Abstract: Provided is an NK inhibitory molecule, which includes one or more NK inhibitory ligands, a transmembrane domain and a co-stimulatory domain, wherein the NK inhibitory ligand specifically binds to NK inhibitory receptors to inhibit the killing of NK cells against the engineered immune cells expressing the NK inhibitory molecule. Also provided is an engineered immune cell expressing the NK inhibitory molecule of the present invention, wherein the expression of at least one MHC-related gene is suppressed or silenced. Further provided is the use of the engineered immune cell in the treatment of cancers, infections or autoimmune diseases. Compared to the traditional engineered immune cells, the engineered immune cell can significantly inhibit the killing effect of NK cells in a subject, thereby reducing the risk of HvGD.

Abstract: A boron-sulfur-codoped porous carbon material and a preparation method is disclosed. The boron-sulfur-codoped porous carbon material includes a porous carbon, and B and S doped in the surface and pores of the porous carbon; where B has a doping content of 5.56 wt.% to 7.85 wt.%, and S has a doping content of 0.90 wt.% to 1.55 wt.%. Test results of examples show that the boron-sulfur-codoped porous carbon material has high doping contents of B and S, and abundant pores; in a three-electrode system, the material shows a maximum specific capacitance of 168 F·g- 1 to 290.7 F·g-1 at 0.5 A·g-1; after the material is assembled into a symmetrical supercapacitor, the supercapacitor has an ultra-high energy density of 11.3 Wh·kg-1 to 16.65 Wh·kg-1 in a neutral electrolyte system, and has a capacitance retention rate of 97.09% to 100.67% after 10,000 life tests.

Abstract: A urine-derived mesenchymal stem cell mitochondria as well as a transplantation method and use thereof. The urine-derived mesenchymal stem cell mitochondrion is extracted from urine to be used for improving the quality of oocytes. The transplantation method comprises: jointly injecting sperms and the urine-derived mesenchymal stem cell mitochondria into mature oocytes for blastaea culture during the intracytoplasmic sperm microinjection.

Abstract: An engineered immune cell, which expresses (i) a cell surface molecule that specifically recognizes a ligand, (ii) an exogenous interleukin, and (iii) an exogenous Flt3L, XCL2, and/or XCL1; the engineered immune cell can be used for treating cancer, infection, or autoimmune diseases; and compared with a traditional engineered immune cell, the engineered immune cell has significantly improved tumor killing activity.

Abstract: A pixel structure, a display substrate and a driving method therefor, and a display device. The pixel structure includes a plurality of pixel units; each pixel unit comprises a first sub-pixel, a second sub-pixel, a third sub-pixel, and a central sub-pixel; the central sub-pixel is located in an area enclosed by the first sub-pixel, the second sub-pixel, and the third sub-pixel; the minimum distance from the central sub-pixel to at least one of the first sub-pixel, the second sub-pixel, and the third sub-pixel in a same pixel unit is less than the distance between two adjacent pixel units.

Abstract: The present application provides a method, a device, and a system of vibration reduction control on the installation of a deepwater drilling riser. The method includes: determining a lateral vibration displacement of each position of the riser at different times in an installation process according to a mechanical model of the deepwater drilling riser in the installation process, determining a stress generated by a lateral vibration of the riser in the installation process, determining a vibration reduction control speed applied to a bottom of the riser in the installation process according to the stress and the lateral vibration displacement of each position of the riser at different times in the installation process, and performing a vibration reduction control on the bottom of the riser based on the vibration reduction control speed.

Abstract: The present application provides a method, a device, and a system of vibration reduction control on the installation of a deepwater drilling riser. The method includes: determining a lateral vibration displacement of each position of the riser at different times in an installation process according to a mechanical model of the deepwater drilling riser in the installation process, determining a stress generated by a lateral vibration of the riser in the installation process, determining a vibration reduction control speed applied to a bottom of the riser in the installation process according to the stress and the lateral vibration displacement of each position of the riser at different times in the installation process, and performing a vibration reduction control on the bottom of the riser based on the vibration reduction control speed.

Abstract: The present disclosure provides a two-stroke pumping method and oil production device, and relates to the technical field of oil production. The oil production device comprises a pump body, wherein the oil production device further comprises a central tube of a hollow structure, and the central tube is partially located in the pump body and coaxially arranged with the pump body; a traveling valve and a standing valve are arranged on the left side and the right side of the outer wall of the central tube respectively, and the traveling valve is arranged between the pump body and the central tube; the standing valve is located outside the pump body; the traveling valve and the standing valve are matched with the pump body and the central tube to form an oil pumping space; and an oil pumping assembly is further arranged in the oil pumping space.

Abstract: A downhole displacement impact method and an impact drilling tool are provided, which relates to the field of drilling tools. The downhole displacement impact drilling tool includes a flow passing sleeve, a first main shaft, an impact-bearing seat, and a second main shaft that are all formed by annular structures and are connected in sequence from top to bottom. A vibration sleeve, a vibration starting seat, and an impact head are connected in sequence from top to bottom on the impact-bearing seat. The vibration sleeve is connected and fixed to the impact head through a connecting sleeve. The vibration starting seat synchronously rotates with the impact-bearing seat through a spline connection therebetween. The vibration starting seat generates an up-down periodic displacement along an axial direction of the vibration starting seat during rotating.

Abstract: Provided are a drive method of a display panel, a storage medium, a drive device and a display device. The drive method includes: in an Nth frame, applying a first voltage to the second electrode and a first data signal matched with a first voltage to the first electrode through the pixel drive circuit based on grayscale data of the Nth frame; wherein N is a positive integer; in an (N+1)th frame applying a second voltage to the second electrode and a second data signal matched with the second voltage to the first electrode through the pixel drive circuit based on grayscale data of the (N+1)th frame, wherein the first voltage is different from the second voltage.

Abstract: A display substrate includes a base substrate including a display region and a peripheral region located on at least one side of the display region. The display region is provided with a plurality of sub-pixels, and at least one of the plurality of sub-pixels includes a light-emitting element and a pixel circuit for driving the light-emitting element. The peripheral region includes a detection region, and the detection region is provided with at least one detection electrode which is electrically connected with a first electrode of the light-emitting element and the pixel circuit through a detection lead wire, to detect electrical performance of the light-emitting element through the detection electrode in a detection stage.

Abstract: A casing hanger and annulus sealing device running tool for deepwater drilling and a method for using the same. The running tool includes a spindle connected to a hollow suspension structure via a torque transmission structure, one end of the spindle slidably passes through a hollow piston, the suspension structure rotates with the spindle and slide along the piston, the inner cavity of the torque transmission structure communicates with that of the suspension structure to form a piston cavity; the piston cavity and the piston form a hydraulic piston structure; and one end of the suspension structure away from the torque transmission structure can rotatably hook to and lift upward to release the annulus sealing device, and one end of the piston away from the torque transmission structure can radially expand to hook to the casing hanger and can radially contract to release the casing hanger.

Abstract: The application provides a plaster casting mold fabrication method for a complicated structure aluminum alloy casting with a large inner cavity and a thin wall, in which, a wax pattern is cleaned with a mixture; closed blind cavity and large plane unbeneficial to plaster mold-filling of the wax pattern are used to exhaust air by using vent holes and waterproof-breathable membranes in cooperation with each other; under pressure difference, plaster powder and mixed aqueous solution are vertically splashed and mixed in a mixing tank to reduce dust discharge; asynchronous mixing and grouting can be realized by left and right mixing tanks in an upper tank of a vacuum tank. The present application can effectively remove the surface parting agent, increase the wettability of the plaster paste and the wax pattern surface, and improve the surface finish of the casting mold.

Abstract: A method for vacuum smelting and variable pressure solidification forming aluminum alloy piece with ultra-thin wall and high gas tightness is provided, in which an induction heating furnace is set in a vacuum tank, a quartz crucible with thickness of 5˜8 mm is used; a preheated aluminum alloy ingot is placed in the crucible, side doors of the tank is closed, and a vacuuming processing is performed for the tank; the melt is filled from the bottom layer of the casting; when the melt reaches to the top, the main valve and the air-release valve are turned on until the inside and outside pressures are consistent, and then the casting is taken out. The requirement of high air tightness for vacuum tank is reduced, and aluminum alloy casting with high quality can be obtained at lower cost.

Abstract: A casing hanger and annulus sealing device running tool for deepwater drilling and a method for using the same. The running tool includes a spindle connected to a hollow suspension structure via a torque transmission structure, one end of the spindle slidably passes through a hollow piston, the suspension structure rotates with the spindle and slide along the piston, the inner cavity of the torque transmission structure communicates with that of the suspension structure to form a piston cavity; the piston cavity and the piston form a hydraulic piston structure; and one end of the suspension structure away from the torque transmission structure can rotatably hook to and lift upward to release the annulus sealing device, and one end of the piston away from the torque transmission structure can radially expand to hook to the casing hanger and can radially contract to release the casing hanger.

Abstract: The application provides a plaster casting mold fabrication method for a complicated structure aluminum alloy casting with a large inner cavity and a thin wall, in which, a wax pattern is cleaned with a mixture; closed blind cavity and large plane unbeneficial to plaster mold-filling of the wax pattern are used to exhaust air by using vent holes and waterproof-breathable membranes in cooperation with each other; under pressure difference, plaster powder and mixed aqueous solution are vertically splashed and mixed in a mixing tank to reduce dust discharge; asynchronous mixing and grouting can be realized by left and right mixing tanks in an upper tank of a vacuum tank. The present application can effectively remove the surface parting agent, increase the wettability of the plaster paste and the wax pattern surface, and improve the surface finish of the casting mold.

Abstract: A method for vacuum smelting and variable pressure solidification forming aluminum alloy piece with ultra-thin wall and high gas tightness is provided, in which an induction heating furnace is set in a vacuum tank, a quartz crucible with thickness of 5˜8 mm is used; a preheated aluminum alloy ingot is placed in the crucible, side doors of the tank is closed, and a vacuuming processing is performed for the tank; the melt is filled from the bottom layer of the casting; when the melt reaches to the top, the main valve and the air-release valve are turned on until the inside and outside pressures are consistent, and then the casting is taken out. The requirement of high air tightness for vacuum tank is reduced, and aluminum alloy casting with high quality can be obtained at lower cost.

Abstract: The present invention belongs to the field of bio-pharmaceutical material preparation technology, and relates to a preparation method of albumin nanoparticle carrier entrapping taxane-typed drug. This preparation method rapidly forms nanoparticle solution of albumin entrapping taxane-typed drug under room temperature by adding solvent as the medium. Next, by the second time of freeze-drying, stable powder of albumin nanoparticles entrapping taxane-typed drug is obtained. The final freeze-dried powder only includes two components: albumin and taxane-typed drug. The particles are in regular spherical shape, and the diameter of particle is less than 100 nm. The present invention has high drug loading ratio and entrapment efficiency. The experiment of releasing in vitro shows that the present invention has a good slow-release effect. Taxane-typed drug nanoparticles provided by the present invention improves the safety and compliance of this type of reagent.

Abstract: Disclosed is a process for one-step preparing electrolyte used for lithium-iron(II) disulfide batteries. The process includes the following steps of: adding iodine-containing precursors into an organic solvent in an inert atmosphere, homogeneously stirring, then adding lithium-containing precursors, stirring and reacting, separating solids to obtain an electrolyte used for lithium-iron(II) disulfide batteries. The process involves one-step synthesizing electrolyte used for lithium-iron(II) disulfide batteries. The whole procedures do not introduce water and have a lower cost. The lithium-iron(II) disulfide batteries prepared by using the electrolyte prepared by the process of the present invention have better properties.

Abstract: The present invention belongs to the field of bio-pharmaceutical material preparation technology, and relates to a preparation method of albumin nanoparticle carrier entrapping taxane-typed drug. This preparation method rapidly forms nanoparticle solution of albumin entrapping taxane-typed drug under room temperature by adding solvent as the medium. Next, by the second time of freeze-drying, stable powder of albumin nanoparticles entrapping taxane-typed drug is obtained. The final freeze-dried powder only includes two components: albumin and taxane-typed drug. The particles are in regular spherical shape, and the diameter of particle is less than 100 nm. The present invention has high drug loading ratio and entrapment efficiency. The experiment of releasing in vitro shows that the present invention has a good slow-release effect. Taxane-typed drug nanoparticles provided by the present invention improves the safety and compliance of this type of reagent.