Abstract: Semiconductor devices and methods of forming the same include recessing sacrificial layers in a stack of alternating sacrificial layers and channel layers using a first etch to form curved recesses at sidewalls of each sacrificial layer in the stack, with tails of sacrificial material being present at a top and bottom of each curved recess. Dielectric plugs are formed that each partially fill a respective curved recess, leaving exposed at least a portion of each tail of sacrificial material. The tails of sacrificial material are etched back using a second etch to expand the recesses. Inner spacers are formed in the expanded recesses.

Abstract: In one or more embodiments, a metadata-driven user interface is implemented for presenting a set of available services, provided by a plurality of vendors, to a particular service consumer. The system queries metadata associated with of a set of candidate vendors to identify services provided by the candidate vendors that are available to a service consumer. The system generates and customizes the meta-driven interface for the service consumer based on the services available. The system receives user input selecting at least one of the services provided by a vendor. The system then queries configuration information associated with the particular service. The configuration information includes, for example, a workflow associated with the service, and identification of the service consumer's information to be used in execution of the workflow associated with the service. The system obtains the service consumer's information and uses the service consumer's information to cause execution of the workflow.

Abstract: Mapping-aware coding tools for 360 degree videos adapt conventional video coding tools for 360 degree video data using parameters related to a spherical projection of the 360 degree video data. The mapping-aware coding tools perform motion vector mapping techniques, adaptive motion search pattern techniques, adaptive interpolation filter selection techniques, and adaptive block partitioning techniques. Motion vector mapping includes calculating a motion vector for a pixel of a current block by mapping the location of the pixel within a two-dimensional plane (e.g., video frame) onto a sphere and mapping a predicted location of the pixel on the sphere determined based on rotation parameters back onto the plane. Adaptive motion searching, adaptive interpolation filter selection, and adaptive block partitioning operate according to density distortion based on locations along the sphere.

Abstract: A medical system and a medical device. The medical system includes a delivery device and degradable occlude which has a main body, proximal fixing member, distal fixing member, and anchoring portion. The main body has a proximal end connected to the proximal fixing member, and a distal end connected to the distal fixing member. The anchoring portion is defined on the main body. The delivery device includes an external push tube and internal push member. The external push tube is configured to be detachably connected to the proximal fixing member. The internal push member is configured to pass through the external push tube, the proximal fixing member and the main body successively to detachably connect to the distal fixing member. The delivery device is configured to apply an axial pressure to the occluder, to cause the main body to expand from a collapsed configuration to an expanded configuration to drive the anchoring portion to stretch out.

Abstract: The present disclosure relates to the treatment of lung, liver, and/or kidney injury, by administering to a subject in need thereof a therapeutically effective amount of a (very) long acting C-type natriuretic peptide (CNP), CNP derivative, (very) long acting CNP derivative, or (very) long acting CNP receptor (NPRB) agonist. The disclosure also relates to the treatment of non-cardiovascular causes of low blood oxygenation, elevated levels of inflammatory cells in the lung, pulmonary edema, sepsis, bacteremia, fibrosis in general, and/or interstitial lung disease using the same.

Abstract: Various methods, apparatuses/systems, and media for generating a data structure are provided. A database stores a historic version of taxonomy data and a new version of taxonomy data. A processor, operatively connected to the database, accesses the database and analyzes the historic version of taxonomy data and the new version of taxonomy data. The processor determines what changes have been made in connection with a particular reference data based on analyzing the historic version of taxonomy data and the new version of taxonomy data; creates, based on determining, an association between the historic version of taxonomy data and the new version of taxonomy data corresponding to said particular reference data; generates consistent metadata from said association; and generates a data structure that illustrates history of evolution of taxonomy in connection with said particular reference data based on the metadata.

Abstract: A trim assembly for a vehicle seat is provided with a first trim panel adapted to be pivotally connected to a lower region of a rear surface of a backrest that is pivotally adjustable relative to a seat cushion, to cover a gap between the backrest and the seat cushion in an upright position of the backrest. A second trim panel is connected to the first trim panel to cover the gap in a forward position of the backrest relative to the seat cushion.

Abstract: Provided is a humanized anti-IL-4R? single domain antibody. The antibody has complementarity determining regions and humanized and modified framework regions.

Abstract: Disclosed is a system for teaching art courses based on smart cloud technology, including: a teaching management subsystem, designed for providing online teaching function of art courses as well as student user management function for teachers; a smart learning subsystem, designed with online learning function and course management function for each student user; a resource management subsystem, designed to provide art course resources for the teaching management subsystem and the smart learning subsystem, as well as course management function for art course resources; and a background management subsystem, used to provide system management functions for system administrators.

Abstract: Provided are an implantable medical device (100) and a method for manufacturing the same, and a method for manufacturing a stent. The implantable medical device (100) comprises a metal base (110) and a cladding layer (120). The cladding layer (120) is a nickel-free and cobalt-free metal layer which is deposited on the metal base (110) by means of a metal bond. The arrangement of the cladding layer (120) of the implantable medical device (100) on the metal substrate (110) can prevent carcinogenic elements in the metal base (110) such as nickel and cobalt from dissolution. Moreover, the cladding layer (120) is a nickel-free and cobalt-free metal layer, such that the implantable medical device (100) is free from problems of nickel or cobalt dissolution, thereby improving the biological safety of the implantable medical device (100).

Abstract: A chimeric antigen receptor for recognizing an Fc fragment and an application thereof. The chimeric antigen receptor comprises an antigen binding domain, a transmembrane domain, and an intracellular costimulatory signal transduction domain. The antigen binding domain comprises an Fc? receptor extracellular domain. According to the present invention, the Fc? receptor extracellular domain is used as the antigen binding domain of the chimeric antigen receptor, so that the prepared CAR-T cell can recognize the Fc fragment of an antibody, and achieve, when used in combination with a tumor therapeutic antibody containing an IgG1 or IgG3 Fc fragment, an ADCC effect similar to that of natural immune cells such as NK cells; even in the case that antigen loss occurs in tumor cells, the CAR-T can also be used in combination with an antibody for recognizing another target to achieve an efficient killing effect on the tumor cells.

Abstract: The present disclosure provides novel V1a partial agonists for partially activating a V1a receptor. The partial V1a agonist has a therapeutic index of at least 20 (e.g., at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, at least 90, at least 100). Also provided are method of treating liver fibrosis, cirrhosis, portal hypertension, ascites, esophageal varices, fundal varices, bleeding, arterial hypotension, and/or hepatorenal syndrome, including administering to a subject in need thereof a therapeutically effective dose of a composition including the V1a partial agonist(s) of the present disclosure, optionally in combination with a V2 antagonist.

Abstract: The present disclosure relates to methods of treating a subject having abnormal vasculature by administering to the subject a therapeutically effective bolus dose of a composition including a long acting C-type natriuretic peptide (CNP), CNP derivative, long acting CNP derivative, long acting CNP receptor (NPRB) agonist, or any combination thereof. The present disclosure further relates to treating a subject in need of an increase in cytotoxic T cell and/or NK cell activity by administering to the subject a therapeutically effective bolus dose of a composition including a long acting C-type natriuretic peptide (CNP), CNP derivative, long acting CNP derivative, long acting CNP receptor (NPRB) agonist, or any combination thereof.

Abstract: The present disclosure relates to a scFv amino acid sequence capable of recognizing CD19 antigen and a nucleotide sequence encoding the same, and also relates to a chimeric antigen receptor, a nucleic acid encoding the same and a cell expressing the same, and their uses in the manufacture of a medicament for treating tumors. The chimeric antigen receptor of the present disclosure comprises at least one extracellular domain, an optional transmembrane domain and at least one intracellular costimulatory signaling domain, wherein the extracellular domain comprises a CD19 antigen-recognizing and binding domain. The chimeric antigen receptor of the present disclosure has been humanized, resulting in a longer survival period in vivo, and a corresponding extended complete remission period in patients.

Abstract: Disclosed are an IL-5 binding molecule, and a preparation method and use thereof. The binding molecule includes the following complementarity determining regions: an amino acid sequence of CDR1 selected from any one of sequences as set forth in SEQ ID NOs. 43-49; an amino acid sequence of CDR2 selected from any one of sequences as set forth in SEQ ID NOs. 50-56; and an amino acid sequence of CDR3 selected from any one of sequences as set forth in SEQ ID NOs. 57-62. The binding molecule is capable of specifically binding to IL-5, and effectively blocking the cell proliferation induced by IL-5.

Abstract: A method for manufacturing a semiconductor device includes forming a plurality of first semiconductor layers alternately stacked with a plurality of second semiconductor layers on a semiconductor substrate, and laterally recessing the plurality of first semiconductor layers with respect to the plurality of second semiconductor layers to form a plurality of vacant areas on lateral sides of the plurality of first semiconductor layers. In the method, a plurality of first inner spacers are formed on the lateral sides of the plurality of first semiconductor layers in respective ones of the plurality of vacant areas, and a plurality of second inner spacers are formed on sides of the plurality of first inner spacers in the respective ones of the plurality of vacant areas. The method also includes laterally recessing the plurality of second semiconductor layers, and growing a plurality of source/drain regions from the plurality of second semiconductor layers.

Abstract: A standard for near end crosstalk of a category 6A cable, including a registered jack 45 (RJ45), a clamp connected to the RJ45, a first attenuator and a second attenuator. The RJ45 includes a first signal twisted pair to transmit a first source signal and a second source signal, and a second signal twisted pair to transmit a third source signal and a fourth source signal. The clamp includes a first signal pair connector electrically connected to the first signal twisted pair, a second signal pair connector electrically connected to the second signal twisted pair, a first differential amplification circuit and a second differential amplification circuit. The first attenuator is electrically connected to the first signal pair connector. The second attenuator is electrically connected to the second signal pair connector. The second attenuator and the first attenuator are configured to detect the near end crosstalk.

Abstract: A medical diagnosis screens a biomarker for lung cancer detection by utilizing serum metabonomics. The medical diagnosis includes a biomarker for differential diagnosis between patients with lung cancer and healthy people, and between patients with lung cancer and patients with benign pulmonary nodules, and a biomarker for differential diagnosis between patients with lung cancer and healthy people, and between patients with lung cancer and patients with benign pulmonary nodules according to gender differences between a man and a woman. The biomarker is of great significance especially in the differential diagnosis of whether a patient with nodules in the lung has lung cancer.

Abstract: A nanosheet semiconductor device includes channel nanosheets each connected to a source/drain region that has a front surface, a rear surface, and an internal recess between the front surface and the rear surface. The device further includes a source/drain region contact in physical contact with the V shaped internal recess, with the front surface, and with the rear surface. The device may be fabricated by forming the source/drain region, recessing the source/drain region, and by forming a sacrificial source/drain region upon and around the recessed source/drain region. The sacrificial source/drain region may be removed and the source/drain region contact may be formed in place thereof.

Abstract: Mapping-aware coding tools for 360 degree videos adapt conventional video coding tools for 360 degree video data using parameters related to a spherical projection of the 360 degree video data. The mapping-aware coding tools perform motion vector mapping techniques, adaptive motion search pattern techniques, adaptive interpolation filter selection techniques, and adaptive block partitioning techniques. Motion vector mapping includes calculating a motion vector for a pixel of a current block by mapping the location of the pixel within a two-dimensional plane (e.g., video frame) onto a sphere and mapping a predicted location of the pixel on the sphere determined based on rotation parameters back onto the plane. Adaptive motion searching, adaptive interpolation filter selection, and adaptive block partitioning operate according to density distortion based on locations along the sphere.