Abstract: The disclosure is in part directed to crystalline forms of (R)-1?-(3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-3H-spiro[benzofuran-2,4?-piperidin]-3-amine, its salt, and variants thereof.

Abstract: Disclosed are an intermediate drug having synergistic anticancer activity and a polyethylene glycol-coupled synergistic anticancer drug, and a method preparing therefor and use thereof. The intermediate drug has the general structural formula of (I), and the polyethylene glycol-coupled synergistic anticancer drug has the general structural formula of (II). The drugs achieve the combined medication of various anticancer drugs and avoid the toxic reaction caused by the interaction among the drugs or by the pharmacokinetics of the drugs when taking various anticancer drugs, facilitate overcoming the multidrug resistance of cancers, have a synergistic effect, and can be used for preparing anticancer medicaments and for treating cancers.

Abstract: Provided are a PCR primer pair and an application thereof. The PCR primer pair comprises a first primer and a second primer, wherein the first primer comprises a first specific sequence, a first random sequence, and a first universal sequence, the first specific sequence is located at the 3? end of the first primer, the first random sequence is located at the 5? end of the first primer, and the first universal sequence is located between the first specific sequence and the first random sequence; the second primer comprises a second specific sequence, a second random sequence, and a second universal sequence, the second specific sequence is located at the 3? end of the second primer, the second random sequence is located at the 5? end of the second primer, and the second universal sequence is located between the second specific sequence and the second random sequence, wherein the first random sequence and the second random sequence are inversely complementary.

Abstract: Provided are a PCR primer pair and an application thereof.

Abstract: An electronic package can include modulated mesh planes for reducing crosstalk between adjacent signal wires within the electronic package. Modulated mesh planes above and below a wiring plane can include sets of adjacent wires arranged in an orientation parallel to signal wires within the wiring plane, and sets of adjacent wires arranged in an orientation perpendicular to the signal wires. The sets of wires in each of the mesh planes are each electrically interconnected and insulated by a dielectric layer from the signal wires. The electronic package also includes a region of the mesh planes having the adjacent wires that are arranged in an orientation perpendicular to the signal wires separated by a first distance, and another region of the mesh planes having adjacent wires perpendicular to the signal wires separated by a distance greater than the first distance.

Abstract: Provided is a PCR primer pair, comprising: a first primer and a second primer, wherein the first primer comprises a first specific sequence and a first random sequence; the first specific sequence is located on 3? end of the first primer, and the first random sequence is located on 5? end of the first primer; the second primer comprises a second specific sequence and a second random sequence, the second specific sequence is located on 3? end of the second primer, and the second random sequence is located on 5? end of the second primer; moreover, the first specific sequence and the second specific sequence are an upstream primer and a downstream primer directed to a target sequence respectively, and the first random sequence and the second random sequence are inverse complementary.

Abstract: An electronic package can include modulated mesh planes for reducing crosstalk between adjacent signal wires within the electronic package. Modulated mesh planes above and below a wiring plane can include sets of adjacent wires arranged in an orientation parallel to signal wires within the wiring plane, and sets of adjacent wires arranged in an orientation perpendicular to the signal wires. The sets of wires in each of the mesh planes are each electrically interconnected and insulated by a dielectric layer from the signal wires. The electronic package also includes a region of the mesh planes having the adjacent wires that are arranged in an orientation perpendicular to the signal wires separated by a first distance, and another region of the mesh planes having adjacent wires perpendicular to the signal wires separated by a distance greater than the first distance.

Abstract: An electronic package including modulated mesh planes can reduce crosstalk between adjacent signal wires. Modulated mesh planes above and below a wiring plane include sets of adjacent wires arranged parallel to signal wires within the wiring plane, and sets of adjacent wires arranged perpendicular to the signal wires. The wires in each of the mesh planes are electrically interconnected and insulated from the signal wires by a dielectric layer. The electronic package also includes a region of the mesh planes having the adjacent wires that are perpendicular to the signal wires separated by a first distance, and another region of the mesh planes having adjacent wires perpendicular to the signal wires separated by a distance greater than the first distance. A set of rectangular mesh areas of the mesh planes can be populated with supplemental wires and via interconnect structures which can further reduce crosstalk.

Abstract: System and methods for setting pressure limits for an air supply of a fuel cell (“FC”) system are presented. Certain embodiments disclosed herein may allow a FC system to calculate a minimum and a maximum FC stack cathode inlet pressure based on different operating conditions while ensuring that the FC stack receives a desired air flow. Further embodiments disclosed herein may allow a FC system to maintain a cathode inlet air pressure within a range that protects an associated compressor from entering surge and/or overheating conditions.

Abstract: Embodiments are directed to a method of manufacturing the printed circuit board. The PCB is a multi-layer component, including a dielectric material and an intermediate or second layer adjacently positioned with respect to the dielectric material. The intermediate layer or second layer is comprised of a conductor and fiberglass strands, with the fiberglass strands having an associated orientation. When assembled, the fiberglass and the conductor having a matching orientation and separation distance from a source to a destination.

Abstract: The present application relates to a bone conduction speaker and a smart wearable device as well as resonance processing method. The bone conduction speaker comprises a speaker body for generating vibration, a vibration sound transmitting layer in contact with a port of the speaker body for propagating vibration generated by the speaker body, and a vibration damping layer that wraps a region other than a portion of the speaker body that is in contact with the vibration sound transmitting layer. The smart wearable device is provided with the bone conduction speaker and is in direct contact with the user's body; the resonance processing method comprises filtering an audio signal within the preset frequency range or adjusting a gain of an audio signal within the preset frequency range.

Abstract: Embodiments are directed to a printed circuit board and a method of manufacturing the printed circuit board. The PCB is a multi-layer component, including a dielectric material, an intermediate layer positioned adjacent to the dielectric material, and a conductor positioned adjacent to the intermediate layer. The intermediate layer is comprised of fiberglass strands having an associated orientation. When assembled, the fiberglass of the intermediate layer and the conductor having a matching orientation and separation distance from a source to a destination.

Abstract: The present invention provides an image classification method, comprising: an analyzing step of analyzing the quality of any image; and a determining step of determining a quality category to which the any image belongs according to the analyzing result, wherein the quality categories include a first quality category recommended to be saved and a second quality category recommended to be deleted. Correspondingly, the present invention further provides an image classification apparatus. Through the technical scheme of the present invention, images can be classified according to the quality of the images, so that the user experience is improved.

Abstract: Neuropeptide S receptor agonists are provided. The NPS agonists include trimeric, tetrameric, pentameric or hexameric peptidomimetic analogs exhibiting affinity for and activity at the neuropeptide S receptor. The peptidomimetic molecules may be useful in the treatment of disorders, syndromes and conditions mediated by modulation of the neuropeptide S receptor such as substance abuse, narcolepsy, insomnia, obesity, cognitive decline, dementia, Alzheimer's disease, panic disorder, generalized anxiety, PTSD, phobias, schizophrenia and as supportive medication during any kind of cessation program in cognitive behavioral therapy, such as drug addiction, eating disorders and gambling.

Abstract: According to one embodiment, a source code is parsed to identify a first routine to perform a first function and a second routine to perform a second function. A control signaling topology is determined between the first routine and the second routine based on one or more statements associated with the first routine and the second routine defined in the source code. A first logic block is allocated describing a first hardware configuration representing the first function of the first routine. A second logic block is allocated describing a second hardware configuration representing the second function of the second routine. A register-transfer level (RTL) netlist is generated based on the first logic block and the second logic block. The second logic block is to perform the second function dependent upon the first function performed by the first logic block based on the control signaling topology.

Abstract: Provided are an isolated oligonucleotide and a use thereof in nucleic acid sequencing, wherein the isolated oligonucleotide comprises a first strand, wherein the 5?-end nucleotide of the first strand has a phosphate group, and the 3?-end nucleotide of the first strand is a dideoxynucleotide, and a second strand, wherein the 5?-end nucleotide of the second strand does not have a phosphate group, and the 3?-end nucleotide of the second strand is a dideoxynucleotide, wherein the first strand is longer than the second strand in length, and a double-stranded structure is formed between the first strand and the second strand.

Abstract: Many applications in cell biology, genetic engineering, cell-based therapeutics, and drug discovery require precise and safe methods for introducing membrane-impermeable molecules into cells. This can be implemented satisfactorily by microinjection. However, disadvantages of traditional manual microinjection include high degree of operator skill, low throughput and labor-intensiveness. Many studies have focused on developing automated and high-throughput systems for microinjection to address these limitations. However, none have provided sufficient throughput for applications such as ex vivo cell therapy, where manipulation of many cells is helpful.

Abstract: The invention is about methods for preparing functional polypeptide by multi-mode ultrasound enhancement on enzymolysis, and it relates to the field of functional peptide production technologies. The objective of the invention is to improve the degree of hydrolysis of protein, increase the anti-hypertensive activity of protein hydrolysate, shorten the enzymolysis time and reduce the energy consumption. To achieve this, some methods are developed, such as the method for preparing the anti-hypertensive peptide from wheat gluten by sequential ultrasound enhanced enzymatic hydrolysis, preparation of anti-hypertensive peptide from corn gluten by ultrasonic reverberation field, and the technology for preparing functional polypeptide by countercurrent mode dual frequency ultrasound pretreatment of prion protein. The invention of solid-liquid scanning ultrasonic pretreatment of corn gluten meal suspension leads to an improved efficiency of enzymatic hydrolysis.

Abstract: According to one embodiment, a source code is parsed to identify a first routine to perform a first function and a second routine to perform a second function. A control signaling topology is determined between the first routine and the second routine based on one or more statements associated with the first routine and the second routine defined in the source code. A first logic block is allocated describing a first hardware configuration representing the first function of the first routine. A second logic block is allocated describing a second hardware configuration representing the second function of the second routine. A register-transfer level (RTL) netlist is generated based on the first logic block and the second logic block. The second logic block is to perform the second function dependent upon the first function performed by the first logic block based on the control signaling topology.

Abstract: The present invention provides an image classification method, comprising: an analyzing step of analyzing the quality of any image; and a determining step of determining a quality category to which the any image belongs according to the analyzing result, wherein the quality categories include a first quality category recommended to be saved and a second quality category recommended to be deleted. Correspondingly, the present invention further provides an image classification apparatus. Through the technical scheme of the present invention, images can be classified according to the quality of the images, so that the user experience is improved.