Patents by Inventor Yasheen Zhou
Yasheen Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240132525Abstract: The present disclosure describes boron containing pyrimidine compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the present disclosure have activity as Janus kinase (JAK) inhibitors and are useful in the in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described are methods of treating inflammation, auto-immune diseases, cancer, and other conditions that are susceptible to the inhibition of a Janus kinase by administering a compound herein described.Type: ApplicationFiled: June 16, 2023Publication date: April 25, 2024Inventors: ALAN LONG, SHON R. PULLEY, KEITH ANDREW NEWTON GRAHAM, CHUNLIANG LIU, YASHEEN ZHOU
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Patent number: 11834466Abstract: A benzoxaborole formulation composition including a benzoxaborole, a non-ionic surfactant, or a non-ionic and ionic surfactant mixture, and a carrier is described herein. At least one of the non-ionic surfactant, the non-ionic and ionic surfactant mixture, and the carrier comprise a Lewis base or a N—H or O—H bond. The carrier is a solid or a liquid. Benzoxaborole compounds and methods of using the compounds and formulations of the compounds are described. For example, a method for reducing, preventing, ameliorating, or inhibiting an infestation by a pathogen by applying a compound or a formulation of a compound, wherein the pathogen is selected from insects, nematodes, bacteria, microbes, fungi, protozoa, viruses, and parasites, or any combinations thereof is described.Type: GrantFiled: November 30, 2018Date of Patent: December 5, 2023Assignee: 5Metis, Inc.Inventors: Marissa Aubrey, Chun Yu Liu, Chunliang Liu, Michael Samuels, Yong-Kang Zhang, Yasheen Zhou
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Patent number: 11827657Abstract: The present invention describes novel boron containing pyrazole compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the invention have activity as Janus kinase (JAK) inhibitors and are useful in the in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described are methods of treating inflammation, auto-immune diseases, cancer, and other conditions that are susceptible to the inhibition of a Janus kinase by administering a compound herein described.Type: GrantFiled: December 13, 2021Date of Patent: November 28, 2023Assignees: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC., BORAH, INC.Inventors: Alan Long, Chun Yu Liu, Chunliang Liu, Yasheen Zhou, Shon R. Pulley, Keith Andrew Newton Graham
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Publication number: 20230148402Abstract: The present invention relates to boron containing compounds of Formula (I) X—Y—Z ??Formula (I) that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating diseases, conditions, or disorders ameliorated by inhibition of PDE4.Type: ApplicationFiled: December 15, 2022Publication date: May 11, 2023Applicant: Pfizer Inc.Inventors: Tsutomu Akama, David Clive Blakemore, Robert Toms Jacobs, Peter Jones, David Christopher Limburg, Martins Sunday Oderinde, Matthew Alexander Perry, Jacob John Plattner, Joseph Walter Strohbach, Rubben Federico Torella, Thean Yeow Yeoh, Yasheen Zhou
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Patent number: 11559538Abstract: The present invention relates to boron containing compounds of Formula (IA): that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating diseases, conditions, or disorders ameliorated by inhibition of PDE4.Type: GrantFiled: October 28, 2020Date of Patent: January 24, 2023Assignee: Pfizer Inc.Inventors: Joseph Walter Strohbach, Tsutomu Akama, David Clive Blakemore, Robert Toms Jacobs, Peter Jones, David Christopher Limburg, Martins Sunday Oderinde, Matthew Alexander Perry, Jacob John Plattner, Rubben Federico Torella, Yasheen Zhou, Thean Yeow Yeoh
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Publication number: 20220273683Abstract: Compounds, pharmaceutical formulations, and methods of treating bacterial infections are disclosed.Type: ApplicationFiled: December 24, 2020Publication date: September 1, 2022Applicant: Bill & Melinda Gates FoundationInventors: Xianfeng LI, Christopher S. LUNDE, Robert T. JACOBS, Yasheen ZHOU
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Publication number: 20220242886Abstract: The present invention describes novel compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the invention have activity as Janus kinase (JAK) inhibitors and are useful in the in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described herein are methods of treating inflammation, auto-immune diseases, cancer, and other conditions susceptible to inhibition of JAK by administering a compound herein described.Type: ApplicationFiled: February 1, 2022Publication date: August 4, 2022Inventors: Yasheen ZHOU, Chunliang LIU, Yong-Kang ZHANG, Marissa AUBREY, Chun Yu LIU
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Publication number: 20220194965Abstract: The present invention describes novel boron containing pyrazole compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the invention have activity as Janus kinase (JAK) inhibitors and are useful in the in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described are methods of treating inflammation, auto-immune diseases, cancer, and other conditions that are susceptible to the inhibition of a Janus kinase by administering a compound herein described.Type: ApplicationFiled: December 13, 2021Publication date: June 23, 2022Inventors: Alan LONG, Chun Yu LIU, Chunliang LIU, Yasheen ZHOU, Shon R. PULLEY, Keith Andrew Newton GRAHAM
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Patent number: 11306108Abstract: The present invention describes novel compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the invention have activity as Janus kinase (JAK) inhibitors and are useful in the in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described herein are methods of treating inflammation, auto-immune diseases, cancer, and other conditions susceptible to inhibition of JAK by administering a compound herein described.Type: GrantFiled: December 23, 2020Date of Patent: April 19, 2022Assignee: Borah, Inc.Inventors: Yasheen Zhou, Chunliang Liu, Yong-Kang Zhang, Marissa Aubrey, Chun Yu Liu
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Publication number: 20210188879Abstract: The present invention describes novel compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the invention have activity as Janus kinase (JAK) inhibitors and are useful in the in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described herein are methods of treating inflammation, auto-immune diseases, cancer, and other conditions susceptible to inhibition of JAK by administering a compound herein described.Type: ApplicationFiled: December 23, 2020Publication date: June 24, 2021Inventors: Yasheen ZHOU, Chunliang LIU, Yong-Kang ZHANG, Marissa AUBREY, Chun Yu LIU
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Publication number: 20210069219Abstract: The present invention relates to boron containing compounds of Formula (I) X—Y—Z?? Formula (I) that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating diseases, conditions, or disorders ameliorated by inhibition of PDE4.Type: ApplicationFiled: October 28, 2020Publication date: March 11, 2021Applicant: Pfizer Inc.Inventors: Joseph Walter Strohbach, Tsutomu Akama, David Clive Blakemore, Robert Toms Jacobs, Peter Jones, David Christopher Limburg, Martins Sunday Oderinde, Matthew Alexander Perry, Jacob John Plattner, Rubben Federico Torella, Yasheen Zhou, Thean Yeow Yeoh
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Patent number: 10874679Abstract: Compounds, pharmaceutical formulations, and methods of treating bacterial infections are disclosed.Type: GrantFiled: April 3, 2020Date of Patent: December 29, 2020Assignee: Bill & Melinda Gates FoundationInventors: Xianfeng Li, Christopher S Lunde, Robert T Jacobs, Yasheen Zhou
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Publication number: 20200385409Abstract: A benzoxaborole formulation composition including a benzoxaborole, a non-ionic surfactant, or a non-ionic and ionic surfactant mixture, and a carrier is described herein. At least one of the non-ionic surfactant, the non-ionic and ionic surfactant mixture, and the carrier comprise a Lewis base or a N—H or O—H bond. The carrier is a solid or a liquid. Benzoxaborole compounds and methods of using the compounds and formulations of the compounds are described. For example, a method for reducing, preventing, ameliorating, or inhibiting an infestation by a pathogen by applying a compound or a formulation of a compound, wherein the pathogen is selected from insects, nematodes, bacteria, microbes, fungi, protozoa, viruses, and parasites, or any combinations thereof is described.Type: ApplicationFiled: November 30, 2018Publication date: December 10, 2020Inventors: Marissa AUBREY, Chun Yu LIU, Chunliang LIU, Michael SAMUELS, Yong-Kang ZHANG, Yasheen ZHOU
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Publication number: 20200230160Abstract: Compounds, pharmaceutical formulations, and methods of treating bacterial infections are disclosed.Type: ApplicationFiled: April 3, 2020Publication date: July 23, 2020Applicant: Bill and Melinda Gates FoundationInventors: Xianfeng LI, Christopher S. LUNDE, Robert T. JACOBS, Yasheen ZHOU
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Publication number: 20200108083Abstract: The present invention relates to boron containing compounds of Formula (I) X—Y—Z?? Formula (I) that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating diseases, conditions, or disorders ameliorated by inhibition of PDE4.Type: ApplicationFiled: October 4, 2019Publication date: April 9, 2020Applicant: Pfizer Inc.Inventors: Joseph Walter Strohbach, Tsutomu Akama, David Clive Blakemore, Robert Toms Jacobs, Peter Jones, David Christopher Limburg, Martins Sunday Oderinde, Matthew Alexander Perry, Jacob John Plattner, Rubben Federico Torella, Yasheen Zhou, Thean Yeow Yeoh
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Patent number: 10611781Abstract: Compounds, pharmaceutical formulations, and methods of treating bacterial infections are disclosed.Type: GrantFiled: February 27, 2017Date of Patent: April 7, 2020Assignee: Bill and Melinda Gates FoundationInventors: Xianfeng Li, Christopher S. Lunde, Robert T. Jacobs, Yasheen Zhou
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Publication number: 20190185493Abstract: Compounds, pharmaceutical formulations, and methods of treating bacterial infections are disclosed.Type: ApplicationFiled: February 27, 2017Publication date: June 20, 2019Inventors: Xianfeng Li, Christopher S. Lunde, Robert T. Jacobs, Yasheen Zhou
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Patent number: 9617285Abstract: Provided are compounds useful for controlling endoparasites both in animals and agriculture. Further provided are methods for controlling endoparasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling endoparasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier.Type: GrantFiled: March 6, 2014Date of Patent: April 11, 2017Assignees: ELI LILLY AND COMPANY, ANACOR PHARMACEUTICALS, INC.Inventors: Tsutomu Akama, Kurt Jarnagin, Jacob J. Plattner, Shon Roland Pulley, William Hunter White, Yong-Kang Zhang, Yasheen Zhou
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Patent number: 9493490Abstract: This invention provides novel compounds of the following formula and pharmaceutical compositions containing such compounds.Type: GrantFiled: July 22, 2014Date of Patent: November 15, 2016Assignee: Anacor Pharmaceuticals, Inc.Inventors: Tsutomu Akama, Kurt Jarnagin, Yong-Kang Zhang, Yasheen Zhou, Jacob J. Plattner, David C. Sullivan
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Patent number: 9346834Abstract: This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.Type: GrantFiled: October 19, 2010Date of Patent: May 24, 2016Assignee: Anacor Pharmaceuticals, Inc.Inventors: Huchen Zhou, Dazhong Ding, Daoan Sun, Yasheen Zhou, Yong-Kang Zhang, Jacob J. Plattner