Abstract: Disclosed herein are systems and methods for a method for controlling the temperature of a surface. In some embodiments, the method includes applying a variable input to a heat pump (e.g., a Peltier) in thermal communication with the surface. The variable input may vary about a voltage and may include a powered period and an unpowered period. In some embodiments, the method includes measuring a temperature of an element in thermal communication with the surface, determining, based on the temperature of the element, whether a temperature of the surface is within a safe temperature range for a user in thermal communication with the surface, in response to determining the surface is not within the safe temperature range, adjusting the voltage of the variable input to the heat pump, and in response to determining the surface is within the safe temperature range, continuing operation of the variable input at the voltage.

Abstract: Disclosed are compounds of formula (I) below: wherein each of the variables A, B, X, W, V, R1-R5, and m is defined herein. Also disclosed are pharmaceutical compositions containing a nanocomplex, wherein the nanocomplex is formed of one of the compounds, and a protein, a nucleic acid, or a small molecule; and methods of treating a medical condition with one of the pharmaceutical compositions.

Abstract: Disclosed are lipidoid compounds as well as lipidoid nanoparticles comprising such compounds.

Abstract: Disclosed are noncationic lipidoid nanoparticles (LNPs) for His-tagged protein delivery.

Abstract: A data caching method comprises: after receiving a data request sent by a client, determining a remaining valid cache duration of cache data corresponding to the data request; determining whether the remaining valid cache duration is greater than a preset update threshold value; and if the remaining valid cache duration is less than or equal to the update threshold value, updating the cache data through a database.

Abstract: Disclosed are compounds of formula (I) below: wherein each of the variables A, B, X, W, V, R1-R5, and m are defined herein. Also disclosed are pharmaceutical compositions containing a nanocomplex, wherein the nanocomplex is formed of one of the compounds, and a protein, a nucleic acid, or a small molecule; and methods of treating a medical condition with one of the pharmaceutical compositions.

Abstract: A data caching method comprises: after receiving a data request sent by a client, determining a remaining valid cache duration of cache data corresponding to the data request; determining whether the remaining valid cache duration is greater than a preset update threshold value; and if the remaining valid cache duration is less than or equal to the update threshold value, updating the cache data through a database.

Abstract: Disclosed is a liquid crystal composition and use thereof. The liquid crystal composition comprises components a, b and c; wherein component a is selected from one of the compounds represented by formula I; component b is a liquid crystal composition having a dielectric anisotropy of greater than 3; and component c is a liquid crystal composition having a dielectric anisotropy of ?3 to 3. The liquid crystal composition has a high contrast ratio property, and has a low change rate at a low temperature, that is, the decrease of contrast ratio at a low temperature (such as ?20° C.) is smaller as compared to a normal temperature. The composition has suitable properties with regard to practical applications, including a broader nematic phase range, an appropriate dielectric anisotropy, optical anisotropy and operating voltage, an excellent response time, a high electrical resistivity and voltage holding ratio, a low rotary viscosity, etc.

Abstract: Disclosed is a liquid crystal composition and use thereof. The liquid crystal composition comprises components a, b and c; wherein component a is selected from one of the compounds represented by formula I; component b is a liquid crystal composition having a dielectric anisotropy of greater than 3; and component c is a liquid crystal composition having a dielectric anisotropy of ?3 to 3. The liquid crystal composition has a high contrast ratio property, and has a low change rate at a low temperature, that is, the decrease of contrast ratio at a low temperature (such as ?20° C.) is smaller as compared to a normal temperature. The composition has suitable properties with regard to practical applications, including a broader nematic phase range, an appropriate dielectric anisotropy, optical anisotropy and operating voltage, an excellent response time, a high electrical resistivity and voltage holding ratio, a low rotary viscosity, etc.