Abstract: The present invention lies in the technical field of enzymatic (poly)peptide ligation and specifically relates to methods that allow the ligation of (poly)peptides and oligonucleotides. The methods comprise providing at least one cargo molecule modified with a peptide tag and at least one poly(peptide) to be ligated to the cargo molecule, wherein the peptide tag and/or the (poly)peptide comprises a ligation motif for a peptide ligase, preferably sortase and peptidyl asparaginyl ligases (PALs), such as butelase-1, VyPAL2 or OaAEPI b. The invention also relates to the resulting conjugates and the corresponding uses.

Abstract: The invention provides systems and methods for an autonomous vehicle (AV) control system comprising an onboard unit (OBU) and a roadside unit (RSU), which are two components of an Intelligent Road Infrastructure System (IRIS). This integrated vehicle-road system provides sensing, prediction, decision-making, and control instructions for specific vehicles at a microscopic level. Specifically, through the AV control system, an AV can be effectively and efficiently controlled by the AV itself and/or by the RSU. The AV control system provides individual vehicles with detailed time-sensitive control instructions for vehicles to fulfill driving tasks. In addition, the RSU conducts behavior prediction for individual vehicles at a microscopic level from 1 to 10 milliseconds, which is critical for connected and automated vehicle (CAV) operations.

Abstract: A method for atomic layer etching a metal containing layer is provided. At least a region of a surface of the metal containing layer is modified to form a modified metal containing region by exposing a surface of the metal containing layer to a modification gas, wherein adjacent to the modified metal containing region remains an unmodified metal containing region. The modified metal containing region is selectively removed with respect to the unmodified metal containing region by exposing the surface of the metal containing layer to an inert bombardment plasma generated from an inert gas.

Abstract: A combined platform for testing fireproof materials for cables includes a main frame for providing operating space; an air circulation system including a fresh air supply unit for supplying fresh air into the operating space and an exhaust gas treatment unit for treating the gas in the operating space under set conditions; an open flame system for providing an open flame for testing cables; a water circulation system for supplying water at least to the exhaust gas treatment unit and the operating space; and a control system for collecting at least the temperature and gas concentration in the operating space, and performing process control based on the collected results. The actual working conditions of scenarios such as fire-resistant cable tunnels and fire-resistant cable trenches can be simulated, and multiple tests such as combustion performance test and physical and chemical performance test can be carried out under various working conditions.

Abstract: Disclosed is a tumor vaccine based on tumor-derived microparticles (TMPs), and a preparation method and use thereof. The preparation method includes the following steps: 1, subjecting tumor cells to separation to obtain TMPs; 2, mixing the TMPs with 0.03 ?g/?l of a polyethyleneimine solution to allow a reaction for 10 min to 20 min, and washing to obtain PEI-modified TMPs (TMPs-PEI); and 3, mixing the TMP-PEI with 0.1 ?g/?l of a lipopolysaccharide solution to allow cross-linking for 15 min to 1 h to obtain the tumor vaccine based on TMPs (TMP-PEI-LPS). A nanomaterial prepared by conducting surface modification on the TMPs with an immunologic adjuvant can be disguised as a bacterial analog to promote the recognition of tumor antigens in vivo. Moreover, the TMPs can retain their immunostimulatory ability and reduce their toxicity by using a cross-linking agent coupled with the immunologic adjuvant.

Abstract: An iron-core linear motor forcer (100) with integrated aerostatic bearing guidance is disclosed. The motor forcer (100) comprises (i) an iron-core (10) enclosed within an enclosure (13) having an upper surface (11) and a bottom surface (12), wherein the iron-core (10) is mounted with a plurality of coil windings (16), and a plurality of air supply channels (50) are provided substantially in vertical from the upper surface (11) to the bottom surface (12) of the enclosure (13), and each of the air supply channels (50) is terminated at the bottom surface (12) with one or more orifices (32); and (ii) a linear motor stator (20) having a stator surface (22). The iron-core linear motor forcer (100) is frictionless moving on the motor stator (20).

Abstract: Applications of different configurations of novel glucagon peptide 1 with fatty acid modification or nonmodification in the treatment of T2D or the pancreas protection are provided. The dimer of the present disclosure is formed by two identical cysteine-containing GLP-1 monomers through a disulfide bond. The H-like GLP-1 homodimer (disulfide bond is inside chains) showed remarkable increase in hypoglycemic duration without reducing specific activity. The GLP-1 dimer provided has an in-vivo effective duration of up to 19 days, which significantly prolonged compared with that of the positive control drug Liraglutide with 3 days of effective duration, or thereby greatly promoting the technical advancement in long-acting GLP-1 drugs and facilitating their clinical applications and business. Meanwhile the U-like homodimer (disulfide bond is at the C-terminus) does not affect blood glucose, but can obviously protect pancreatic exocrine cells such as acini and ducts, and improve pancreas function.

Abstract: A clock error prediction method includes: obtaining historical satellite clock error data of a preset time period which includes broadcast ephemeris clock error data and precise ephemeris clock error data; obtaining corrected precise ephemeris clock error data based on the broadcast ephemeris clock error data; obtaining a single-day clock speed of each satellite through fitting based on single-day clock error data in the corrected precise ephemeris clock error data of each satellite; obtaining a clock speed time sequence of each satellite based on the single-day clock speed of each satellite; obtaining a clock speed change rate of each satellite through fitting based on the clock speed time sequence of each satellite; and obtaining a predicted clock error of each satellite in a preset future time period based on an initial clock error value, a clock speed, and the clock speed change rate of each satellite.

Abstract: Provided are a series of 5,6-dihydrothieno[3,4-h]quinazoline compounds as represented by formula (P) and pharmaceutically acceptable salts thereof, and the use of the compounds or pharmaceutically acceptable salts thereof in the preparation of solid tumor drugs, such as solid tumor drugs associated with selective PLK1 inhibitors.

Abstract: In a method of manufacturing a semiconductor device, a fin structure having a channel region protruding from an isolation insulating layer disposed over a semiconductor substrate is formed, a cleaning operation is performed, and an epitaxial semiconductor layer is formed over the channel region. The cleaning operation and the forming the epitaxial semiconductor layer are performed in a same chamber without breaking vacuum.

Abstract: Disclosed are a catalyst component and a catalyst for olefin polymerization, and an olefin polymerization method. The catalyst component comprises magnesium, titanium, a halogen and an internal electron donor, wherein the internal electron donor comprises a monocarboxylic acid ester compound and a diether compound, and the molar ratio of the monocarboxylic acid ester compound to the diether compound is (0.0035-0.7):1. By using the catalyst, a polymer having both a high isotactic index and a high melt flow index can be prepared.

Abstract: An analog input device including at least one mounting panel and a matrix of analog push button assemblies mounted thereon. Each analog push button assembly including an analog pressure sensor including a pressure reception arrangement having an optical sensing sub-arrangement configured to measure an amount of light varied according to a pressure sensed at the pressure reception arrangement and an output terminal for outputting an analog signal corresponding to the amount of light measured, and a plunger element configured to exert the pressure on the pressure reception arrangement. The analog input device may include a multiplexer including an input side coupled to the push button assemblies and an output side; an analog-to-digital converter coupled to the output side of the multiplexer; a processor coupled to the analog-to-digital converter and configured to output a data packet; and a communication interface configured to transmit the data packet to a host computing device.

Abstract: This application discloses an image processing method and apparatus, a storage medium, an electronic device, and a product, and relates to the field of computer technology. This application can be applied to the technical fields of artificial intelligence, a map vehicle network, and a blockchain. The method includes acquiring a pre-set image template, the pre-set image template comprising an image pre-synthesis area, and the image pre-synthesis area being used for synthesizing a predetermined type of image content; identifying a target image file; performing synthesis pre-processing on target image content in the target image file to generate an image to be synthesized, the target image content being the predetermined type of image content; and fusing the image to be synthesized to the image pre-synthesis area to generate a target image.

Abstract: ETA (estimated time of arrival) calculation for a mobile machine is disclosed. The ETA of the mobile machine to a destination is calculated by obtaining a current pose of the mobile machine, obtaining a global path from the current pose of the mobile machine to the destination, obtaining a local path, calculating a dynamic ETA for each pair of the consecutive poses in the local path and summing the calculated dynamic ETAs, calculating a baseline ETA for each pair of consecutive poses from a pose in the global path that is closest to the last pose in the local path to the last pose in the global path and summing the calculated baseline ETAs, and obtaining a total ETA to the destination based on the dynamic ETA and the baseline ETA.

Abstract: A method for atomic layer etching a metal containing layer is provided. At least a region of a surface of the metal containing layer is modified to form a modified metal containing region by exposing a surface of the metal containing layer to a modification gas, wherein adjacent to the modified metal containing region remains an unmodified metal containing region. The modified metal containing region is selectively removed with respect to the unmodified metal containing region by exposing the surface of the metal containing layer to an inert bombardment plasma generated from an inert gas.

Abstract: A touch sensing method and a serial manipulator using the same are disclosed. A serial manipulator using the method may detect and localize external torques by obtaining a torque value of each joint of a serial manipulator through a torque sensor at the joint; obtaining a preset joint angle of each joint from the serial manipulator; calculating a Jacobian matrices of the serial manipulator based on the joint angle of the joints; estimating joint torques of the serial manipulator based on the torque value of each joint and the Jacobian matrices; calculating an error between the torque value of each joint and the estimated joint torque corresponding to the joint; and determining a link of the serial manipulator that is connected to the joint with the minimum calculated error as having been touched.

Abstract: A method for controlling a robotic walking assistant that includes a wheeled base having one or more wheels, two handles and a foldable seat that are coupled to the wheeled base, includes: detecting whether two hands of a user have held the two handles of the robotic walking assistant; receiving a command from the user to select an operation mode in response to detection of the two hands holding the two handles; controlling the wheeled base to move in response to a walking assistive mode being selected; providing resistance to at least one of the one or more wheels according to selection of the user, in response to a walking training mode being selected; and locking the one or more wheels in response to a static training mode being selected.

Abstract: A system and method for implementing a centralized innovation framework module are disclosed. A processor is operatively connected to one or more memories via a communication network. The processor creates a centralized web-based collaborative platform hub for collection of innovation ideas data from end users within an operation space and causes the centralized web-based collaborative platform hub to receive innovation ideas data from an end user related to development of an application. The processor also analyzes the received innovation ideas data establishes, based on analyzing, a connection between the centralized web-based collaborative platform hub and a development platform; migrates the received innovation ideas data onto the development platform; and creates a workflow on the development platform for tracking and managing development processes of the application.

Abstract: A solid component for preparing an olefin polymerization catalyst, and a preparation method therefor and an application thereof are provided. The solid component contains: (i) a magnesium compound as represented by the following formula (1), (ii) a Lewis base (LB), and optionally, (iii) metal components other than magnesium. The LB is a compound as shown in general formula (II) or an amide compound as shown in general formula (II?). The solid component has a better particle morphology, and a catalyst prepared by using the solid component as a carrier is less likely to be crushed, and has better stereostructural orientation in olefin polymerization, particularly in propylene polymerization or copolymerization.

Abstract: A spherical carrier for olefin polymerization catalysts has at least one magnesium-containing compound having a structure represented by formula (1). The spherical carrier has a relatively good particle morphology, and substantially no abnormally morphological particles will appear. A method for preparing the spherical carrier can be used to prepare a carrier having a small particle size and greatly expands the particle size range of the preparable carrier. When the catalyst prepared by using the carrier is used for olefin polymerization, polymerization activity is good, substantially no abnormally morphological material is present, and hydrogen response is good.