Patents by Inventor Yanfeng Zhang

Yanfeng Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL CRYSTAL FORM OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOLE-5-YL)CYCLOPROPANE FORMAMIDO)-3-METHYLPYRIDINE-2-YL)BENZOIC ACID AND PREPARATION METHOD THEREOF
    Publication number: 20180230136
    Abstract: The present disclosure provides crystalline form A of 3-(6-(1-(2, 2-difluorobenzo [d] [1, 3] dioxo-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid and process of preparation thereof. The crystalline form A has low hygroscopicity, good stability, is convenient to store. It has higher solubility than that of prior art and therefore plays an important role in further optimization and development of the drug.
    Type: Application
    Filed: August 11, 2016
    Publication date: August 16, 2018
    Applicant: CRYSTAL PHARMATECH CO., LTD.
    Inventors: Minhua CHEN, Yanfeng ZHANG, Kai LIU, Po ZOU, Xiaoyu ZHANG
  • Method and mobile vehicle platform device for drying biomass fuel
    Patent number: 10036592
    Abstract: A method for drying biomass fuel, including: 1) collecting and cutting raw biomass fuel into fragments; mechanically squeezing and dehydrating the fragments to yield biomass fuel in the form of filter cake; 2) mashing and loosening the biomass fuel in the form of filter cake; and loading the biomass fuel onto charging carriages of fuel transport vehicles; 3) connecting tails of the fuel transport vehicles and the carrier vehicle of drying equipment; moving the movable drying room of the carrier vehicle of drying equipment onto the fuel transport vehicles; 4) convectively drying the biomass fuel in the charging carriages; 5) exhausting air in the movable drying room following convective drying; and 6) moving the movable drying room to cover and seal the charging carriages of a next fuel transport vehicle following radiant drying. A mobile device for drying biomass fuel is also provided.
    Type: Grant
    Filed: May 27, 2017
    Date of Patent: July 31, 2018
    Assignee: ZHONGYING CHANGJIANG INTERNATIONAL NEW ENERGY INVESTMENT CO., LTD.
    Inventors: Yilong Chen, Shuchuan Hu, Yanfeng Zhang
  • CRYSTALLINE FORMS OF TRISODIUM SUPRAMOLECULAR COMPLEX COMPRISING VALSARTAN AND AHU-377 AND METHODS THEREOF
    Publication number: 20180201589
    Abstract: Novel crystalline forms of trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl) propionate-(S)-3?-methyl-2?-(pentanoyl{2?-(tetrazol-5-ylate)biphenyl-4?-ylmethyl}amino)butyrate] hydrate, methods for their preparation, pharmaceutical compositions comprising these new forms, and use of them for treating or delaying progression or onset of diseases or disorders related to activity of angiotensin receptor 1 (AT1) blockage and neprilysin (NEP) inhibition, such as heart failure, are disclosed.
    Type: Application
    Filed: March 18, 2018
    Publication date: July 19, 2018
    Inventors: Minhua CHEN, Yanfeng ZHANG, Chaohui YANG, Xiaoyu ZHANG
  • Integrated solar energy drying system
    Patent number: 10018415
    Abstract: An integrated solar energy drying system, including: a solar greenhouse, a solar energy storage bed, an air condenser, a wet dust collector, pipes, valves, and blowers. The solar greenhouse includes: a top side, three sunny sides, a shady side, floorboards, a gas inlet, and two gas outlets. The solar energy storage bed includes: an upper air box, a lower air box, a plurality of solar heat collecting-storing pipes, and a sealing chamber. Each solar heat collecting-storing pipe includes an air pipe. The air condenser includes: an air inlet, an air outlet, two gas chambers, and a bundle of gas pipes. The solar greenhouse, the solar energy storage bed, the air condenser, the wet dust collectors are connected via pipes. The valves and the blowers are disposed on the pipes.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: July 10, 2018
    Assignee: ZHONGYING CHANGJIANG INTERNATIONAL NEW ENERGY INVESTMENT CO., LTD.
    Inventors: Yilong Chen, Shuchuan Hu, Yanfeng Zhang
  • Method for modifying bio-oil derived from biomass pyrolysis
    Patent number: 10005966
    Abstract: A method for modifying bio-oil derived from biomass pyrolysis, the method including: 1) adding an inorganic salt and an organic demulsifier to a bio-oil; oscillating or stirring the resulting mixture, and resting the resulting mixture, to yield a lower layer being an aqueous solution and an upper layer being the bio-oil, and collecting the bio-oil; 2) employing a zeolite molecular sieve-loaded clay as a catalyst, and aging the catalyst using pure steam, to yield a modified catalyst; and 3) adding the modified catalyst obtained in 2) to a conventional catalytic cracking reactor, injecting the bio-oil obtained in 1) to the conventional catalytic cracking reactor using a piston pump, and allowing the bio-oil to react under a weight hourly space velocity (WHSV) of between 6 and 15 h?1, a temperature of between 380 and 700° C., and a pressure between 0.1 and 0.8 megapascal.
    Type: Grant
    Filed: November 8, 2015
    Date of Patent: June 26, 2018
    Assignee: WUHAN KAIDI ENGINEERING TECHNOLOGY RESEARCH INSTITUTE CO., LTD.
    Inventors: Dashan Wang, Dechen Song, Qianqian Liu, Shenke Zheng, Xiaodong Zhan, Jiaqi Jin, Yanfeng Zhang
  • CRYSTALLINE FORM A OF OBETICHOLIC ACID AND PREPARATION METHOD THEREOF
    Publication number: 20180170958
    Abstract: The present invention relates to crystalline Form A of obeticholic acid and the preparation method thereof. The present invention provides Form A having characteristic peaks at 2theta value of 4.9°±0.2°, 5.2°±0.2°, 9.9°±0.2°. The present invention provides a novel crystalline form of obeticholic acid, which has good stability, good processability and other favorable properties, and is suitable for storage and usage as a final product. In addition, the preparation method is simple, low cost, and has great value for the future optimization and development of obeticholic acid.
    Type: Application
    Filed: December 30, 2015
    Publication date: June 21, 2018
    Applicant: Crystal Pharmatech Co., Ltd.
    Inventors: Minhua CHEN, Yanfeng ZHANG, Xiaojuan Diao, Xiaoyu Zhang
  • CRYSTALINE FORMS OF N-[6-(CIS-2,6-DIMETHYLMORPHOLINE -4-YL)PYRIDINE-3-YL]-2-METHYL-4'-(TRIFLUOROMETHOXY) [1,1'-BIPHENYL]-3-METHANAMIDE MONOPHOSPHATE, AND PROCESS OF PREPARATION THEREOF
    Publication number: 20180170919
    Abstract: The present disclosure relates to novel crystalline forms of N-[6-(cis-2,6-dimethylmorpholine-4-yl)pyridine-3-yl]-2-methyl-4?-(trifluoromethoxy) [1,1?-biphenyl]-3-carboxamide monophosphate, and process of preparation thereof. The crystalline form of the monophosphate of a compound of formula (I) has low hygroscopicity, is convenient to store, has better stability than that of diphosphonate in prior art, can avoid the risk of crystal transformation in the development and production of the drug. The preparation method is simple, has low cost, and has important value for further optimization and development of the drug.
    Type: Application
    Filed: March 30, 2016
    Publication date: June 21, 2018
    Applicant: CRYSTAL PHARMATECH CO., LTD.
    Inventors: Minhua CHEN, Yanfeng ZHANG, Fei LU, Xiaoyu ZHANG
  • Salt of pyrrolo[2,3-D]pyrimidine compound and novel polymorph of salt
    Patent number: 9994579
    Abstract: The present invention relates to novel crystalline forms of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-car boxylic acid dimethylamide(compound I), its salts, and process for preparation thereof. Crystalline forms in the present invention have good stability, low hygroscopicity, good processability, easy treatability and other favorable properties. In addition, the process is simple, low cost, and has an important value for future optimization and development of the drug.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: June 12, 2018
    Assignee: Crystal Pharmatech Co., Ltd.
    Inventors: Minhua Chen, Yanfeng Zhang, Kai Liu, Jiaoyang Li, Xiaoyu Zhang
  • NEW CRYSTAL FORM OF LENVATINIB METHANESULFONATE SALT AND PREPARATION METHOD THEREOF
    Publication number: 20180155291
    Abstract: The present disclosure relates to a novel crystalline form of lenvatinib mesylate and the preparation method thereof. The novel crystalline form of mesylate of the present disclosure can be used for treating invasive and differentiated thyroid cancer. The novel crystalline form of mesylate of the present disclosure has good solubility, stability, and remarkable purification effect in process. The preparation method of this novel crystalline form is simple, low cost, and has an important value for future optimization and development of the drug.
    Type: Application
    Filed: June 8, 2016
    Publication date: June 7, 2018
    Applicant: CRYSTAL PHARMATECH CO., LTD
    Inventors: Minhua CHEN, Yanfeng ZHANG, Xiaojuan DIAO, Xiaoyu ZHANG
  • Salts and co-crystals of lesinurad
    Patent number: 9969701
    Abstract: Novel salts and cocrystals of lesinurad, processes for their preparation, pharmaceutical compositions comprising these new salt forms and co-crystals, and use of them for treating or delaying progression or onset of diseases or disorders related to activity of uric acid transport 1 (URAT1) proteins are disclosed. These novel forms were characterized by X-ray powder diffraction, differential scanning calorimetry, and other techniques. They can be readily prepared and are suitable for preparation of solid dosage forms owing to their ease of handling and superior pharmacological properties.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: May 15, 2018
    Assignees: Crystal Pharmatech Co., Ltd., Suzhou Pengxu Pharmatech Co., Ltd.
    Inventors: Minhua Chen, Yanfeng Zhang, Chaohui Yang, Xiaoyu Zhang, Peng Wang, Pixu Li
  • Method and device for supplying heat energy and carbon dioxide from exhaust gas for vegetable and/or algae production
    Patent number: 9961840
    Abstract: A method for supplying heat energy and carbon dioxide for vegetables and/or algae production using exhaust gas. The method includes: 1) introducing the exhaust gas to a primary heat exchanger to conduct a first indirect heat exchange between the exhaust gas and air from a vegetable greenhouse and/or an algae culturing house, thereby providing hot air for the vegetable greenhouse and/or the algae culturing house; 2) introducing part of the exhaust gas after the first indirect heat exchange to a secondary heat exchanger to conduct a second indirect heat exchange between the exhaust gas and outdoor air; 3) introducing the exhaust gas to a CO2 pressure swing adsorption device, separating and pumping carbon dioxide to a carbon dioxide storage tank for storage; and 4) supplying the carbon dioxide to the vegetable greenhouse and/or a carbon-absorption tank of the algae culturing house.
    Type: Grant
    Filed: September 28, 2013
    Date of Patent: May 8, 2018
    Assignee: Sunshine Kaidi New England Group Co., Ltd.
    Inventors: Yilong Chen, Shuchuan Hu, Yanfeng Zhang
  • METHOD AND DEVICE FOR PREPARING ACTIVE PARTICLE-CONTAINING STEAM
    Publication number: 20180117559
    Abstract: A device for preparing a high-temperature and active particle-containing steam. The device includes a steam generator including an inlet for introducing a plasma medium and an inlet for introducing a steam. In the steam generator, the steam is heated and activated by the plasma medium to form an active particle-containing steam which improves the gasification rate and efficiency in the gasification of coal, biomass, and garbage.
    Type: Application
    Filed: October 24, 2017
    Publication date: May 3, 2018
    Inventors: Yilong CHEN, Yanfeng ZHANG, Minxia CAO, Hong LI
  • Crystalline forms of trisodium supramolecular complex comprising valsartan and AHU-377 and methods thereof
    Patent number: 9957240
    Abstract: Novel crystalline Forms of trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butyl carbamoyl) propionate-(S)-3?-methyl-T-(pentanoyl{2?-(tetrazol-5-ylate)biphenyl-4?-ylmethyl}amino)butyrate] hydrate, methods for their preparation, pharmaceutical compositions comprising these new forms, and use of them for treating or delaying progression or onset of diseases or disorders related to activity of angiotensin receptor 1 (AT1) blockage and neprilysin (NEP) inhibition, such as heart failure, are disclosed.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: May 1, 2018
    Assignees: CRYSTAL PHARMATECH CO., LTD, SUZHOU PENGXU PHARMATECH CO., LTD.
    Inventors: Minhua Chen, Yanfeng Zhang, Chaohui Yang, Xiaoyu Zhang, Jiaoyang Li, Peng Wang, Pixu Li
  • METHOD AND APPARATUS FOR PURIFYING AND COOLING BIOMASS SYNGAS
    Publication number: 20180105759
    Abstract: A method for purifying and cooling biomass syngas. The method includes: 1) cooling biomass syngas to 520-580° C., and recycling waste heat to yield a first steam; then subjecting the biomass syngas to cyclone dust removal treatment; and further cooling the biomass syngas to a temperature of ?210° C., and recycling waste heat to yield a second steam; 2) removing a portion of heavy tar precipitating out of the biomass syngas during the second-stage indirect heat exchange; 3) carrying out dust removal and cooling using a scrub solution, to scrub off most of dust, tar droplets, and water soluble gases from the biomass syngas after the heat exchange and dust removing treatment; and 4) conducting deep removal of dust and tar with a wet gas stream, to sweep off remains of dust and tar fog in the scrubbed biomass syngas.
    Type: Application
    Filed: December 14, 2017
    Publication date: April 19, 2018
    Inventors: Yanfeng ZHANG, Hongtao NIE, Minggui XIA, Wenyan LIU, Liang ZHANG
  • METHOD AND DEVICE FOR FISCHER-TROPSCH SYNTHESIS
    Publication number: 20180094196
    Abstract: A method for Fischer-Tropsch synthesis, the method including: 1) gasifying a raw material to obtain a crude syngas including H2, CO and CO2; 2) electrolyzing a saturated NaCl solution using a chloralkali process to obtain a NaOH solution, H2 and H2; 3) removing the CO2 in the crude syngas using the NaOH solution obtained in 2) to obtain a pure syngas; and 4) insufflating the H2 obtained in 2) to the pure syngas to adjust a mole ratio of CO/H2 in the pure syngas, and then introducing the pure syngas for Fischer-Tropsch synthesis reaction. A device for Fischer-Tropsch synthesis includes a gasification device, an electrolyzer, a first gas washing device, and a Fischer-Tropsch synthesis reactor.
    Type: Application
    Filed: December 4, 2017
    Publication date: April 5, 2018
    Inventors: Daxiang WANG, Pingyu Kuai, Meng Li, Yanfeng Zhang
  • CRYSTALLINE FORM OF AHU377, PREPARATION METHOD AND USE THEREOF
    Publication number: 20180086695
    Abstract: The present disclosure relates to a novel crystalline form of a compound of formula (I), preparation method and use thereof. The novel crystalline form in the present disclosure has good stability, low hygroscopicity, and remarkable purification effect in process. The novel crystalline form of the compound of formula (I) provided by the present disclosure can be used for the preparation of the drug for treating heart failure.
    Type: Application
    Filed: March 18, 2016
    Publication date: March 29, 2018
    Applicant: CRYSTAL PHARMATECH CO., LTD
    Inventors: Minhua CHEN, Yanfeng ZHANG, Chaohui YANG, Shu YU, Xiaoyu ZHANG, Liang ZHANG
  • CRYSTALLINE FORM ALPHA OF IPI-145 AND PREPARATION METHOD THEREOF
    Publication number: 20180072733
    Abstract: The present disclosure relates to crystalline Form ? of a compound of formula (I) used for preparing a blood-cancer drug and preparation method thereof. The crystalline Form ? in the present disclosure has better stability, and its solubility and hygroscopicity meet the requirements of medical use. Form ? has simple preparation method and low manufacturing cost, and provides great value to future optimization and development of this drug.
    Type: Application
    Filed: February 1, 2016
    Publication date: March 15, 2018
    Applicant: CRYSTAL PHARMATECH CO., LTD.
    Inventors: Minhua CHEN, Yanfeng ZHANG, Xiaojuan DIAO, Nan XIA, Xiaoyu ZHANG
  • PREPARATION METHOD OF PCI-32765 CRYSTAL FORM A
    Publication number: 20180065958
    Abstract: A preparation method of PCI-32765 crystalline form A, which comprises the following steps: 1) dissolving free base of PCI-32765 in a good solvent; 2) the solution prepared by Step 1) is dropwise added into an anti-solvent, stirred and added seed crystal of PCI-32765 Form A; Or the solution prepared by Step 1) is dropwise added into the suspension containing seed crystal of PCI-32765 Form A; 3) solution obtained by step 2) is continuously stirred and aged until crystal transformation is completed, then the crystal slurry is obtained; 4) crystal slurry in step 3) is filtered, washed, and dried to obtain the powder of PCI-32765 Form A. The preparation method of crystalline Form A provided by the present disclosure is a simple process and can be easily controlled, scaled up stably and conducted reliably. The process has high yield, good impurity removing capacity and is environmentally friendly.
    Type: Application
    Filed: March 18, 2016
    Publication date: March 8, 2018
    Applicant: CRYSTAL PHARMATECH CO., LTD
    Inventors: Minhua CHEN, Yanfeng ZHANG, Liang ZHANG, Shulin JI
  • Power generation system
    Patent number: 9909496
    Abstract: A power generation system, including: a solar energy concentration system, a biomass gasification device, a gas-powered generator, a steam turbine, a steam-powered generator. The solar energy concentration system is connected to a solar energy heat exchange system. The biomass gasification device is connected to the gas-powered generator. The gas outlet of the gas turbine is connected to the gas exhaust heat system. The second steam outlet of the gas exhaust heat system is connected to the second and the third cylinders of the steam turbine. The first steam outlet of the gas exhaust heat system and the steam outlet of the solar energy heat exchange system are connected to a steam mixing regulating system. The mixed steam outlet of the steam mixing regulating system is connected to the first cylinder of the steam turbine.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: March 6, 2018
    Assignee: WUHAN KAIDI ENGINEERING TECHNOLOGY RESEARCH INSTITUTE CO., LTD.
    Inventors: Yilong Chen, Yanfeng Zhang, Hongming Tang, Wenyan Liu
  • CDK INHIBITOR, EUTECTIC CRYSTAL OF MEK INHIBITOR, AND PREPARATION METHOD THEREFOR
    Publication number: 20180057498
    Abstract: The present disclosure relates to novel co-crystals of a CDK inhibitor and an MEK inhibitor and the preparation methods thereof. Specifically, the present disclosure provides hydrates or anhydrates which are named as Form I, Form II and Form III. The novel co-crystals provided in the present disclosure have good stability, low hygroscopicity and high solubility, and have an important value for further optimization and development of the drug.
    Type: Application
    Filed: April 1, 2016
    Publication date: March 1, 2018
    Applicant: CRYSTAL PHARMATECH CO., LTD
    Inventors: Minhua CHEN, Yanfeng ZHANG, Qiyue LIU, Nan XIA, Chaohui YANG, Xiaoyu ZHANG