Abstract: The present disclosure relates generally to treatment and diagnosis of diseases, disorders or conditions characterized by vascular leakage. More particularly, the present disclosure relates to methods for treating a vascular leakage-associated disease or disorder in a subject; for reducing vascular leakage in a subject; for reducing reactive oxygen species production in a subject; for inducing apoptosis of neutrophils in a subject; and for increasing survival of a subject having a vascular leakage-associated disease or disorder. The methods comprise administering a G9a and/or G9a-like protein (GLP) methyltransferase inhibitor to the subject. The present disclosure further relates to methods for developing a treatment plan for a subject with a vascular leakage-associated disease, disorder or condition, and for identifying a subject as a candidate for treatment of a vascular leakage-associated disease or disorder.

Abstract: The present application discloses a negative active material, preparation process thereof and a secondary battery and the related battery module, battery pack and device. The negative active material comprises a core structure and a modified polymer coating layer coated on at least a part of the outer surface of the core structure, wherein the core structure comprises one or more of silicon-based materials and tin based materials; and wherein the negative active material has an infrared spectrum comprising an infrared absorption peak at the wavelength of 1450 cm?1 to 1690 cm?1, and the infrared absorption peak has a transmittance T that satisfies 80%?T?99%.

Abstract: Disclosed are a peptide compound and an application thereof, and a composition containing the peptide compound. The present invention provides a peptide compound YA-156, and a pharmaceutically acceptable salt, a tautomer, a solvate, a crystal form or a prodrug thereof. The compound has good stability and good activity for Kiss1R.

Abstract: Various embodiments of the present disclosure are directed towards an integrated chip including a dielectric structure sandwiched between a first electrode and a bottom electrode. A passivation layer overlies the second electrode and the dielectric structure. The passivation layer comprises a horizontal surface vertically below a top surface of the passivation layer. The horizontal surface is disposed above a top surface of the dielectric structure.

Abstract: A flexible display, including a stand, a supporting mechanism, a flexible screen, a driving component, a driven component, and a link, is provided. The supporting mechanism is connected to the stand. The flexible screen is attached to the supporting mechanism. The driving component is disposed on the stand. The driven component is disposed on a side of the supporting mechanism distant from the stand. The link has a first end and a second end opposite to the first end. The first end is connected to the driving component, and the second end is connected to the driven component. The driving component drives the driven component through the link to move on a first horizontal plane to drive the supporting mechanism and the flexible screen to transform when the driving component moves between the first horizontal plane and a second horizontal plane that is parallel to the first horizontal plane.

Abstract: The present application discloses a negative active material, preparation process thereof and a secondary battery and the related battery module, battery pack and device. The negative active material comprises a core material and a modified polymer coating layer coated on at least a part of the outer surface of the core material, the core material comprises one or more of silicon-based materials and tin based materials, the coating layer comprises carbon element and nitrogen element, wherein the nitrogen element is present in the negative active material in a mass percentage of 0.1%˜0.66%, and the coating layer comprises a —C?N-linkage.

Abstract: A memory operation method, comprising: when a first super block of a memory device is a open block (or in programming state), obtaining a first read count of one of a plurality of first memory blocks in the first super block, wherein the first read count is a number of times that data of one of the first memory blocks is read out; determining whether the first read count is larger than a first threshold; and when the first read count is larger than the first threshold, moving a part of the data in the first super block to a safe area in the memory device, wherein the part of the data comprises data in the first memory block.

Abstract: A (methyl)acrolein oxidation catalyst and a preparation method therefor-in which the catalyst has a composition represented by the following formula: x(Mo12PaCsbVcDeOf)+tC/yZ in which Mo12PaCSbVcDeOf is a heteropolyacid salt main catalyst; C is a nano carbon fiber additive, and Z is a carrier thermal conduction diluent; Mo, P, Cs, V, and O represent the elements of molybdenum, phosphorus, cesium, vanadium, and oxygen, respectively; D represents at least one element selected from the group consisting of copper, iron, magnesium, manganese, antimony, zinc, tungsten, silicon, nickel, and palladium; a, b, c, e, and f represent the atomic ratio of each element, a=0.1-3, b=0.01-3, c=0.01-5, e=0.01-2, and f being the atomic ratio of oxygen required to satisfy the valence of each of the described components; x and y represent the weights of the main catalyst and the carrier thermal conduction diluent Z, and y/x=11.1-50%; and t represents the weight of the nano carbon fiber, and t/x=3-10%.

Abstract: Disclosed is a pyridazinone compound represented by Formula (I), or a pharmaceutically acceptable salt, prodrug, hydrate, solvate, polymorph, stereoisomer, or isotopic variant thereof. The compound can be used for preparation of medicinal products for treatment and/or prophylaxis of a disease or condition associated with thyroid hormone abnormalities. The compound has higher selectivity to TH?, better pharmacokinetic parameters, desired stability, and higher agonistic activity toward TH?.

Abstract: The present disclosure discloses a method for automatically identifying south troughs by improved Laplace and relates to the technical field of meteorology. The method includes the following steps: acquiring grid data of a geopotential height field; calculating a gradient field of the geopotential height field in an x direction; searching for a turning point where a gradient value turned from being negative to being positive, and cleaning the gradient field; calculating a divergence of the x direction to obtain an improved Laplacian numerical value L?; performing 0,1 binarization processing on the L? to obtain a black-and-white image and a plurality of targets of potential troughs, merging the black-and-white image and the plurality of targets of the potential troughs by expansion, recovering original scale through erosion, and selecting an effective target through an angle of direction of a contour and an axial ratio.

Abstract: A method for controlling a device for automatically adjusting an airway opening body position is provided. The device includes a horizontal base plate, a head support block, a back support plate, a neck support apparatus, a head cover assembly, and a programmable logic controller (PLC). The neck support apparatus is positioned between the head support block and the back support plate. The PLC is configured to controls a stroke of an electric cylinder according to the following equations: ?=1.235?+?, and ?=KX+B+C, where ? is a body position angle, the body position angle is an angle between a positive projection line of a connecting line from a mandibular angle to an external acoustic meatus on a symmetrical surface of a human body and the back support plate, and ? is a preset value ranging from 90° to 100°.

Abstract: Disclosed is a system and a method for information distribution. The system comprises: a server for generating a group key and its corresponding key deriving parameter, wherein the server encrypts sensitive contents by using the group key to obtain encrypted information; and terminals configured to receive the encrypted information through an open channel, extract the group key, then decrypt the encrypted information by using the group key to obtain the original content. In the group forming process, each terminal encrypts its private identifier using the public key and submits the ciphertext to the server. In information distribution process, the server transmits the ciphertext of sensitive contents and the key deriving parameter to the terminals via open channel Because private information available only to respective group members is required for calculating the group key, this mechanism ensures that the sensitive content can be transmitted securely on the open channel.

Abstract: A positive electrode active material and a preparation method therefor, a positive electrode plate containing same, a secondary battery, and a power consuming device are provided. The positive electrode active material has a core-shell structure, comprising an inner core and a shell coating the inner core, wherein the inner core comprises Li1+xMn1?yAyP1?zRzO4, and the shell comprises a first coating layer coating the inner core, and a second coating layer coating the first coating layer, and a third coating layer coating the second coating layer. The positive electrode active material of the present application enables the secondary battery to have a higher energy density, and a good rate performance, cycling performance and safety performance.

Abstract: Provided are a negative electrode active material and a preparation method thereof, as well as a secondary battery having the same, and a battery module, a battery pack and an electrical apparatus. The negative electrode active material of the present application comprises: a silicon inner core; a first cladding layer clad on the surface of the silicon inner core, wherein the first cladding layer is a carbon-containing layer; and a second cladding layer clad on the surface of the first cladding layer, wherein the second cladding layer is an elemental sulfur layer. By using the negative electrode active material of the present application, the energy density of the secondary battery can be improved, and the cycle life can be prolonged.

Abstract: The present application provides a negative electrode active material, a process, a battery, a battery module, a battery pack and an apparatus related to the same. The negative electrode active material comprises a core material and a polymer modified coating on at least a part of a surface of core material; wherein the core material is one or more of a silicon-based negative electrode material and a tin-based negative electrode material; the negative electrode active material has a weight loss rate satisfying 0.2%?weight loss rate?2% in a thermogravimetric analysis test wherein temperature is elevated from 25° C. to 800° C. under a non-oxidizing inert gas atmosphere. The present application can reduce damage to the surface structure of the negative electrode active material, reduce loss of active ions and capacity, meanwhile can well improve coulomb efficiency and cycle performance of the battery.

Abstract: The present application provides a positive electrode active material, a preparation method therefor, a positive electrode plate, a secondary battery and a power consuming device containing same. The positive electrode active material has a core-shell structure, including an inner core and a coating layer coating at least a part of the inner core, wherein the inner core has a chemical formula of LiaAxMn1-yByP1-zCzO4-nDn, and the coating layer comprising a polymer which comprises one or more of plant polysaccharide, marine polysaccharide and their respective derivatives. The positive electrode active material of the present application enables a secondary battery to have a high energy density as well as significantly improved rate performance, cycling performance and/or high-temperature stability.

Abstract: A positive electrode active material has a core-shell structure, which includes an inner core and a coating layer coating at least part of the inner core. The inner core has a chemical formula of LiaAxMn1-yByP1-zCzO4-nDn, and the coating layer includes a polymer which includes one or more selected from polysiloxanes with linear structure and polysiloxanes with ring structure.

Abstract: A positive electrode active material and a preparation method therefor, a positive electrode plate containing same, a secondary battery, and a power consuming device are provided. The positive electrode active material has a core-shell structure, comprising an inner core and a shell coating the inner core, wherein the inner core comprises Li1+xMn1?yAyP1?zRzO4, and the shell comprises a first coating layer coating the inner core, and a second coating layer coating the first coating layer, and a third coating layer coating the second coating layer. The positive electrode active material of the present application enables the secondary battery to have a higher energy density, and a good rate performance, cycling performance and safety performance.

Abstract: A semiconductor device and a method of manufacturing the same are provided. The semiconductor device includes an antenna zone and a routing zone. The routing zone is disposed on the antenna zone, where the antenna zone includes a first insulation layer and two or more second insulation layer and a thickness of the first insulation layer is different from that of the second insulation layer.

Abstract: Quantitative susceptibility mapping methods, systems and computer-accessible medium generate images of tissue magnetism property from complex magnetic resonance imaging data using the Bayesian inference approach, which minimizes a cost function comprising of a data fidelity term and regularization terms. The data fidelity term is constructed directly from the multiecho complex magnetic resonance imaging data. The regularization terms include a prior constructed from matching structures or information content in known morphology, and a prior constructed from regions of low susceptibility contrasts characterized on image features. The quantitative susceptibility map can be determined by minimizing the cost function that involves nonlinear functions in modeling the obtained signals, and the corresponding inverse problem is solved using nonconvex optimization using a scaling approach or deep neural network.