Patents by Inventor Yashwant D. Karkhanis

Yashwant D. Karkhanis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heat shock process for the isolation of bacterial protein
    Patent number: 4472302
    Abstract: There is disclosed an improved process for the isolation of K-99 outer membrane protein pili from Escherichia coli cells. The improved process involves a heat shock treatment of the E. coli cells in a buffered solution to afford a release of the K-99 pili into solution which on standing results in the aggregation and precipitation of the pili. The thus isolated K-99 protein pili is useful in the preparation of vaccines.
    Type: Grant
    Filed: March 9, 1983
    Date of Patent: September 18, 1984
    Assignee: Merck & Co., Inc.
    Inventor: Yashwant D. Karkhanis
  • Process for solubilization of gonococcal antigen
    Patent number: 4330623
    Abstract: Gonococcal antigens are solubilized by a process involving trypsin-digestion.
    Type: Grant
    Filed: February 19, 1980
    Date of Patent: May 18, 1982
    Assignee: Merck & Co., Inc.
    Inventor: Yashwant D. Karkhanis
  • Antigenic complex from N. gonorrhoeae
    Patent number: 4288557
    Abstract: An antigenic, immunogenic, non-toxic complex is obtained from the cell surface of N. gonorrhoeae.
    Type: Grant
    Filed: March 5, 1980
    Date of Patent: September 8, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Yashwant D. Karkhanis, Dennis J. Carlo
  • E. coli enterotoxin vaccine for veterinary and human use
    Patent number: 4285931
    Abstract: A vaccine against E. coli caused diarrhea is prepared from an isolate of the homogeneous heat-labile enterotoxin of human strain MB3353 of Escherichia coli, ATCC 31361, or of the porcine strain MB3708, ATCC 31362. The toxin, which is a protein, is a low molecular weight species of 10,000-13,000.
    Type: Grant
    Filed: February 15, 1980
    Date of Patent: August 25, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Guadalupe A. Limjuco, Yashwant D. Karkhanis, Dennis J. Carlo
  • Antigenic complex from N. Gonorrhoeae
    Patent number: 4220638
    Abstract: An antigenic, immunogenic, non-toxic complex is obtained from the cell surface of N. gonorrhoeae.
    Type: Grant
    Filed: October 12, 1978
    Date of Patent: September 2, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Yashwant D. Karkhanis, Dennis J. Carlo
  • E. coli enterotoxin vaccine for veterinary and human use
    Patent number: 4220584
    Abstract: A vaccine against E. coli caused diarrhea is prepared from an isolate of the homogeneous heat-labile enterotoxin of human strain MB3353 of Escherichia coli, ATCC 31361, or of the porcine strain MB3708, ATCC 31362. The toxin, which is a protein, is a low molecular weight species of 10,000-13,000.
    Type: Grant
    Filed: January 30, 1978
    Date of Patent: September 2, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Guadalupe A. Limjuco, Yashwant D. Karkhanis, Dennis J. Carlo