Patents by Inventor Yao-Sung Chang
Yao-Sung Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7344836Abstract: A method and apparatus designed for nucleic acid hybridization employs a hydrogen bond denaturation area with a higher temperature and a lower temperature nucleic acid hybridization area that is immobilized with nucleic acid probes. Nucleic acid-containing samples are introduced into the hydrogen bond denaturation area for heating curled nucleic acids in samples so that they become linear and are guided into the nucleic acid hybridization area. In this area, the nucleic acid hybridization rate can be multiplied by increasing the kinetic energy by the repeated flow of driven fluid. The nucleic acid hybridization apparatus provided by the invention contains a hydrogen bond denaturation area, a nucleic acid hybridization area, a two-way driving apparatus, and a temperature control element.Type: GrantFiled: August 12, 2004Date of Patent: March 18, 2008Assignee: Industrial Technology Research InstituteInventors: Yung-Chiang Chung, Yao-Sung Chang, Ming-Zheng Shiu
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Patent number: 7157269Abstract: The invention discloses an on-spot hydrophilic enhanced slide/microarray. The preparation method relates to a hydrophobic copolymer prepared by blending, grafting or co-polymerization of a hydrophobic material and a compound bearing functional groups such as anhydride, imide, cyclic amide, and cyclic ester, and application of the hydrophobic copolymer onto an organic or inorganic substrate. The resulting slide has the properties of on-spot hydrophilic/hydrophobic dynamic conversion, as well as on-spot hydrophilic enhancement for the preparation of high-density and high-efficiency bio-chip/microarray.Type: GrantFiled: September 26, 2003Date of Patent: January 2, 2007Assignee: Industrial Technology Research InstituteInventors: Bor-Iaun Jan, Jia-Huey Tsao, Chih-Wei Ho, Yu-Ching Liu, Chao-Chi Pan, Zu-Sho Chow, Yao-Sung Chang, Cheng-Tao Wu, Wen-Hsun Kuo
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Patent number: 6960468Abstract: The invention discloses an on-spot hydrophilic enhanced slide/microarray. The preparation method relates to a hydrophobic copolymer prepared by blending, grafting or co-polymerization of a hydrophobic material and a compound bearing functional groups such as anhydride, imide, cyclic amide, and cyclic ester, and application of the hydrophobic copolymer onto an organic or inorganic substrate. The resulting slide has the properties of on-spot hydrophilic/hydrophobic dynamic conversion, as well as on-spot hydrophilic enhancement for the preparation of high-density and high-efficiency bio-chip/microarray.Type: GrantFiled: May 2, 2002Date of Patent: November 1, 2005Assignee: Industrial Technology Research InstituteInventors: Bor-Iuan Jan, Jia-Huey Tsao, Chih-Wei Ho, Yu-Ching Liu, Chao-Chi Pan, Zu-Sho Chow, Yao-Sung Chang, Cheng-Tao Wu, Wen-Hsun Kuo
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Publication number: 20050014185Abstract: A method and apparatus designed for nucleic acid hybridization employs a hydrogen bond denaturation area with a higher temperature and a lower temperature nucleic acid hybridization area that is immobilized with nucleic acid probes. Nucleic acid-containing samples are introduced into the hydrogen bond denaturation area for heating curled nucleic acids in samples so that they become linear and are guided into the nucleic acid hybridization area. In this area, the nucleic acid hybridization rate can be multiplied by increasing the kinetic energy by the repeated flow of driven fluid. The nucleic acid hybridization apparatus provided by the invention contains a hydrogen bond denaturation area, a nucleic acid hybridization area, a two-way driving apparatus, and a temperature control element.Type: ApplicationFiled: August 12, 2004Publication date: January 20, 2005Inventors: Yung-Chiang Chung, Yao-Sung Chang, Ming-Zheng Shiu
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Patent number: 6733894Abstract: The invention features a method for preparing a high-density functional slide by coating a sol-gel containing amine-group bearing silanes and a solution containing polyaldehyde groups onto an organic or inorganic substrate, respectively. The resulting slide is useful in the preparation of highly homogeneous functional-group slides and the high-density and high-efficiency bio-chip/microarray.Type: GrantFiled: September 19, 2002Date of Patent: May 11, 2004Assignee: Industrial Technology Research InstituteInventors: Chih-Wei Ho, Zu-Sho Chow, Bor-Iuan Jan, Jia-Huey Tsao, Chao-Chi Pan, Wen-Hsun Kuo, Yao-Sung Chang, Cheng-Tao Wu, Yu-Ching Liu
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Publication number: 20040062854Abstract: The invention discloses an on-spot hydrophilic enhanced slide/microarray. The preparation method relates to a hydrophobic copolymer prepared by blending, grafting or co-polymerization of a hydrophobic material and a compound bearing functional groups such as anhydride, imide, cyclic amide, and cyclic ester, and application of the hydrophobic copolymer onto an organic or inorganic substrate. The resulting slide has the properties of on-spot hydrophilic/hydrophobic dynamic conversion, as well as on-spot hydrophilic enhancement for the preparation of high-density and high-efficiency bio-chip/microarray.Type: ApplicationFiled: September 26, 2003Publication date: April 1, 2004Inventors: Bor-Iuan Jan, Jia-Huey Tsao, Chih-Wei Ho, Yu-Ching Liu, Chao-Chi Pan, Zu-Sho Chow, Yao-Sung Chang, Cheng-Tao Wu, Wen-Hsun Kuo
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Publication number: 20030198962Abstract: A method and apparatus designed for nucleic acid hybridization employs a hydrogen bond denaturation area with a higher temperature and a lower temperature nucleic acid hybridization area that is immobilized with nucleic acid probes. Nucleic acid-containing samples are introduced into the hydrogen bond denaturation area for heating curled nucleic acids in samples so that they become linear and are guided into the nucleic acid hybridization area. In this area, the nucleic acid hybridization rate can be multiplied by increasing the kinetic energy by the repeated flow of driven fluid. The nucleic acid hybridization apparatus provided by the invention contains a hydrogen bond denaturation area, a nucleic acid hybridization area, a two-way driving apparatus, and a temperature control element.Type: ApplicationFiled: April 18, 2002Publication date: October 23, 2003Inventors: Yung-Chiang Chung, Yao-Sung Chang, Ming-Zheng Shiu
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Publication number: 20030152931Abstract: The present invention relates to a nucleic acid detection device. The present invention especially relates to a nucleic acid detection device utilizing the novel concept of multiple probes to one target. The device comprises a solid support, on which at least one probe set is attached. The probe set comprises multiple types of oligonucleotide probes, wherein each probe has a unique sequence complementary to the different target nucleic acid. The present invention also relates to a method for detecting nucleic acid. The method involves carrying out a hybridization reaction of the previously described device and a sample in order to determine the nucleic acids present in the sample.Type: ApplicationFiled: February 11, 2002Publication date: August 14, 2003Inventors: Chung-Fan Chiou, Chuan-Hsiung Chang, Cheng-Tao Wu, Yao-Sung Chang, Jie-Len Huang, Chao-Chi Pan
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Publication number: 20030152934Abstract: The invention discloses a device for hybridization reaction between a target molecule in a fluid and a probe, which comprises a microfluidic channel comprising a first portion and a second portion following said first portion; wherein said first portion have an irregular cross section and said second portion has a probe, and a fluid driving element connected the ends of said channel with tubes, wherein said fluid element can move said target molecules back-and-forth for repeatedly passing through said second portion.Type: ApplicationFiled: February 11, 2002Publication date: August 14, 2003Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Yao-Sung Chang, Yung-Chiang Chung, Ming-Zheng Shiu
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Patent number: 6605363Abstract: The invention features a method for preparing a high-density functional slide by coating a sol-gel containing amine-group bearing silanes and a solution containing polyaldehyde groups onto an organic or inorganic substrate, respectively. The resulting slide is useful in the preparation of highly homogeneous functional-group slides and the high-density and high-efficiency bio-chip/microarray.Type: GrantFiled: April 18, 2001Date of Patent: August 12, 2003Assignee: Industrial Technology Research InstituteInventors: Chih-Wei Ho, Zu-Sho Chow, Bor-Iuan Jan, Jia-Huey Tsao, Chao-Chi Pan, Wen-Hsun Kuo, Yao-Sung Chang, Cheng-Tao Wu, Yu-Ching Liu
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Publication number: 20030054434Abstract: The invention discloses a method for preparing an active slide, including introducing a monomer containing an aldehyde group, or a mixture of a monomer containing an aldehyde group and an acidic functional group provider into a plasma chamber; and depositing the aldehyde group and acidic functional group onto the surface of an organic or inorganic matrix using plasma deposition to form a slide comprising a layer of polymerized actively functional groups thereon. The aldehyde groups and negatively charged groups are deposited on the surface of the active slide, such that the bio-molecules bound thereto possess the properties of an inducible orientation and thus form a mono-layer.Type: ApplicationFiled: November 6, 2002Publication date: March 20, 2003Inventors: Zu-Sho Chow, Jia-Huey Tsao, Wen-Hsun Kuo, Chih-Wei Ho, Bor-Iuan Jan, Chao-Chi Pan, Yao-Sung Chang, Cheng-Tao Wu, Yu-Ching Liu
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Patent number: 6528291Abstract: A method is provided for preparing an active slide, including introducing a monomer containing an aldehyde group, or a mixture of a monomer containing an aldehyde group and an acidic functional group provider into a plasma chamber; and depositing the aldehyde group and acidic functional group onto the surface of an organic or inorganic matrix using plasma deposition to form a slide comprising a layer of polymerized actively functional groups thereon. The aldehyde groups and negatively charged groups are deposited on the surface of the active slide, such that the bio-molecules bound thereto possess the properties of an inducible orientation and thus form a mono-layer.Type: GrantFiled: September 11, 2000Date of Patent: March 4, 2003Assignee: Industrial Technology Research InstituteInventors: Zu-Sho Chow, Jia-Huey Tsao, Wen-Hsun Kuo, Chih-Wei Ho, Bor-Iuan Jan, Chao-Chi Pan, Yao-Sung Chang, Cheng-Tao Wu, Yu-Ching Liu
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Publication number: 20030017560Abstract: The invention features a method for preparing a high-density functional slide by coating a sol-gel containing amine-group bearing silanes and a solution containing polyaldehyde groups onto an organic or inorganic substrate, respectively. The resulting slide is useful in the preparation of highly homogeneous functional-group slides and the high-density and high-efficiency bio-chip/microarray.Type: ApplicationFiled: September 19, 2002Publication date: January 23, 2003Inventors: Chih-Wei Ho, Zu-Sho Chow, Bor-Iuan Jan, Jia-Huey Tsao, Chao-Chi Pan, Wen-Hsun Kuo, Yao-Sung Chang, Cheng-Tao Wu, Yu-Ching Liu
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Publication number: 20020122875Abstract: The invention discloses an on-spot hydrophilic enhanced slide/microarray. The preparation method relates to a hydrophobic copolymer prepared by blending, grafting or co-polymerization of a hydrophobic material and a compound bearing functional groups such as anhydride, imide, cyclic amide, and cyclic ester, and application of the hydrophobic copolymer onto an organic or inorganic substrate. The resulting slide has the properties of on-spot hydrophilic/hydrophobic dynamic conversion, as well as on-spot hydrophilic enhancement for the preparation of high-density and high-efficiency bio-chip/microarray.Type: ApplicationFiled: May 2, 2002Publication date: September 5, 2002Inventors: Bor-Iuan Jan, Jia-Huey Tsao, Chih-Wei Ho, Yu-Ching Liu, Chao-Chi Pan, Zu-Sho Chow, Yao-Sung Chang, Cheng-Tao Wu, Wen-Hsun Kuo
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Patent number: 6403368Abstract: The invention discloses an on-spot hydrophilic enhanced slide/microarray. The preparation method relates to a hydrophobic copolymer prepared by blending, grafting or co-polymerization of a hydrophobic material and a compound bearing functional groups such as anhydride, imide, cyclic amide, and cyclic ester, and application of the hydrophobic copolymer onto an organic or inorganic substrate. The resulting slide has the properties of on-spot hydrophilic/hydrophobic dynamic conversion, as well as on-spot hydrophilic enhancement for the preparation of high-density and high-efficiency bio-chip/microarray.Type: GrantFiled: October 25, 2000Date of Patent: June 11, 2002Assignee: Industrial Technology Research InstituteInventors: Bor-Iuan Jan, Jia-Huey Tsao, Chih-Wei Ho, Chao-Chi Pan, Zu-Sho Chow, Yao-Sung Chang, Cheng-Tao Wu, Wen-Hsun Kuo
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Publication number: 20020028506Abstract: The invention features a method for preparing a high-density functional slide by coating a sol-gel containing amine-group bearing silanes and a solution containing polyaldehyde groups onto an organic or inorganic substrate, respectively. The resulting slide is useful in the preparation of highly homogeneous functional-group slides and the high-density and high-efficiency bio-chip/microarray.Type: ApplicationFiled: April 18, 2001Publication date: March 7, 2002Inventors: Chih-Wei Ho, Zu-Sho Chow, Bor-Iuan Jan, Jia-Huey Tsao, Chao-Chi Pan, Wen-Hsun Kuo, Yao-Sung Chang, Cheng-Tao Wu, Yu-Ching Liu