Patents by Inventor Yann Chong Tan
Yann Chong Tan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240035019Abstract: Disclosed herein are compositions and methods for sequencing, analyzing, and utilizing samples such as single samples. Also disclosed herein are compositions and methods for matching together two or more sequences from a sample. Also disclosed herein are compositions and methods for expressing and screening molecules of interest.Type: ApplicationFiled: June 28, 2018Publication date: February 1, 2024Inventors: William H. Robinson, Yann Chong Tan, Jeremy Sokolove
-
Publication number: 20230287392Abstract: Disclosed herein are compositions and methods for sequencing, analyzing, and utilizing samples such as single samples. Also disclosed herein are compositions and methods for matching together two or more sequences from a sample. Also disclosed herien are compositions and methods for expressing and screening molecules of interest.Type: ApplicationFiled: August 3, 2021Publication date: September 14, 2023Inventors: William H. Robinson, Yann Chong Tan, Jeremy Sokolove
-
Publication number: 20230140035Abstract: Provided herein are antibodies that bind to tumor tissue through a binding interaction with an extracellular RNA-protein complex. Such antibodies are used in methods of inducing an immune response and methods of inhibiting tumor cell growth. Additionally provided are methods of producing such antibodies.Type: ApplicationFiled: September 26, 2022Publication date: May 4, 2023Inventors: Jeff DeFalco, Daniel Eric Emerling, Jessica Finn, Norman Michael Greenberg, Vera Huang, Shaun M. Lippow, Fengling Liu, Amy Manning-Bog, William H. Robinson, Alexander Scholz, Tito Serafini, Nikhil Vad, Wayne Volkmuth, Yann Chong TAN
-
Publication number: 20220389471Abstract: Provided herein are methods and compositions for analyzing nucleic acids associated with single cells using nucleic acid barcodes. According to some embodiments, a method for producing one or more polynucleotides of interest comprises: obtaining a plurality of RNAs associated with one or more samples, wherein the samples are obtained from one or more subjects, each RNA is associated with a single sample, and the RNAs associated with each sample are present in a separate reaction volume; adding an adapter molecule to the RNAs associated with each sample, wherein the adapter molecule is generated using an enzymatic reaction and comprises a universal priming sequence, a barcode sequence, and a binding site; and incorporating the barcode sequence into one or more polynucleotides associated with each sample, thereby producing the one or more polynucleotides of interest.Type: ApplicationFiled: June 17, 2022Publication date: December 8, 2022Applicants: Atreca, Inc., Atreca, Inc.Inventors: Yann Chong TAN, Gary WITHEY
-
Publication number: 20220389472Abstract: Provided herein are methods and compositions for analyzing nucleic acids associated with single cells using nucleic acid barcodes. According to some embodiments, a method for producing one or more polynucleotides of interest comprises: obtaining a plurality of RNAs associated with one or more samples, wherein the samples are obtained from one or more subjects, each RNA is associated with a single sample, and the RNAs associated with each sample are present in a separate reaction volume; adding an adapter molecule to the RNAs associated with each sample, wherein the adapter molecule is generated using an enzymatic reaction and comprises a universal priming sequence, a barcode sequence, and a binding site; and incorporating the barcode sequence into one or more polynucleotides associated with each sample, thereby producing the one or more polynucleotides of interest.Type: ApplicationFiled: June 17, 2022Publication date: December 8, 2022Inventors: Yann Chong TAN, Gary WITHEY
-
Publication number: 20220370570Abstract: Methods for the treatment and prevention of laminopathies and diseases characterised by hyperlipidemia through LING complex inhibition are disclosed. In particular, LING complex disruption by expression of dominant-negative LING complex proteins alleviates pathophysiology in Lmna mutation-associated muscular dystrophy, progeria, and dilated cardiomyopathy. In addition, LING complex disruption by expression of dominant-negative LING complex proteins also alleviates pathophysiology in mouse models of atherosclerosis and familial hypercholesterolemia.Type: ApplicationFiled: July 14, 2020Publication date: November 24, 2022Inventors: Colin Lawson STEWART, Roshni SINGARAJA, Brian BURKE, Yin Loon LEE, Yann Chong TAN
-
Patent number: 11472885Abstract: Provided herein are antibodies that bind to tumor tissue through a binding interaction with an extracellular RNA-protein complex. Such antibodies are used in methods of inducing an immune response and methods of inhibiting tumor cell growth. Additionally provided are methods of producing such antibodies.Type: GrantFiled: February 14, 2020Date of Patent: October 18, 2022Assignee: Atreca, Inc.Inventors: Jeff DeFalco, Daniel Eric Emerling, Jessica Finn, Norman Michael Greenberg, Vera Huang, Shaun M. Lippow, Fengling Liu, Amy Manning-Bog, William H. Robinson, Alexander Scholz, Tito Serafini, Yann Chong Tan, Nikhil Vad, Wayne Volkmuth
-
Publication number: 20220243240Abstract: Provided herein are methods and compositions for analyzing nucleic acids associated with single cells using nucleic acid barcodes. According to some embodiments, a method for producing one or more polynucleotides of interest comprises: obtaining a plurality of RNAs associated with one or more samples, wherein the samples are obtained from one or more subjects, each RNA is associated with a single sample, and the RNAs associated with each sample are present in a separate reaction volume; adding an adapter molecule to the RNAs associated with each sample, wherein the adapter molecule is generated using an enzymatic reaction and comprises a universal priming sequence, a barcode sequence, and a binding site; and incorporating the barcode sequence into one or more polynucleotides associated with each sample, thereby producing the one or more polynucleotides of interest.Type: ApplicationFiled: April 8, 2022Publication date: August 4, 2022Inventors: Yann Chong TAN, Gary WITHEY
-
Patent number: 11098302Abstract: Disclosed herein are compositions and methods for sequencing, analyzing, and utilizing samples such as single samples. Also disclosed herein are compositions and methods for matching together two or more sequences from a sample. Also disclosed herein are compositions and methods for expressing and screening molecules of interest.Type: GrantFiled: April 27, 2012Date of Patent: August 24, 2021Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States Government as Represented by the Department of Veterans AffairInventors: William H. Robinson, Yann Chong Tan, Jeremy Sokolove
-
Publication number: 20200325242Abstract: Provided herein are antibodies that bind to tumor tissue through a binding interaction with an extracellular RNA-protein complex. Such antibodies are used in methods of inducing an immune response and methods of inhibiting tumor cell growth. Additionally provided are methods of producing such antibodies.Type: ApplicationFiled: February 14, 2020Publication date: October 15, 2020Inventors: Jeff DeFalco, Daniel Eric Emerling, Jessica Finn, Norman Michael Greenberg, Vera Huang, Shaun M. Lippow, Fengling Liu, Amy Manning-Bog, William H. Robinson, Alexander Scholz, Tito Serafini, Yann Chong Tan, Nikhil Vad, Wayne Volkmuth
-
Publication number: 20200123582Abstract: Provided herein are methods and compositions for analyzing nucleic acids associated with single cells using nucleic acid barcodes. According to some embodiments, a method for producing one or more polynucleotides of interest comprises: obtaining a plurality of RNAs associated with one or more samples, wherein the samples are obtained from one or more subjects, each RNA is associated with a single sample, and the RNAs associated with each sample are present in a separate reaction volume; adding an adapter molecule to the RNAs associated with each sample, wherein the adapter molecule is generated using an enzymatic reaction and comprises a universal priming sequence, a barcode sequence, and a binding site; and incorporating the barcode sequence into one or more polynucleotides associated with each sample, thereby producing the one or more polynucleotides of interest.Type: ApplicationFiled: May 3, 2019Publication date: April 23, 2020Inventors: YANN CHONG TAN, GARY WITHEY
-
Patent number: 10316345Abstract: Provided herein are methods and compositions for analyzing nucleic acids associated with single cells using nucleic acid barcodes. According to some embodiments, a method for producing one or more polynucleotides of interest comprises: obtaining a plurality of RNAs associated with one or more samples, wherein the samples are obtained from one or more subjects, each RNA is associated with a single sample, and the RNAs associated with each sample are present in a separate reaction volume; adding an adapter molecule to the RNAs associated with each sample, wherein the adapter molecule is generated using an enzymatic reaction and comprises a universal priming sequence, a barcode sequence, and a binding site; and incorporating the barcode sequence into one or more polynucleotides associated with each sample, thereby producing the one or more polynucleotides of interest.Type: GrantFiled: February 8, 2017Date of Patent: June 11, 2019Assignee: ATRECA, INC.Inventors: Yann Chong Tan, Gary Withey
-
Publication number: 20170369921Abstract: Provided herein are methods and compositions for analyzing nucleic acids associated with single cells using nucleic acid barcodes. According to some embodiments, a method for producing one or more polynucleotides of interest comprises: obtaining a plurality of RNAs associated with one or more samples, wherein the samples are obtained from one or more subjects, each RNA is associated with a single sample, and the RNAs associated with each sample are present in a separate reaction volume; adding an adapter molecule to the RNAs associated with each sample, wherein the adapter molecule is generated using an enzymatic reaction and comprises a universal priming sequence, a barcode sequence, and a binding site; and incorporating the barcode sequence into one or more polynucleotides associated with each sample, thereby producing the one or more polynucleotides of interest.Type: ApplicationFiled: February 8, 2017Publication date: December 28, 2017Inventors: Yann Chong Tan, Gary Withey
-
Patent number: 9834766Abstract: The present disclosure provides methods for optimizing barcode design for multiplex DNA sequencing. Also disclosed are DNA barcodes optimized for use with particular sequencing technologies.Type: GrantFiled: September 4, 2012Date of Patent: December 5, 2017Assignee: Atreca, Inc.Inventors: Wayne Volkmuth, Yann Chong Tan
-
Patent number: 9580736Abstract: Provided herein are methods and compositions for analyzing nucleic acids associated with single cells using nucleic acid barcodes. According to some embodiments, a method for producing one or more polynucleotides of interest comprises: obtaining a plurality of RNAs associated with one or more samples, wherein the samples are obtained from one or more subjects, each RNA is associated with a single sample, and the RNAs associated with each sample are present in a separate reaction volume; adding an adapter molecule to the RNAs associated with each sample, wherein the adapter molecule is generated using an enzymatic reaction and comprises a universal priming sequence, a barcode sequence, and a binding site; and incorporating the barcode sequence into one or more polynucleotides associated with each sample, thereby producing the one or more polynucleotides of interest.Type: GrantFiled: December 30, 2014Date of Patent: February 28, 2017Assignee: Atreca, Inc.Inventors: Yann Chong Tan, Gary Withey
-
Publication number: 20150329891Abstract: Provided herein are methods and compositions for analyzing nucleic acids associated with single cells using nucleic acid barcodes. According to some embodiments, a method for producing one or more polynucleotides of interest comprises: obtaining a plurality of RNAs associated with one or more samples, wherein the samples are obtained from one or more subjects, each RNA is associated with a single sample, and the RNAs associated with each sample are present in a separate reaction volume; adding an adapter molecule to the RNAs associated with each sample, wherein the adapter molecule is generated using an enzymatic reaction and comprises a universal priming sequence, a barcode sequence, and a binding site; and incorporating the barcode sequence into one or more polynucleotides associated with each sample, thereby producing the one or more polynucleotides of interest.Type: ApplicationFiled: December 30, 2014Publication date: November 19, 2015Inventors: YANN CHONG TAN, GARY WITHEY
-
Publication number: 20150133317Abstract: Disclosed herein are compositions and methods for sequencing, analyzing, and utilizing samples such as single samples. Also disclosed herein are compositions and methods for matching together two or more sequences from a sample. Also disclosed herein are compositions and methods for expressing and screening molecules of interest.Type: ApplicationFiled: April 27, 2012Publication date: May 14, 2015Applicants: Department of Veterans Affairs, The Board of Trustees of the Leland Stanford Junior UniversityInventors: William H. Robinson, Yann Chong Tan, Jeremy Sokolove
-
Publication number: 20150080266Abstract: The present disclosure provides methods for optimizing barcode design for multiplex DNA sequencing. Also disclosed are DNA barcodes optimized for use with particular sequencing technologies.Type: ApplicationFiled: September 4, 2012Publication date: March 19, 2015Applicant: Atreca, Inc.Inventors: Wayne Volkmuth, Yann Chong Tan