Abstract: Implementations of this specification provide a method and an apparatus for processing ledger transactions using smart contracts in a blockchain. An example method performed by a blockchain node includes receiving data characterizing an ledger transaction for a target property, the data characterizing the ledger transaction including a unique identification code of the target property and a ledger content; generating the ledger transaction based on the data characterizing the ledger transaction for the target property, and releasing the ledger transaction to a block of the blockchain; and after the ledger transaction is verified by a consensus of the blockchain, storing the unique identification code of the target property and the ledger content in a distributed database of the blockchain.

Abstract: This disclosure relates to blockchain-based leasing. In some aspects, a leasing party node device of a blockchain network comprising a plurality of connected blockchain nodes acquires leasable state data of a target lease object based on a unique identifier that uniquely identifies the target lease object. The leasable state data is stored in a distributed database on the blockchain network and the leasable state data specifies a leasable state of the target lease object. Lease information of the target lease object is generated in response to acquiring the leasable state data. A first update transaction is transmitted to the blockchain network to update the leasable state of the target lease object. The first update transaction includes at least a portion of the lease information.

Abstract: Outputting an entry point to a target service is disclosed, including: determining that a set of sensed data that is obtained from a first device meets a condition associated with a detectable event, wherein the set of sensed data is determined by one or more sensors associated with the first device; in response to the determination, determining a target service corresponding to the detectable event; determining a selected device among the first device and at least one second device, wherein the at least one second device is related to the first device; and outputting an entry point corresponding to the target service to the selected device, wherein the entry point is usable to access the target service.

Abstract: The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.

Abstract: Neuropeptide FF receptor modulators based on a proline scaffold are provided which offer NPFF receptor potencies in the nanomolar range and antagonistic selectivity for the NPFF1 receptor. Methods, compounds and compositions for modulating the function of neuropeptide FF receptors are provided for pharmacotherapies capable of influencing conditions or disorders affected by the neuropeptide FF receptors.

Abstract: This disclosure is directed to various compounds and methods of preparation of improved compounds that are capable of functioning as cannabinoid receptor 1 (CB1) antagonists with reduced central nervous system (CNS) side effects. The application is also directed to pharmaceutical compositions containing one or more of these compounds, which may also contain one or more additional therapeutic agents. It is also directed to methods of treatment of various conditions that may be responsive to antagonism of the CB1 receptors, including, but not limited to, metabolic syndromes (including liver disease, obesity, and diabetes).

Abstract: Technologies are described for selective persistence of data utilized by software containers. A configuration policy is defined that includes data that specifies one or more data stores for which data is not to be persisted following accesses to a software container and one or more data stores for which data is to be persisted following accesses to the software container. When the software container is first accessed, the data stores identified in the configuration policy are attached to the software container. Upon a subsequent access to the container, such as at the conclusion of a user session or upon destruction of the container, the data in the attached data stores is persisted or deleted based upon the configuration policy. When the software container is once again accessed, the data store containing the persisted data can be re-attached to the software container.

Abstract: Target application information for validation is received at a network device from user equipment. The received target application information is validated. Risk information associated with the validated target application information is determined. Based on the determined risk information, prompt information is returned to the user equipment.

Abstract: Embodiments of the disclosure provide a method and apparatus for recommending video data. In one embodiment, a method is disclosed comprising: retrieving, by a server device, text data and video data; generating, by the server device, a relationship graph, the relationship graph representing a semantic mapping of the text data; generating, by the server device, candidate video segment data based on the video data, the candidate video segment data comprising semantic tag data; acquiring, by the server device, target video data according to the relationship graph and the candidate video segment data; and transmitting, by the server device, the target video data to a client device. The embodiments of the disclosure can screen and select personalized target video data from big video data according to a relationship graph showing a semantic mapping without human assistance during the whole process, greatly improving the video content browsing experience of users and increasing the conversion rate.

Abstract: The invention provides compounds capable of acting as antagonists at cannabanoid receptors according to the following formula: Such compounds may be used to treat conditions for which the cannabinoid receptor system has been implicated, such as obesity, liver disease, diabetes, pain, and inflammation.

Abstract: Selectively permeable membranes for biosensors are provided. In one embodiment, the membrane includes a polymer mixture that includes a polyurethane component, a siloxane component, and a hydrogel component, the components in the mixture in amounts of about 60 to about 80 wt % polyurethane, about 10 to about 20 wt % siloxane, and about 10 to about 20 wt % hydrogel. The membrane has a surface restructured to be hydrophilic, with the restructured surface being crosslinked via reactive end groups on at least one of the polyurethane, the siloxane, and the hydrogel components.

Abstract: Selectively permeable membranes for biosensors are provided. In one embodiment, the membrane includes a polymer mixture that includes a polyurethane component, a siloxane component, and a hydrogel component, the components in the mixture in amounts of about 60 to about 80 wt % polyurethane, about 10 to about 20 wt % siloxane, and about 10 to about 20 wt % hydrogel. The membrane has a surface restructured to be hydrophilic, with the restructured surface being crosslinked ed via reactive end groups on at least one of the polyurethane, the siloxane, and the hydrogel components. In another embodiment, the membrane includes a solvent cast film which includes a mixture of a first polyether-based thermoplastic polyurethane copolymer, a polyether-based polyurethane copolymer, and, optionally, a second polyether-based thermoplastic polyurethane copolymer.

Abstract: The invention provides compounds capable of acting as antagonists at cannabanoid receptors according to the following formula: Such compounds may be used to treat conditions for which the cannabinoid receptor system has been implicated, such as obesity, liver disease, diabetes, pain, and inflammation.

Abstract: The invention provides compounds capable of acting as antagonists at cannabanoid receptors according to the following formula: Such compounds may be used to treat conditions for which the cannabinoid receptor system has been implicated, such as obesity, liver disease, diabetes, pain, and inflammation.

Abstract: Neuropeptide S receptor antagonists are provided that bind in functional assays to neuropeptide S receptors; methods are provided for use of these antagonists in treatment of conditions or disease states that are ameliorated by blocking of the neuropeptide S receptor, including substance abuse and substance abuse relapse; and for use of neuropeptide S receptor antagonists in the manufacture of therapeutics and pro-drugs for therapeutics useful in disease states and conditions sensitive to binding of the neuropeptide S receptor.

Abstract: The invention provides compounds capable of acting as antagonists at cannabanoid receptors according to the following formula: Such compounds may be used to treat conditions for which the cannabinoid receptor system has been implicated, such as obesity, liver disease, diabetes, pain, and inflammation.

Abstract: Neuropeptide S receptor antagonists are provided that bind in functional assays to neuropeptide S receptors; methods are provided for use of these antagonists in treatment of conditions or disease states that are ameliorated by blocking of the neuropeptide S receptor, including substance abuse and substance abuse relapse; and for use of neuropeptide S receptor antagonists in the manufacture of therapeutics and pro-drugs for therapeutics useful in disease states and conditions sensitive to binding of the neuropeptide S receptor.

Abstract: The invention provides compounds capable of acting as antagonists at cannabanoid receptors according to the following formula: Such compounds may be used to treat conditions for which the cannabinoid receptor system has been implicated, such as obesity, liver disease, diabetes, pain, and inflammation.

Abstract: An implantable sensing system that includes a sensor for sensing a biological parameter, a processor connected to the sensor for processing the parameter and a drug delivery unit connected to the processor for responding to the processor based on the parameter. The processor is programmed to adjust an output of the sensor by compiling an array of data relating to the sensor, adjusting a sensor parameter a first time based on data in the array, adjusting a curve representing the sensor output based on data in the array and adjusting the sensor parameter a second time based on data in the array.