Abstract: The present invention discloses a process and device for preparing laser PVC. The device includes an upper transmission roller, a support mechanism, a spraying mechanism, an impurity removal mechanism, and a lower transmission roller; the upper transmission roller is disposed above the lower transmission roller, and the two are configured to implement delivery of a PVC film at a station for preparing a laser layer by spraying; the support mechanism is disposed between the upper transmission roller and the lower transmission roller and is in contact with a back surface of the PVC film, and the spraying mechanism is disposed opposite to the support mechanism; and a curing mechanism is disposed in a fitting manner at the coating position; and the impurity removal mechanism is disposed at a front end of the spraying mechanism.

Abstract: A nozzle flow stirring pipe includes a pipe body and a nozzle. The pipe body is cylindrical and includes an inner pipe member and an outer pipe member. The inner pipe member has a liquid-extracting channel. The outer pipe member fits around the inner pipe member. A reflow channel is defined between an inner wall of the outer pipe member and an outer wall of the inner pipe member. The nozzle is disposed at one end of the pipe body. The inner pipe member is penetratingly disposed at the nozzle and exposed from below. The nozzle has a plurality of liquid-ejecting pores in communication with one end of the reflow channel.

Abstract: The present disclosure relates to combination therapies useful for the treatment of cancer. In particular, the disclosure relates to the combined use of a PD-1 inhibitor, a TGFbeta inhibitor, and a PARP inhibitor to treat cancer.

Abstract: An electronic device is provided. The electronic device includes a substrate, a plurality of first pads, a plurality of second pads, a first data line and a touch signal line. The substrate has a first bonding area and a second bonding area. The first pads are disposed in the first bonding area and arranged along a first direction. The second pads are disposed in the second bonding area and arranged along a second direction. There is an included angle between the first direction and the second direction. The first data line is disposed on the substrate and electrically connected to at least one of the first pads or the second pads. The touch signal line is disposed on the substrate and electrically connected to at least another one of the first pads or the second pads. The first data line at least partially overlaps the touch signal line.

Abstract: Disclosed is a compound capable of inhibiting interleukin 17A (IL-17A), which is represented by formula (I). An application of the compound or a stereoisomer thereof in the preparation of drugs for inhibiting IL-17A is also provided.

Abstract: Disclosed herein is a compound of formula (I). An application of the compound of formula (I) or a stereoisomer thereof in the preparation of a drug for inhibiting interleukin-17A (IL-17A) is further provided.

Abstract: A material mixing and supplying system is provided. The material mixing and supplying system includes a feeding module, at least three mixing and supplying barrels, a supply module, and a control unit, wherein the three mixing and supplying barrels are capable of mixing and supplying the mixed material. The supplying time of the mixed material is greater than a sum of the feeding time and the mixing time. A total operation number of the at least three mixing and supplying barrels is determined by a set amount of mixed material to be supplied by the material mixing and supplying system, and a total time to finish supplying the set amount of mixed material is determined by the total operation number.

Abstract: The present invention relates to combination therapies useful for the treatment of cancer. In particular, the invention relates to the combined use of a PD-1 inhibitor, a TGF? inhibitor, an ATM inhibitor and radiation to treat cancer.

Abstract: A lid opening component, a lid opening device, and a suction system are disclosed. The suction system includes the lid opening device and a suction assembly, wherein the lid opening device includes a positioning assembly and a lid opening assembly having the lid opening components, and the lid opening component includes a needle holder, a plurality of unpowered needles, and a drive part. The suction system identifies the locations of a container and its lids through the positioning assembly of the lid opening device, opens the container's lids by fitting the unpowered needles of the lid opening components in with the surfaces of the container's lids and rotating the lid opening components of the lid opening assembly, and by moving the suction assembly to the openings of the container, draws out the content in the container through the suction assembly.

Abstract: A quick connector assembly and a quick connector device are disclosed. The quick connector assembly includes a first base, a first fluid interface assembly and a valve assembly. The valve assembly regulates whether a fluid flows through the quick connector assembly or not, and thereby sealing the flow of the fluid at both sides of the quick connector assembly. The quick connector assembly and the quick connector device in an embodiment of the present disclosure can regulate the flow of the fluid effectively and provide better barriers to keep concurrent flows separated and isolated. Especially, the quick connector device can be used in slurry delivery system which has fluid being abrasive fluid or solid contained liquid.

Abstract: A rotary bucket mixing device is disclosed. The rotary bucket mixing device includes a main body, a rotating disk assembly, a power gear assembly and a first idler assembly. The power gear assembly receives a power to drive the rotating disk assembly to rotate and thereby rotating a mixing bucket disposed on a supporting assembly of the rotating disk assembly and mixing the contents in the mixing bucket. The first idler assembly controls a rotational speed. The rotary bucket mixing device of the present disclosure provides a better support to the mixing bucket and therefore the safety during the mixing process is enhanced.

Abstract: A nozzle flow stirring pipe includes a pipe body and a nozzle. The pipe body is cylindrical and includes an inner pipe member and an outer pipe member. The inner pipe member has a liquid-extracting channel. The outer pipe member fits around the inner pipe member. A reflow channel is defined between an inner wall of the outer pipe member and an outer wall of the inner pipe member. The nozzle is disposed at one end of the pipe body. The inner pipe member is penetratingly disposed at the nozzle and exposed from below. The nozzle has a plurality of liquid-ejecting pores in communication with one end of the reflow channel.

Abstract: This invention relates generally to a combination therapy for the treatment of cancer, particularly to a combination of (i) a bifunctional molecule comprising a TGF?RII or fragment thereof capable of binding TGF? and an antibody, or antigen binding fragment thereof, that binds to an immune checkpoint protein, such as Programmed Death Ligand 1 (PD-L1) and (ii) at least one additional anti-cancer therapeutic agent.

Abstract: A lid opening component, a lid opening device, and a suction system are disclosed. The suction system includes the lid opening device and a suction assembly, wherein the lid opening device includes a positioning assembly and a lid opening assembly having the lid opening components, and the lid opening component includes a needle holder, a plurality of unpowered needles, and a drive part. The suction system identifies the locations of a container and its lids through the positioning assembly of the lid opening device, opens the container's lids by fitting the unpowered needles of the lid opening components in with the surfaces of the container's lids and rotating the lid opening components of the lid opening assembly, and by moving the suction assembly to the openings of the container, draws out the content in the container through the suction assembly.

Abstract: The present invention discloses a compound shown in formula I or a stereoisomer, pharmaceutically acceptable salt, crystal form, solvate or isotopologue thereof. The compound of the present invention shows excellent inhibition activity against histone deacetylases, has remarkable inhibition effects on cancer cells, and provides a new choice of drugs used for the clinic treatment and diseases related to the abnormal activity of histone deacetylases.

Abstract: A liquid withdrawal system includes a base, at least one motion-enhancing element, a plurality of grip elements and a clamp. The base has a load-carrying surface and a rotational axis. The rotational axis is perpendicular to the load-carrying surface. The base is rotatable relative to the rotational axis. The motion-enhancing element is disposed on the load-carrying surface. The clamp is disposed opposite the load-carrying surface. The base and clamp jointly define a receiving space. The receiving space is adapted to receive a liquid barrel. The grip elements are movably connected to the base and symmetrically positioned relative to the base.

Abstract: The present invention relates to combination therapies useful for the treatment of cancer. In particular, the invention relates to a therapeutic combination which comprises a PD-1 axis binding antagonist, a TGF? inhibitor and a DNA-PK inhibitor, optionally together with one or more additional chemotherapeutic agents or radiotherapy. The therapeutic combination is particularly intended for use in treating a subject having a cancer that tests positive for PD-L1 expression.

Abstract: This disclosure relates generally to dosage regimens for targeted TGF-? inhibition with a bi-functional fusion protein for use in a method of treating a treatment naïve patient diagnosed with stage III non-small cell lung cancer (NSCLC), and/or mitigating a pathological condition associated with chemotherapy and radiotherapy (cCRT).

Abstract: A quick connector assembly and a quick connector device are disclosed. The quick connector assembly includes a first base, a first fluid interface assembly and a valve assembly. The valve assembly regulates whether a fluid flows through the quick connector assembly or not, and thereby sealing the flow of the fluid at both sides of the quick connector assembly. The quick connector assembly and the quick connector device in an embodiment of the present disclosure can regulate the flow of the fluid effectively and provide better barriers to keep concurrent flows separated and isolated. Especially, the quick connector device can be used in slurry delivery system which has fluid being abrasive fluid or solid contained liquid.

Abstract: A rotary bucket mixing device is disclosed. The rotary bucket mixing device includes a main body, a rotating disk assembly, a power gear assembly and a first idler assembly. The power gear assembly receives a power to drive the rotating disk assembly to rotate and thereby rotating a mixing bucket disposed on a supporting assembly of the rotating disk assembly and mixing the contents in the mixing bucket. The first idler assembly controls a rotational speed. The rotary bucket mixing device of the present disclosure provides a better support to the mixing bucket and therefore the safety during the mixing process is enhanced.