturbance of the soil and the influence of smear effect, thus reducing the impact on the radial permeability and the radial consolidation coefficients. The method does not use geotextile bags for granular materials, which can avoid the problem of forming a localized clogging area around the geotextile bags, and the method not only improves the efficiency of vacuum transfer in a pre-consolidation stage, but also improves the grouting effect in the later stage, effectively enhances the strength of soft soil and makes granular material piles and the surrounding soil form composite ground.Type: ApplicationFiled: October 23, 2023Publication date: April 25, 2024Inventors: Binhua Xu, Ning He, Yanbin Jiang, Zhangchun Wang, Zhikun Yan, Yanzhang Zhou, Guirong Zhang, Yajun Qian, Xinjie Zhan, Zhongliu Zhang, Bin He, Denghua Li, Yang Kong, Yuting Xie, Xiang Yin
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Publication number: 20240112443Abstract: A max-flow/min-cut solution algorithm for early terminating a push-relabel algorithm is provided. The max-flow/min-cut solution algorithm is used for an application that does not require an exact maximum flow, and includes: defining an early termination condition of the push-relabel algorithm by a separation condition and a stable condition; determining that the separation condition is satisfied if there is no source node s, s?S, in the set T at any time in an operation process of the push-relabel algorithm; determining that the stable condition is satisfied if there is no active node in the set T; and terminating the push-relabel algorithm if both the separation condition and the stability condition are satisfied. The early termination technique is proposed to greatly reduce redundant computations and ensure that the algorithm terminates correctly in all cases.Type: ApplicationFiled: September 22, 2021Publication date: April 4, 2024Applicant: SHANGHAITECH UNIVERSITYInventors: Xinzhe LIU, Guangyao YAN, Yajun HA
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Patent number: 11934459Abstract: A ripple push method for a graph cut includes: obtaining an excess flow ef(v) of a current node v; traversing four edges connecting the current node v in top, bottom, left and right directions, and determining whether each of the four edges is a pushable edge; calculating, according to different weight functions, a maximum push value of each of the four edges by efw=ef(v)*W, where W denotes a weight function; and traversing the four edges, recording a pushable flow of each of the four edges, and pushing out a calculated flow. The ripple push method explores different push weight functions, and significantly improves the actual parallelism of the push-relabel algorithm.Type: GrantFiled: September 22, 2021Date of Patent: March 19, 2024Assignee: SHANGHAITECH UNIVERSITYInventors: Guangyao Yan, Xinzhe Liu, Yajun Ha, Hui Wang
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Patent number: 11932653Abstract: The present invention relates to the technical field of medicine, and particularly to a lycorine derivative of Formula (I), and a pharmaceutically acceptable salt, a preparation method, a pharmaceutical composition and use thereof. The lycorine derivative has obvious antiviral activity and is useful in the treatment of viral diseases such as hand-foot-mouth disease.Type: GrantFiled: July 27, 2018Date of Patent: March 19, 2024Assignees: SHANDONG DYNE MARINE BIOPHARMACEUTICAL CO., LTD, BEIJING DYNE HIGH-TECH PEDIATRIC PHARMACEUTICAL R&D INSTITUTE CO., LTD.Inventors: Xiandao Pan, Yajun Yang, Longying Shen, Wensheng Zheng, Shuwang He, Shiqiang Yan, Yajun Jing
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Publication number: 20190169664Abstract: Host cells are metabolically engineered to consume glucose and glycerol simultaneously, and to divert glucose from catabolic to anabolic pathways without adversely affecting glucose uptake.Type: ApplicationFiled: May 5, 2017Publication date: June 6, 2019Applicant: University of Georgia Research Foundation, Inc.Inventors: Yajun YAN, Yifei WU, Xinxiao SUN, Yuheng LIN
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Patent number: 10266859Abstract: 5-hydroxytryptophan (5-HTP), a precursor of serotonin, is produced in a microbial host cell. A modified bacterial phenylalanine 4-hydroxylase (P4H) catalyzes the tryptophan 5-hydroxylation reaction. Optionally the host cell includes a cofactor regeneration mechanism, allowing continuous production of 5-HTP without supplementation of exogenous cofactors.Type: GrantFiled: June 14, 2018Date of Patent: April 23, 2019Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.Inventors: Yajun Yan, Yuheng Lin
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Publication number: 20180282774Abstract: 5-hydroxytryptophan (5-HTP), a precursor of serotonin, is produced in a microbial host cell. A modified bacterial phenylalanine 4-hydroxylase (P4H) catalyzes the tryptophan 5-hydroxylation reaction. Optionally the host cell includes a cofactor regeneration mechanism, allowing continuous production of 5-HTP without supplementation of exogenous cofactors.Type: ApplicationFiled: June 14, 2018Publication date: October 4, 2018Applicant: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.Inventors: Yajun Yan, Yuheng Lin
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Patent number: 10036047Abstract: Provided herein are methods for producing an ortho-hydroxylated phenylpropanoid. In one embodiment the method includes culturing a microbe that includes HpaBC activity in the presence of a phenylpropanoid substrate. Also provided are genetically engineered microbes engineered to have greater levels of HpaB and/or HpaC than a control microbe.Type: GrantFiled: June 10, 2014Date of Patent: July 31, 2018Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.Inventors: Yajun Yan, Yuheng Lin
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Patent number: 10023889Abstract: 5-hydroxytryptophan (5-HTP), a precursor of serotonin, is produced in a microbial host cell. A modified bacterial phenylalanine 4-hydroxylase (P4H) catalyzes the tryptophan 5-hydroxylation reaction. Optionally the host cell includes a cofactor regeneration mechanism, allowing continuous production of 5-HTP without supplementation of exogenous cofactors.Type: GrantFiled: May 14, 2015Date of Patent: July 17, 2018Assignee: University of Georgia Research Foundation, Inc.Inventors: Yajun Yan, Yuheng Lin
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Publication number: 20170240939Abstract: 5-hydroxytryptophan (5-HTP), a precursor of serotonin, is produced in a microbial host cell. A modified bacterial phenylalanine 4-hydroxylase (P4H) catalyzes the tryptophan 5-hydroxylation reaction. Optionally the host cell includes a cofactor regeneration mechanism, allowing continuous production of 5-HTP without supplementation of exogenous cofactors.Type: ApplicationFiled: May 14, 2015Publication date: August 24, 2017Applicant: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.Inventors: Yajun Yan, Yuheng Lin
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Patent number: 9719113Abstract: The invention provides a recombinant microorganism that has been genetically engineered to contain metabolic pathway for the production of muconic acid from a salicylic acid intermediate. The genetically engineered metabolic pathway comprises both biosynthetic and biodegradative elements.Type: GrantFiled: December 6, 2016Date of Patent: August 1, 2017Assignee: University of Georgia Research Foundation, Inc.Inventors: Yajun Yan, Yuheng Lin
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Patent number: 9663768Abstract: The invention provides compounds, compositions, non-naturally occurring organisms, and methods useful for production of 5-hydroxytryptophan (5-HTP) in a microbial cell. A microbial system which includes at least one microbial cell, such as a bacterial cell or a yeast cell, is genetically engineered to express all or a portion of non-naturally occurring biosynthetic pathway that catalyzes the conversion of a simple carbon source, such as glucose, to 5-HTP. The invention can result in improved titers of 5-HTP and permits low-cost, large scale production. Methods of making and using the genetically engineered cells are also included in the invention.Type: GrantFiled: July 27, 2015Date of Patent: May 30, 2017Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.Inventors: Yajun Yan, Xinxiao Sun
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Publication number: 20170145447Abstract: The invention provides a recombinant microorganism that has been genetically engineered to contain metabolic pathway for the production of muconic acid from a salicylic acid intermediate. The genetically engineered metabolic pathway comprises both biosynthetic and biodegradative elements.Type: ApplicationFiled: December 6, 2016Publication date: May 25, 2017Applicant: University of Georgia Research Foundation, Inc.Inventors: Yajun Yan, Yuheng Lin
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Patent number: 9546387Abstract: The invention provides a recombinant microorganism that has been genetically engineered to contain metabolic pathway for the production of muconic acid from a salicylic acid intermediate. The genetically engineered metabolic pathway comprises both biosynthetic and biodegradative elements.Type: GrantFiled: February 13, 2015Date of Patent: January 17, 2017Assignee: University of Georgia Research Foundation, Inc.Inventors: Yajun Yan, Yuheng Lin
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Patent number: 9353390Abstract: Provided herein are methods for the biosynthesis of 4-hydroxycoumarin. In one embodiment, provided herein are genetically engineered microbes that include a metabolic pathway for the production of 4-hydroxycoumarin. Also provided are methods for using the genetically engineered microbes to produce 4-hydroxycoumarin, and using the 4-hydroxycoumarin as the starting point for the synthesis of other compounds.Type: GrantFiled: June 13, 2014Date of Patent: May 31, 2016Assignee: University of Georgia Research Foundation, Inc.Inventors: Yajun Yan, Yuheng Lin
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Patent number: 9284566Abstract: Provided herein are metabolically modified microorganisms characterized by having an increased keto-acid flux when compared with the wild-type organism and comprising at least one polynucleotide encoding an enzyme that when expressed results in the production of a greater quantity of a chemical product when compared with the wild-type organism. The recombinant microorganisms are useful for producing a large number of chemical compositions from various nitrogen containing biomass compositions and other carbon sources.Type: GrantFiled: November 3, 2011Date of Patent: March 15, 2016Assignee: The Regents of the University of CaliforniaInventors: James C. Liao, Kwang Myung Cho, Yajun Yan, Yixin Huo
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Publication number: 20160060638Abstract: The invention provides compounds, compositions, non-naturally occurring organisms, and methods useful for production of 5-hydroxytryptophan (5-HTP) in a microbial cell. A microbial system which includes at least one microbial cell, such as a bacterial cell or a yeast cell, is genetically engineered to express all or a portion of non-naturally occurring biosynthetic pathway that catalyzes the conversion of a simple carbon source, such as glucose, to 5-HTP. The invention can result in improved titers of 5-HTP and permits low-cost, large scale production. Methods of making and using the genetically engineered cells are also included in the invention.Type: ApplicationFiled: July 27, 2015Publication date: March 3, 2016Applicant: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.Inventors: Yajun Yan, Xinxiao Sun
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Patent number: 9200288Abstract: Provided herein are metabolically-modified microorganisms useful for producing 1,4-butanediol.Type: GrantFiled: April 27, 2011Date of Patent: December 1, 2015Assignee: The Regents of the University of CaliforniaInventors: James C. Liao, Yajun Yan
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Patent number: 9121044Abstract: Microorganisms are genetically engineered to synthesize caffeic acid from simple carbon sources via a tyrosine intermediate by means of a dual pathway that utilizes both endogenous and engineered enzymatic activities.Type: GrantFiled: July 9, 2014Date of Patent: September 1, 2015Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.Inventors: Yajun Yan, Yuheng Lin