Patents by Inventor Yannis Psarrakis

Yannis Psarrakis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the preparation of a levothyroxine solution
    Patent number: 11938109
    Abstract: Described is a method for the preparation of an oral levothyroxine composition, comprising the steps of combining levothyroxine or a salt thereof, a water-miscible organic solvent or a sugar alcohol and water, adjusting the pH to at least 8 providing a basic aqueous medium, dissolving the levothyroxine in the basic aqueous medium to yield a levothyroxine solution, and lowering the pH of the levothyroxine solution to between 3.5-4.9. also described is an oral levothyroxine composition obtainable by the said method and its use as a medicament.
    Type: Grant
    Filed: July 23, 2021
    Date of Patent: March 26, 2024
    Assignee: EMP LEVO US B.V.
    Inventors: Yannis Psarrakis, Konstantinos Lioumis
  • METHODS FOR THE PREPARATION OF A LEVOTHYROXINE SOLUTION
    Publication number: 20210353577
    Abstract: Described is a method for the preparation of an oral levothyroxine composition, comprising the steps of combining levothyroxine or a salt thereof, a water-miscible organic solvent or a sugar alcohol and water, adjusting the pH to at least 8 providing a basic aqueous medium, dissolving the levothyroxine in the basic aqueous medium to yield a levothyroxine solution, and lowering the pH of the levothyroxine solution to between 3.5-4.9. also described is an oral levothyroxine composition obtainable by the said method and its use as a medicament.
    Type: Application
    Filed: July 23, 2021
    Publication date: November 18, 2021
    Inventors: Yannis PSARRAKIS, Konstantinos LIOUMIS
  • Methods for the preparation of a levothyroxine solution
    Patent number: 11096915
    Abstract: Described is a method for the preparation of an oral levothyroxine composition, comprising the steps of combining levothyroxine or a salt thereof, a water-miscible organic solvent or a sugar alcohol and water, adjusting the pH to at least 8 providing a basic aqueous medium, dissolving the levothyroxine in the basic aqueous medium to yield a levothyroxine solution, and lowering the pH of the levothyroxine solution to between 3.5-4.9. also described is an oral levothyroxine composition obtainable by the said method and its use as a medicament.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: August 24, 2021
    Assignee: EMP Levo US B.V.
    Inventors: Yannis Psarrakis, Konstantinos Lioumis
  • METHODS FOR THE PREPARATION OF A LEVOTHYROXINE SOLUTION
    Publication number: 20190321316
    Abstract: Described is a method for the preparation of an oral levothyroxine composition, comprising the steps of combining levothyroxine or a salt thereof, a water-miscible organic solvent or a sugar alcohol and water, adjusting the pH to at least 8 providing a basic aqueous medium, dissolving the levothyroxine in the basic aqueous medium to yield a levothyroxine solution, and lowering the pH of the levothyroxine solution to between 3.5-4.9. also described is an oral levothyroxine composition obtainable by the said method and its use as a medicament.
    Type: Application
    Filed: July 5, 2017
    Publication date: October 24, 2019
    Inventors: Yannis PSARRAKIS, Kosta LIOUMIS
  • Method for the preparation of a levothyroxine solution
    Patent number: 9050307
    Abstract: Levothyroxine, also known as L-thyroxine, synthetic T4, or 3,5,3?,5?-tetraiodo-L-thyronine, CAS number 51-48-9, is a synthetic form of thyroxine, used as a hormone substitute for patients with thyroid conditions. The invention relates to a method for the preparation of an oral levothyroxine composition. The method according to the invention results in liquid levothyroxine formulations that have improved storage stability compared to known liquid levothyroxine formulations.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: June 9, 2015
    Assignee: EMP Pharma GmbH
    Inventors: Yannis Psarrakis, Konstantinos I. Lioumis
  • METHOD FOR THE PREPARATION OF A LEVOTHYROXINE SOLUTION
    Publication number: 20140073695
    Abstract: Levothyroxine, also known as L-thyroxine, synthetic T4, or 3,5,3?,5?-tetraiodo-L-thyronine, CAS number 51-48-9, is a synthetic form of thyroxine, used as a hormone substitute for patients with thyroid conditions. The invention relates to a method for the preparation of an oral levothyroxine composition. The method according to the invention results in liquid levothyroxine formulations that have improved storage stability compared to known liquid levothyroxine formulations.
    Type: Application
    Filed: March 10, 2011
    Publication date: March 13, 2014
    Applicant: EMP Pharma GmbH
    Inventors: Yannis Psarrakis, Konstantinos I. Lioumis