Abstract: A mild cleansing composition nearly saturated, saturated, or supersaturated with at least one active ingredient includes one or more surfactants and one or more active ingredients. The mild cleansing composition can be used to clean the skin and improve skin texture (e.g., the degree of radiance and wrinkles) at the same time.

Abstract: A microparticle forming device is used to form microparticles with uniform particle size and proper roundness, and includes a collection pipe, a fluid nozzle, a reactor and a filter. The collection pipe includes a fluid passage, an aqueous-phase fluid inlet, an oil-phase fluid inlet and a mixed fluid outlet, all of which communicate with the fluid passage. The oil-phase fluid inlet is located between the aqueous-phase fluid inlet and the mixed fluid outlet. The fluid nozzle has a plurality of oil-phase fluid drop outlets aligned with the oil-phase fluid inlet of the collection pipe. The reactor has a reaction chamber communicating with the mixed fluid outlet of the collection pipe, a mixing member accommodated in the reaction chamber, and a microparticle collection port communicating communicated with the reaction chamber. Two opposite ends of the filter respectively communicate with the reaction chamber of the reactor.

Abstract: A nozzle for producing microparticles includes a nozzle body having an oscillating device and an amplifying portion connected to the oscillating device and located between first and second ends of the nozzle body. A through-hole extends from the first end through the amplifying portion and the second end. A tube assembly is mounted in the through-hole and includes first and second tubes between which a first fluid passageway is defined. A second fluid passageway is defined in the second tube. Two ends of the first tube respectively form a first filling port and a plurality of first outlet ports both of which intercommunicate with the first fluid passageway. Two ends of the second tube respectively form a second filling port and a second outlet port both of which intercommunicate with the second fluid passageway. A formation space is defined between the second outlet port and the first outlet ports.

Abstract: A microparticle forming device is used to form microparticles with uniform particle size and proper roundness, and includes a collection pipe, a fluid nozzle, a reactor and a filter. The collection pipe includes a fluid passage, an aqueous-phase fluid inlet, an oil-phase fluid inlet and a mixed fluid outlet, all of which are communicated with the fluid passage. The oil-phase fluid inlet is located between the aqueous-phase fluid inlet and the mixed fluid outlet. The fluid nozzle has a plurality of oil-phase fluid drop outlets aligned with the oil-phase fluid inlet of the collection pipe. The reactor has a reaction chamber communicated with the mixed fluid outlet of the collection pipe, a mixing member accommodated in the reaction chamber, and a microparticle collection port communicated with the reaction chamber. Two opposite ends of the filter are respectively communicated with the reaction chamber of the reactor.

Abstract: A microcarrier forming apparatus includes a tank having an inner periphery. A plurality of spoilers is disposed on the inner periphery of the tank. A spray generator includes a spraying end facing an interior of the tank. A stirrer includes a shaft and a fluid driving member. The shaft includes a central axis inclined from a horizontal plane. The fluid driving member is coupled to the shaft and is disposed in the interior of the tank.

Abstract: A water-phase composition for producing microparticles includes a water-phase fluid, an amphiphilic polymer stabilizing agent, a water-phase surfactant, and an organic solvent. The amphiphilic polymer stabilizing agent can be polyvinyl alcohol. The water-phase surfactant can be polysorbate 20, polysorbate 80, poloxamer 188, or sodium dodecyl sulfate. The water-phase surfactant can be ethyl acetate, dichloromethane, chloroform, or dimethyl sulfoxide.

Abstract: A nozzle for producing microparticles includes a nozzle body having a first end and a second end opposite to the first end. The nozzle body further includes a through-hole extending from the first end through the second end. A fluid passageway is defined in the through-hole and forms a filling port in the first end of the nozzle body and a plurality of outlet ports in the second end of the nozzle body. The nozzle body further includes an oscillating device and an amplifying portion. The oscillating device is connected to the amplifying portion. The amplifying portion surrounds the fluid passageway and is located adjacent to the second end of the nozzle body.

Abstract: A method for producing microparticles includes filling a tank with a first fluid. A nozzle including a plurality of first outlet ports facing the tank is provided. A second fluid forms a plurality of liquid films on the first outlet ports. The liquid films on the first outlet ports absorb a vibrational energy to form a plurality of microdroplets that falls into the first fluid. The first fluid envelops outer layers of the microdroplets to form a plurality of semi-products of microparticles. Each semi-product includes an outer layer formed by the first fluid and an inner layer formed by the second fluid. The semi-products in the tank are collected. The outer layers of the semi-products are removed to form a plurality of microparticle products.

Abstract: A nozzle for producing microparticles includes a nozzle body having an oscillating device and an amplifying portion connected to the oscillating device and located between first and second ends of the nozzle body. A through-hole extends from the first end through the amplifying portion and the second end. A tube assembly is mounted in the through-hole and includes first and second tubes between which a first fluid passageway is defined. A second fluid passageway is defined in the second tube. Two ends of the first tube respectively form a first filling port and a plurality of first outlet ports both of which intercommunicate with the first fluid passageway. Two ends of the second tube respectively form a second filling port and a second outlet port both of which intercommunicate with the second fluid passageway. A formation space is defined between the second outlet port and the first outlet ports.

Abstract: A nozzle for producing microparticles includes a nozzle body having a first end and a second end opposite to the first end. The nozzle body further includes a through-hole extending from the first end through the second end. A fluid passageway is defined in the through-hole and forms a filling port in the first end of the nozzle body and a plurality of outlet ports in the second end of the nozzle body. The nozzle body further includes an oscillating device and an amplifying portion. The oscillating device is connected to the amplifying portion. The amplifying portion surrounds the fluid passageway and is located adjacent to the second end of the nozzle body.

Abstract: High drug load pharmaceutical compositions and production methods thereof are provided. The pharmaceutical composition includes at least one viscous active pharmaceutical ingredient or a pharmaceutically acceptable salts thereof. The at least one viscous active pharmaceutical ingredient accounts for at least 60% by weight of the total solid weight of the pharmaceutical composition. The saturated solution of the at least one viscous active pharmaceutical ingredient has a viscosity of at least 20 centipoises at 25° C. Alternatively, the aqueous solution of the at least one viscous active pharmaceutical ingredient with a concentration lower than 55 wt % has at least a viscosity of at least 10 centipoises at 25° C.

Abstract: A method for preparing the liposome suspensions comprising liposomes with small particle size and uniform particle size distribution by performing an injection process in combination with a one-step extrusion, and further the liposome suspensions obtainable by this method as well as drug-encapsulating liposomes as well as a system for preparing the said liposome suspensions are disclosed.

Abstract: Pharmaceutical compositions containing taxanes having about 5 to about 75% phospholipid, about 0.01 to about 50% of a surfactant of an HLB value greater than 10, about 0.01 to about 50% alcohol and about 0.01 to about 40% taxane(s) or a derivative thereof.

Abstract: A process for the large scale production of a liposome suspension, in which three selected lipid compounds in a predetermined ratio are dissolved in an alcohol solvent to form a mixture, which, in turn, is directly admixed with an aqueous ammonium sulfate solution in a predetermined ratio. The resultant mixture is subjected to a pore-extrusion treatment, followed by dialyzing the pore-extruded mixture with a 5% to 15% sucrose aqueous solution, such that a liposome suspension containing liposome particles suspended in the liposome suspension is obtained. The thus obtained liposome suspension can be used to encapsulate a selected drug, in particular doxorubicin.

Abstract: The present application relates to a concentrated emulsion formulation for water-insoluble silatecan comprising silatecan of 0.01-1.0% (W/W), phospholipid of 4.79-75% (W/W); propylene glycol of 24.79˜95% (W/W); optional ethanol of 0.1-40% (W/W); optional surfactant of 0.1-10% (W/W), especially Tween® 80. The present application also relates to a method for manufacturing the concentrated emulsion formulation.